| Full name: eukaryotic translation initiation factor 2B subunit gamma | Alias Symbol: EIF2Bgamma|EIF-2B | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 8891 | HGNC ID: HGNC:3259 | Ensembl Gene: ENSG00000070785 | OMIM ID: 606273 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF2B3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2B3 | 8891 | 218488_at | 0.0152 | 0.9771 | |
| GSE20347 | EIF2B3 | 8891 | 218488_at | 0.0466 | 0.8329 | |
| GSE23400 | EIF2B3 | 8891 | 218488_at | -0.0245 | 0.6281 | |
| GSE26886 | EIF2B3 | 8891 | 218488_at | -0.3323 | 0.0746 | |
| GSE29001 | EIF2B3 | 8891 | 218488_at | 0.0590 | 0.8829 | |
| GSE38129 | EIF2B3 | 8891 | 218488_at | -0.0105 | 0.9414 | |
| GSE45670 | EIF2B3 | 8891 | 218488_at | -0.0545 | 0.7902 | |
| GSE53622 | EIF2B3 | 8891 | 22886 | -0.0617 | 0.4632 | |
| GSE53624 | EIF2B3 | 8891 | 22886 | 0.3725 | 0.0000 | |
| GSE63941 | EIF2B3 | 8891 | 218488_at | -0.1073 | 0.8488 | |
| GSE77861 | EIF2B3 | 8891 | 218488_at | -0.0464 | 0.8355 | |
| GSE97050 | EIF2B3 | 8891 | A_23_P115046 | 0.2632 | 0.2794 | |
| SRP007169 | EIF2B3 | 8891 | RNAseq | -0.0008 | 0.9987 | |
| SRP008496 | EIF2B3 | 8891 | RNAseq | -0.1598 | 0.6234 | |
| SRP064894 | EIF2B3 | 8891 | RNAseq | 0.4182 | 0.0446 | |
| SRP133303 | EIF2B3 | 8891 | RNAseq | 0.2950 | 0.0790 | |
| SRP159526 | EIF2B3 | 8891 | RNAseq | 0.0347 | 0.9180 | |
| SRP193095 | EIF2B3 | 8891 | RNAseq | 0.0905 | 0.4607 | |
| SRP219564 | EIF2B3 | 8891 | RNAseq | 0.4612 | 0.4085 | |
| TCGA | EIF2B3 | 8891 | RNAseq | 0.1171 | 0.0527 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF2B3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2B3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2B3 | 8891 | 4 | 3 | 23 | |
| GSE20123 | EIF2B3 | 8891 | 4 | 2 | 24 | |
| GSE43470 | EIF2B3 | 8891 | 7 | 2 | 34 | |
| GSE46452 | EIF2B3 | 8891 | 2 | 1 | 56 | |
| GSE47630 | EIF2B3 | 8891 | 9 | 3 | 28 | |
| GSE54993 | EIF2B3 | 8891 | 0 | 1 | 69 | |
| GSE54994 | EIF2B3 | 8891 | 13 | 2 | 38 | |
| GSE60625 | EIF2B3 | 8891 | 0 | 0 | 11 | |
| GSE74703 | EIF2B3 | 8891 | 6 | 1 | 29 | |
| GSE74704 | EIF2B3 | 8891 | 2 | 0 | 18 | |
| TCGA | EIF2B3 | 8891 | 13 | 16 | 67 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of EIF2B3:
Generating mutation plots.
Highly correlated genes for EIF2B3:
Showing top 20/352 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2B3 | NUP54 | 0.665198 | 3 | 0 | 3 |
| EIF2B3 | TCHP | 0.664599 | 4 | 0 | 4 |
| EIF2B3 | MAD2L2 | 0.647124 | 4 | 0 | 4 |
| EIF2B3 | ZNF318 | 0.638669 | 3 | 0 | 3 |
| EIF2B3 | TMX1 | 0.635872 | 4 | 0 | 3 |
| EIF2B3 | STX10 | 0.635073 | 3 | 0 | 3 |
| EIF2B3 | CHCHD6 | 0.630217 | 3 | 0 | 3 |
| EIF2B3 | MRPL37 | 0.625544 | 8 | 0 | 7 |
| EIF2B3 | RSPRY1 | 0.621552 | 3 | 0 | 3 |
| EIF2B3 | GOLGA5 | 0.618438 | 3 | 0 | 3 |
| EIF2B3 | POLR3K | 0.618108 | 7 | 0 | 6 |
| EIF2B3 | GPANK1 | 0.614571 | 5 | 0 | 4 |
| EIF2B3 | LSM1 | 0.613769 | 4 | 0 | 3 |
| EIF2B3 | PEMT | 0.613387 | 5 | 0 | 4 |
| EIF2B3 | RNF25 | 0.613343 | 4 | 0 | 3 |
| EIF2B3 | IMP4 | 0.61139 | 5 | 0 | 4 |
| EIF2B3 | EEF1E1 | 0.608768 | 7 | 0 | 5 |
| EIF2B3 | POLR2G | 0.608583 | 6 | 0 | 5 |
| EIF2B3 | SDHAF2 | 0.608235 | 3 | 0 | 3 |
| EIF2B3 | PIGV | 0.607974 | 4 | 0 | 3 |
For details and further investigation, click here
