| Full name: enolase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 2027 | HGNC ID: HGNC:3354 | Ensembl Gene: ENSG00000108515 | OMIM ID: 131370 |
| Drug and gene relationship at DGIdb | |||
ENO3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway |
Expression of ENO3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ENO3 | 2027 | 204483_at | 0.1989 | 0.5661 | |
| GSE20347 | ENO3 | 2027 | 204483_at | 0.2986 | 0.0074 | |
| GSE23400 | ENO3 | 2027 | 204483_at | -0.0346 | 0.5345 | |
| GSE26886 | ENO3 | 2027 | 204483_at | 0.7539 | 0.0000 | |
| GSE29001 | ENO3 | 2027 | 204483_at | 0.2590 | 0.0809 | |
| GSE38129 | ENO3 | 2027 | 204483_at | 0.1867 | 0.1435 | |
| GSE45670 | ENO3 | 2027 | 204483_at | 0.1636 | 0.2874 | |
| GSE53622 | ENO3 | 2027 | 76860 | 0.4140 | 0.0005 | |
| GSE53624 | ENO3 | 2027 | 76860 | 0.5888 | 0.0000 | |
| GSE63941 | ENO3 | 2027 | 204483_at | 0.3326 | 0.5247 | |
| GSE77861 | ENO3 | 2027 | 204483_at | 0.0011 | 0.9937 | |
| GSE97050 | ENO3 | 2027 | A_23_P130149 | -0.9709 | 0.2268 | |
| SRP064894 | ENO3 | 2027 | RNAseq | 1.4042 | 0.0000 | |
| SRP133303 | ENO3 | 2027 | RNAseq | 0.1182 | 0.7012 | |
| SRP159526 | ENO3 | 2027 | RNAseq | 1.1888 | 0.0390 | |
| SRP193095 | ENO3 | 2027 | RNAseq | 0.4127 | 0.0446 | |
| SRP219564 | ENO3 | 2027 | RNAseq | 1.6043 | 0.0415 | |
| TCGA | ENO3 | 2027 | RNAseq | 0.0167 | 0.9350 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ENO3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ENO3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ENO3 | 2027 | 5 | 2 | 23 | |
| GSE20123 | ENO3 | 2027 | 5 | 3 | 22 | |
| GSE43470 | ENO3 | 2027 | 1 | 6 | 36 | |
| GSE46452 | ENO3 | 2027 | 34 | 1 | 24 | |
| GSE47630 | ENO3 | 2027 | 7 | 1 | 32 | |
| GSE54993 | ENO3 | 2027 | 4 | 3 | 63 | |
| GSE54994 | ENO3 | 2027 | 5 | 9 | 39 | |
| GSE60625 | ENO3 | 2027 | 4 | 0 | 7 | |
| GSE74703 | ENO3 | 2027 | 1 | 3 | 32 | |
| GSE74704 | ENO3 | 2027 | 3 | 1 | 16 | |
| TCGA | ENO3 | 2027 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 50; Total Number of normals: 351.
Somatic mutations of ENO3:
Generating mutation plots.
Highly correlated genes for ENO3:
Showing top 20/204 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ENO3 | HGD | 0.638945 | 4 | 0 | 3 |
| ENO3 | MED22 | 0.630349 | 4 | 0 | 4 |
| ENO3 | ANKRD26 | 0.629966 | 4 | 0 | 3 |
| ENO3 | NTNG2 | 0.626287 | 3 | 0 | 3 |
| ENO3 | NCAPH2 | 0.625894 | 3 | 0 | 3 |
| ENO3 | LSG1 | 0.624734 | 3 | 0 | 3 |
| ENO3 | TRIM52-AS1 | 0.615725 | 4 | 0 | 3 |
| ENO3 | EBF4 | 0.61025 | 4 | 0 | 3 |
| ENO3 | SSBP4 | 0.609366 | 3 | 0 | 3 |
| ENO3 | TEAD2 | 0.605555 | 5 | 0 | 5 |
| ENO3 | DPM3 | 0.604024 | 5 | 0 | 3 |
| ENO3 | NFATC1 | 0.603665 | 5 | 0 | 3 |
| ENO3 | CORO6 | 0.603278 | 5 | 0 | 4 |
| ENO3 | NCAPD3 | 0.602729 | 3 | 0 | 3 |
| ENO3 | SLC52A1 | 0.602007 | 6 | 0 | 6 |
| ENO3 | ARL3 | 0.598118 | 5 | 0 | 4 |
| ENO3 | XYLT2 | 0.594966 | 7 | 0 | 5 |
| ENO3 | OBSCN | 0.592896 | 4 | 0 | 3 |
| ENO3 | SCAI | 0.592707 | 4 | 0 | 4 |
| ENO3 | LRRC49 | 0.591874 | 7 | 0 | 5 |
For details and further investigation, click here
