| Full name: NK2 homeobox 2 | Alias Symbol: NKX2.2 | ||
| Type: protein-coding gene | Cytoband: 20p11.22 | ||
| Entrez ID: 4821 | HGNC ID: HGNC:7835 | Ensembl Gene: ENSG00000125820 | OMIM ID: 604612 |
| Drug and gene relationship at DGIdb | |||
NKX2-2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of NKX2-2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKX2-2 | 4821 | 206915_at | 0.1720 | 0.3875 | |
| GSE20347 | NKX2-2 | 4821 | 206915_at | 0.1261 | 0.0411 | |
| GSE23400 | NKX2-2 | 4821 | 206915_at | 0.0884 | 0.2744 | |
| GSE26886 | NKX2-2 | 4821 | 206915_at | 0.3088 | 0.0070 | |
| GSE29001 | NKX2-2 | 4821 | 206915_at | 0.3789 | 0.3378 | |
| GSE38129 | NKX2-2 | 4821 | 206915_at | 0.0620 | 0.5231 | |
| GSE45670 | NKX2-2 | 4821 | 206915_at | 0.2118 | 0.4775 | |
| GSE53622 | NKX2-2 | 4821 | 37238 | 0.2248 | 0.3955 | |
| GSE53624 | NKX2-2 | 4821 | 37238 | 0.4765 | 0.0273 | |
| GSE63941 | NKX2-2 | 4821 | 206915_at | 0.2461 | 0.6850 | |
| GSE77861 | NKX2-2 | 4821 | 206915_at | 0.0243 | 0.8474 | |
| TCGA | NKX2-2 | 4821 | RNAseq | -1.3568 | 0.3534 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NKX2-2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NKX2-2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKX2-2 | 4821 | 13 | 1 | 16 | |
| GSE20123 | NKX2-2 | 4821 | 13 | 1 | 16 | |
| GSE43470 | NKX2-2 | 4821 | 11 | 1 | 31 | |
| GSE46452 | NKX2-2 | 4821 | 27 | 1 | 31 | |
| GSE47630 | NKX2-2 | 4821 | 17 | 4 | 19 | |
| GSE54993 | NKX2-2 | 4821 | 0 | 15 | 55 | |
| GSE54994 | NKX2-2 | 4821 | 27 | 2 | 24 | |
| GSE60625 | NKX2-2 | 4821 | 0 | 0 | 11 | |
| GSE74703 | NKX2-2 | 4821 | 8 | 1 | 27 | |
| GSE74704 | NKX2-2 | 4821 | 7 | 1 | 12 |
Total number of gains: 123; Total number of losses: 27; Total Number of normals: 242.
Somatic mutations of NKX2-2:
Generating mutation plots.
Highly correlated genes for NKX2-2:
Showing top 20/108 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKX2-2 | LINC01096 | 0.739534 | 4 | 0 | 4 |
| NKX2-2 | PRSS21 | 0.717289 | 3 | 0 | 3 |
| NKX2-2 | AKT1 | 0.709383 | 3 | 0 | 3 |
| NKX2-2 | FPGS | 0.690316 | 4 | 0 | 3 |
| NKX2-2 | POLE | 0.687402 | 3 | 0 | 3 |
| NKX2-2 | NR2E1 | 0.682866 | 5 | 0 | 4 |
| NKX2-2 | PANK4 | 0.680511 | 3 | 0 | 3 |
| NKX2-2 | EN1 | 0.67935 | 3 | 0 | 3 |
| NKX2-2 | NLGN4X | 0.672622 | 3 | 0 | 3 |
| NKX2-2 | CCDC151 | 0.670832 | 3 | 0 | 3 |
| NKX2-2 | ZNF114 | 0.668326 | 3 | 0 | 3 |
| NKX2-2 | CYP2A13 | 0.667279 | 3 | 0 | 3 |
| NKX2-2 | GIGYF1 | 0.666243 | 3 | 0 | 3 |
| NKX2-2 | SLC10A4 | 0.661969 | 3 | 0 | 3 |
| NKX2-2 | CPXM1 | 0.657939 | 3 | 0 | 3 |
| NKX2-2 | SERPINA3 | 0.657368 | 3 | 0 | 3 |
| NKX2-2 | SZT2 | 0.65344 | 3 | 0 | 3 |
| NKX2-2 | SNRPC | 0.651594 | 3 | 0 | 3 |
| NKX2-2 | PRR12 | 0.6459 | 3 | 0 | 3 |
| NKX2-2 | LRRC41 | 0.643215 | 3 | 0 | 3 |
For details and further investigation, click here
