| Full name: EPH receptor A4 | Alias Symbol: Hek8 | ||
| Type: protein-coding gene | Cytoband: 2q36.1 | ||
| Entrez ID: 2043 | HGNC ID: HGNC:3388 | Ensembl Gene: ENSG00000116106 | OMIM ID: 602188 |
| Drug and gene relationship at DGIdb | |||
EPHA4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHA4 | 2043 | 229374_at | -0.0641 | 0.9337 | |
| GSE20347 | EPHA4 | 2043 | 206114_at | 0.0139 | 0.9636 | |
| GSE23400 | EPHA4 | 2043 | 206114_at | -0.0120 | 0.8287 | |
| GSE26886 | EPHA4 | 2043 | 227449_at | -0.2375 | 0.7390 | |
| GSE29001 | EPHA4 | 2043 | 206114_at | 0.2047 | 0.6887 | |
| GSE38129 | EPHA4 | 2043 | 206114_at | 0.1095 | 0.6509 | |
| GSE45670 | EPHA4 | 2043 | 227449_at | 0.8705 | 0.0149 | |
| GSE53622 | EPHA4 | 2043 | 56499 | 0.7986 | 0.0000 | |
| GSE53624 | EPHA4 | 2043 | 56499 | 0.6020 | 0.0000 | |
| GSE63941 | EPHA4 | 2043 | 229374_at | -0.2806 | 0.6841 | |
| GSE77861 | EPHA4 | 2043 | 206114_at | 0.6540 | 0.0353 | |
| GSE97050 | EPHA4 | 2043 | A_23_P108501 | -0.2667 | 0.6563 | |
| SRP007169 | EPHA4 | 2043 | RNAseq | 0.4188 | 0.4667 | |
| SRP008496 | EPHA4 | 2043 | RNAseq | 0.7508 | 0.1090 | |
| SRP064894 | EPHA4 | 2043 | RNAseq | 0.2237 | 0.4954 | |
| SRP133303 | EPHA4 | 2043 | RNAseq | 1.1697 | 0.0034 | |
| SRP159526 | EPHA4 | 2043 | RNAseq | 0.6941 | 0.0031 | |
| SRP193095 | EPHA4 | 2043 | RNAseq | 0.4356 | 0.0736 | |
| SRP219564 | EPHA4 | 2043 | RNAseq | 0.2930 | 0.6676 | |
| TCGA | EPHA4 | 2043 | RNAseq | 0.1253 | 0.4243 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EPHA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHA4 | 2043 | 2 | 13 | 15 | |
| GSE20123 | EPHA4 | 2043 | 2 | 13 | 15 | |
| GSE43470 | EPHA4 | 2043 | 0 | 7 | 36 | |
| GSE46452 | EPHA4 | 2043 | 0 | 5 | 54 | |
| GSE47630 | EPHA4 | 2043 | 4 | 5 | 31 | |
| GSE54993 | EPHA4 | 2043 | 1 | 2 | 67 | |
| GSE54994 | EPHA4 | 2043 | 7 | 10 | 36 | |
| GSE60625 | EPHA4 | 2043 | 0 | 3 | 8 | |
| GSE74703 | EPHA4 | 2043 | 0 | 6 | 30 | |
| GSE74704 | EPHA4 | 2043 | 2 | 7 | 11 | |
| TCGA | EPHA4 | 2043 | 12 | 26 | 58 |
Total number of gains: 30; Total number of losses: 97; Total Number of normals: 361.
Somatic mutations of EPHA4:
Generating mutation plots.
Highly correlated genes for EPHA4:
Showing top 20/103 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHA4 | CNTN1 | 0.701334 | 3 | 0 | 3 |
| EPHA4 | GDAP1 | 0.689131 | 3 | 0 | 3 |
| EPHA4 | FAU | 0.687675 | 3 | 0 | 3 |
| EPHA4 | UBE3C | 0.682038 | 3 | 0 | 3 |
| EPHA4 | ZFR | 0.676654 | 3 | 0 | 3 |
| EPHA4 | PPP2R3C | 0.662178 | 3 | 0 | 3 |
| EPHA4 | UNC45A | 0.662171 | 3 | 0 | 3 |
| EPHA4 | DNAJC19 | 0.661716 | 3 | 0 | 3 |
| EPHA4 | TSPAN3 | 0.660564 | 3 | 0 | 3 |
| EPHA4 | SKA2 | 0.655393 | 3 | 0 | 3 |
| EPHA4 | MIPOL1 | 0.652415 | 3 | 0 | 3 |
| EPHA4 | NDUFA8 | 0.648259 | 3 | 0 | 3 |
| EPHA4 | ITM2C | 0.640056 | 3 | 0 | 3 |
| EPHA4 | KAT5 | 0.639962 | 3 | 0 | 3 |
| EPHA4 | CDC14B | 0.638899 | 3 | 0 | 3 |
| EPHA4 | FOXQ1 | 0.638237 | 3 | 0 | 3 |
| EPHA4 | PAQR3 | 0.637495 | 3 | 0 | 3 |
| EPHA4 | DUSP28 | 0.636893 | 3 | 0 | 3 |
| EPHA4 | CSTF2T | 0.636569 | 3 | 0 | 3 |
| EPHA4 | AGAP1 | 0.636408 | 4 | 0 | 3 |
For details and further investigation, click here
