| Full name: engrailed homeobox 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q14.2 | ||
| Entrez ID: 2019 | HGNC ID: HGNC:3342 | Ensembl Gene: ENSG00000163064 | OMIM ID: 131290 |
| Drug and gene relationship at DGIdb | |||
Expression of EN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EN1 | 2019 | 220559_at | 2.3674 | 0.0354 | |
| GSE20347 | EN1 | 2019 | 220559_at | 1.2019 | 0.0034 | |
| GSE23400 | EN1 | 2019 | 220559_at | 0.9902 | 0.0000 | |
| GSE26886 | EN1 | 2019 | 220559_at | 0.8613 | 0.0047 | |
| GSE29001 | EN1 | 2019 | 220559_at | 1.0880 | 0.0312 | |
| GSE38129 | EN1 | 2019 | 220559_at | 1.4097 | 0.0000 | |
| GSE45670 | EN1 | 2019 | 220559_at | 0.8857 | 0.0092 | |
| GSE53622 | EN1 | 2019 | 63966 | 2.8163 | 0.0000 | |
| GSE53624 | EN1 | 2019 | 63966 | 2.4444 | 0.0000 | |
| GSE63941 | EN1 | 2019 | 220559_at | 1.2527 | 0.1787 | |
| GSE77861 | EN1 | 2019 | 220559_at | 0.5097 | 0.0654 | |
| GSE97050 | EN1 | 2019 | A_23_P56404 | 1.5692 | 0.2066 | |
| SRP133303 | EN1 | 2019 | RNAseq | 5.3252 | 0.0000 | |
| SRP159526 | EN1 | 2019 | RNAseq | 6.8628 | 0.0000 | |
| SRP219564 | EN1 | 2019 | RNAseq | 7.8219 | 0.0000 | |
| TCGA | EN1 | 2019 | RNAseq | 3.7063 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by EN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EN1 | 2019 | 5 | 1 | 24 | |
| GSE20123 | EN1 | 2019 | 5 | 1 | 24 | |
| GSE43470 | EN1 | 2019 | 3 | 1 | 39 | |
| GSE46452 | EN1 | 2019 | 1 | 4 | 54 | |
| GSE47630 | EN1 | 2019 | 6 | 0 | 34 | |
| GSE54993 | EN1 | 2019 | 0 | 6 | 64 | |
| GSE54994 | EN1 | 2019 | 12 | 0 | 41 | |
| GSE60625 | EN1 | 2019 | 0 | 3 | 8 | |
| GSE74703 | EN1 | 2019 | 3 | 1 | 32 | |
| GSE74704 | EN1 | 2019 | 3 | 1 | 16 | |
| TCGA | EN1 | 2019 | 32 | 6 | 58 |
Total number of gains: 70; Total number of losses: 24; Total Number of normals: 394.
Somatic mutations of EN1:
Generating mutation plots.
Highly correlated genes for EN1:
Showing top 20/990 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EN1 | GORAB | 0.714694 | 5 | 0 | 5 |
| EN1 | RASL11B | 0.69112 | 3 | 0 | 3 |
| EN1 | UHRF1 | 0.679693 | 6 | 0 | 6 |
| EN1 | NKX2-2 | 0.67935 | 3 | 0 | 3 |
| EN1 | MSANTD3 | 0.676731 | 5 | 0 | 4 |
| EN1 | FBLIM1 | 0.67642 | 6 | 0 | 5 |
| EN1 | YWHAG | 0.673404 | 4 | 0 | 4 |
| EN1 | ZNF114 | 0.668483 | 4 | 0 | 3 |
| EN1 | ZGRF1 | 0.66727 | 4 | 0 | 4 |
| EN1 | HOXD11 | 0.665446 | 11 | 0 | 10 |
| EN1 | SLC39A3 | 0.665317 | 3 | 0 | 3 |
| EN1 | GPRIN1 | 0.653452 | 6 | 0 | 5 |
| EN1 | POLR1A | 0.650123 | 4 | 0 | 3 |
| EN1 | JADE2 | 0.649038 | 4 | 0 | 3 |
| EN1 | POP1 | 0.646767 | 5 | 0 | 5 |
| EN1 | B3GNT9 | 0.643287 | 5 | 0 | 4 |
| EN1 | GLI2 | 0.640799 | 8 | 0 | 7 |
| EN1 | LRP12 | 0.639763 | 10 | 0 | 10 |
| EN1 | SCYL1 | 0.63923 | 4 | 0 | 3 |
| EN1 | SIX4 | 0.638851 | 5 | 0 | 4 |
For details and further investigation, click here
