| Full name: parathyroid hormone like hormone | Alias Symbol: PTHRP|HHM|PLP|PTHR | ||
| Type: protein-coding gene | Cytoband: 12p11.22 | ||
| Entrez ID: 5744 | HGNC ID: HGNC:9607 | Ensembl Gene: ENSG00000087494 | OMIM ID: 168470 |
| Drug and gene relationship at DGIdb | |||
Expression of PTHLH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTHLH | 5744 | 211756_at | 2.7243 | 0.1672 | |
| GSE20347 | PTHLH | 5744 | 211756_at | 3.0326 | 0.0003 | |
| GSE23400 | PTHLH | 5744 | 211756_at | 2.5026 | 0.0000 | |
| GSE26886 | PTHLH | 5744 | 211756_at | 5.3771 | 0.0000 | |
| GSE29001 | PTHLH | 5744 | 211756_at | 1.9682 | 0.0695 | |
| GSE38129 | PTHLH | 5744 | 211756_at | 3.0844 | 0.0000 | |
| GSE45670 | PTHLH | 5744 | 210355_at | 1.9425 | 0.0122 | |
| GSE53622 | PTHLH | 5744 | 8288 | 2.8281 | 0.0000 | |
| GSE53624 | PTHLH | 5744 | 8288 | 2.6642 | 0.0000 | |
| GSE63941 | PTHLH | 5744 | 211756_at | -1.8980 | 0.4015 | |
| GSE77861 | PTHLH | 5744 | 211756_at | 4.2604 | 0.0020 | |
| GSE97050 | PTHLH | 5744 | A_23_P2271 | 2.9466 | 0.0631 | |
| SRP007169 | PTHLH | 5744 | RNAseq | 4.6320 | 0.0000 | |
| SRP008496 | PTHLH | 5744 | RNAseq | 4.5787 | 0.0000 | |
| SRP064894 | PTHLH | 5744 | RNAseq | 3.4766 | 0.0000 | |
| SRP133303 | PTHLH | 5744 | RNAseq | 4.1208 | 0.0000 | |
| SRP159526 | PTHLH | 5744 | RNAseq | 3.2636 | 0.0006 | |
| SRP219564 | PTHLH | 5744 | RNAseq | 3.5374 | 0.0000 | |
| TCGA | PTHLH | 5744 | RNAseq | 1.3087 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by PTHLH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTHLH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTHLH | 5744 | 11 | 1 | 18 | |
| GSE20123 | PTHLH | 5744 | 11 | 1 | 18 | |
| GSE43470 | PTHLH | 5744 | 10 | 4 | 29 | |
| GSE46452 | PTHLH | 5744 | 10 | 1 | 48 | |
| GSE47630 | PTHLH | 5744 | 13 | 0 | 27 | |
| GSE54993 | PTHLH | 5744 | 0 | 9 | 61 | |
| GSE54994 | PTHLH | 5744 | 12 | 2 | 39 | |
| GSE60625 | PTHLH | 5744 | 0 | 1 | 10 | |
| GSE74703 | PTHLH | 5744 | 9 | 3 | 24 | |
| GSE74704 | PTHLH | 5744 | 6 | 1 | 13 | |
| TCGA | PTHLH | 5744 | 43 | 6 | 47 |
Total number of gains: 125; Total number of losses: 29; Total Number of normals: 334.
Somatic mutations of PTHLH:
Generating mutation plots.
Highly correlated genes for PTHLH:
Showing top 20/1377 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTHLH | CTHRC1 | 0.789341 | 7 | 0 | 7 |
| PTHLH | LAMC2 | 0.786012 | 12 | 0 | 11 |
| PTHLH | CD276 | 0.774067 | 5 | 0 | 5 |
| PTHLH | XPR1 | 0.75753 | 7 | 0 | 7 |
| PTHLH | FSCN1 | 0.756083 | 12 | 0 | 11 |
| PTHLH | IGF2BP2 | 0.753713 | 10 | 0 | 10 |
| PTHLH | MMP1 | 0.750315 | 12 | 0 | 11 |
| PTHLH | COL5A2 | 0.748573 | 11 | 0 | 11 |
| PTHLH | INHBA | 0.743499 | 11 | 0 | 11 |
| PTHLH | TENM2 | 0.743293 | 7 | 0 | 6 |
| PTHLH | ZNF114 | 0.740375 | 4 | 0 | 4 |
| PTHLH | TGFBI | 0.738646 | 12 | 0 | 11 |
| PTHLH | TTYH3 | 0.737381 | 7 | 0 | 7 |
| PTHLH | TNC | 0.73713 | 12 | 0 | 12 |
| PTHLH | LAMA3 | 0.735274 | 11 | 0 | 10 |
| PTHLH | DCBLD1 | 0.732071 | 8 | 0 | 7 |
| PTHLH | SLC2A1 | 0.730857 | 12 | 0 | 12 |
| PTHLH | ZNF469 | 0.729536 | 6 | 0 | 6 |
| PTHLH | ADAMTS12 | 0.726995 | 7 | 0 | 6 |
| PTHLH | MFAP2 | 0.724542 | 11 | 0 | 10 |
For details and further investigation, click here
