| Full name: elastase, neutrophil expressed | Alias Symbol: NE|HNE|HLE | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 1991 | HGNC ID: HGNC:3309 | Ensembl Gene: ENSG00000197561 | OMIM ID: 130130 |
| Drug and gene relationship at DGIdb | |||
Expression of ELANE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ELANE | 1991 | 206871_at | -0.2436 | 0.4549 | |
| GSE20347 | ELANE | 1991 | 206871_at | -0.0501 | 0.4240 | |
| GSE23400 | ELANE | 1991 | 206871_at | -0.1287 | 0.0000 | |
| GSE26886 | ELANE | 1991 | 206871_at | 0.1913 | 0.0351 | |
| GSE29001 | ELANE | 1991 | 206871_at | -0.0133 | 0.9183 | |
| GSE38129 | ELANE | 1991 | 206871_at | -0.1660 | 0.0110 | |
| GSE45670 | ELANE | 1991 | 206871_at | -0.2644 | 0.0024 | |
| GSE53622 | ELANE | 1991 | 68143 | -1.2873 | 0.0000 | |
| GSE53624 | ELANE | 1991 | 68143 | -0.1791 | 0.1347 | |
| GSE63941 | ELANE | 1991 | 206871_at | -0.0166 | 0.9265 | |
| GSE77861 | ELANE | 1991 | 206871_at | -0.0620 | 0.6344 | |
| TCGA | ELANE | 1991 | RNAseq | -3.3233 | 0.0041 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ELANE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ELANE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ELANE | 1991 | 4 | 6 | 20 | |
| GSE20123 | ELANE | 1991 | 4 | 5 | 21 | |
| GSE43470 | ELANE | 1991 | 1 | 10 | 32 | |
| GSE46452 | ELANE | 1991 | 47 | 1 | 11 | |
| GSE47630 | ELANE | 1991 | 5 | 7 | 28 | |
| GSE54993 | ELANE | 1991 | 13 | 4 | 53 | |
| GSE54994 | ELANE | 1991 | 8 | 15 | 30 | |
| GSE60625 | ELANE | 1991 | 9 | 0 | 2 | |
| GSE74703 | ELANE | 1991 | 1 | 7 | 28 | |
| GSE74704 | ELANE | 1991 | 3 | 3 | 14 | |
| TCGA | ELANE | 1991 | 8 | 25 | 63 |
Total number of gains: 103; Total number of losses: 83; Total Number of normals: 302.
Somatic mutations of ELANE:
Generating mutation plots.
Highly correlated genes for ELANE:
Showing top 20/344 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ELANE | LRRN4CL | 0.666867 | 3 | 0 | 3 |
| ELANE | CCDC151 | 0.662381 | 3 | 0 | 3 |
| ELANE | LENG1 | 0.662359 | 3 | 0 | 3 |
| ELANE | KLK14 | 0.662006 | 3 | 0 | 3 |
| ELANE | ST6GALNAC6 | 0.660038 | 4 | 0 | 4 |
| ELANE | SSC5D | 0.640822 | 4 | 0 | 3 |
| ELANE | ASIC2 | 0.638568 | 3 | 0 | 3 |
| ELANE | DSCAML1 | 0.638177 | 3 | 0 | 3 |
| ELANE | LINC00968 | 0.636703 | 3 | 0 | 3 |
| ELANE | MFSD12 | 0.631687 | 3 | 0 | 3 |
| ELANE | ZNF444 | 0.631246 | 3 | 0 | 3 |
| ELANE | FXYD1 | 0.630498 | 4 | 0 | 3 |
| ELANE | HMCN2 | 0.628981 | 5 | 0 | 4 |
| ELANE | PLAC9 | 0.627726 | 4 | 0 | 4 |
| ELANE | CDH4 | 0.627554 | 5 | 0 | 4 |
| ELANE | EFCAB13 | 0.627349 | 4 | 0 | 3 |
| ELANE | DENND5B | 0.624602 | 3 | 0 | 3 |
| ELANE | SRPK3 | 0.624114 | 4 | 0 | 3 |
| ELANE | PID1 | 0.620824 | 4 | 0 | 4 |
| ELANE | MTAP | 0.620447 | 3 | 0 | 3 |
For details and further investigation, click here
