| Full name: SH2 domain containing 2A | Alias Symbol: TSAd|F2771 | ||
| Type: protein-coding gene | Cytoband: 1q23.1 | ||
| Entrez ID: 9047 | HGNC ID: HGNC:10821 | Ensembl Gene: ENSG00000027869 | OMIM ID: 604514 |
| Drug and gene relationship at DGIdb | |||
SH2D2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04370 | VEGF signaling pathway |
Expression of SH2D2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH2D2A | 9047 | 207351_s_at | 1.1610 | 0.0739 | |
| GSE20347 | SH2D2A | 9047 | 207351_s_at | 0.5405 | 0.0000 | |
| GSE23400 | SH2D2A | 9047 | 207351_s_at | 0.1598 | 0.0040 | |
| GSE26886 | SH2D2A | 9047 | 207351_s_at | 0.3302 | 0.0880 | |
| GSE29001 | SH2D2A | 9047 | 207351_s_at | 0.3088 | 0.0708 | |
| GSE38129 | SH2D2A | 9047 | 207351_s_at | 0.5912 | 0.0000 | |
| GSE45670 | SH2D2A | 9047 | 207351_s_at | 0.7678 | 0.0001 | |
| GSE53622 | SH2D2A | 9047 | 13007 | 1.2867 | 0.0000 | |
| GSE53624 | SH2D2A | 9047 | 13007 | 1.3814 | 0.0000 | |
| GSE63941 | SH2D2A | 9047 | 207351_s_at | 1.0311 | 0.0534 | |
| GSE77861 | SH2D2A | 9047 | 207351_s_at | 0.1555 | 0.6188 | |
| GSE97050 | SH2D2A | 9047 | A_23_P160618 | 0.4790 | 0.1753 | |
| SRP007169 | SH2D2A | 9047 | RNAseq | 0.8726 | 0.2717 | |
| SRP064894 | SH2D2A | 9047 | RNAseq | 1.0626 | 0.0011 | |
| SRP133303 | SH2D2A | 9047 | RNAseq | 0.5084 | 0.0924 | |
| SRP159526 | SH2D2A | 9047 | RNAseq | 1.0002 | 0.0708 | |
| SRP193095 | SH2D2A | 9047 | RNAseq | 1.3480 | 0.0000 | |
| SRP219564 | SH2D2A | 9047 | RNAseq | 1.6390 | 0.0107 | |
| TCGA | SH2D2A | 9047 | RNAseq | 1.0285 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by SH2D2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH2D2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH2D2A | 9047 | 12 | 0 | 18 | |
| GSE20123 | SH2D2A | 9047 | 12 | 0 | 18 | |
| GSE43470 | SH2D2A | 9047 | 7 | 2 | 34 | |
| GSE46452 | SH2D2A | 9047 | 2 | 1 | 56 | |
| GSE47630 | SH2D2A | 9047 | 14 | 0 | 26 | |
| GSE54993 | SH2D2A | 9047 | 0 | 5 | 65 | |
| GSE54994 | SH2D2A | 9047 | 16 | 0 | 37 | |
| GSE60625 | SH2D2A | 9047 | 0 | 0 | 11 | |
| GSE74703 | SH2D2A | 9047 | 7 | 2 | 27 | |
| GSE74704 | SH2D2A | 9047 | 6 | 0 | 14 | |
| TCGA | SH2D2A | 9047 | 38 | 2 | 56 |
Total number of gains: 114; Total number of losses: 12; Total Number of normals: 362.
Somatic mutations of SH2D2A:
Generating mutation plots.
Highly correlated genes for SH2D2A:
Showing top 20/843 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH2D2A | EPHB2 | 0.747233 | 6 | 0 | 6 |
| SH2D2A | BOP1 | 0.745531 | 3 | 0 | 3 |
| SH2D2A | PDE7A | 0.720921 | 5 | 0 | 5 |
| SH2D2A | TMEM138 | 0.704233 | 4 | 0 | 4 |
| SH2D2A | P4HA2 | 0.702567 | 3 | 0 | 3 |
| SH2D2A | TTYH3 | 0.700463 | 7 | 0 | 6 |
| SH2D2A | C4orf46 | 0.696092 | 4 | 0 | 4 |
| SH2D2A | LRR1 | 0.684872 | 5 | 0 | 4 |
| SH2D2A | HTRA4 | 0.681011 | 3 | 0 | 3 |
| SH2D2A | CLPTM1L | 0.679697 | 4 | 0 | 4 |
| SH2D2A | YIF1B | 0.679449 | 4 | 0 | 4 |
| SH2D2A | E2F7 | 0.678849 | 4 | 0 | 4 |
| SH2D2A | CBX3 | 0.678351 | 7 | 0 | 7 |
| SH2D2A | C4orf48 | 0.677247 | 6 | 0 | 5 |
| SH2D2A | MYO10 | 0.676684 | 5 | 0 | 5 |
| SH2D2A | SALL4 | 0.676565 | 7 | 0 | 6 |
| SH2D2A | GPRIN1 | 0.67287 | 6 | 0 | 5 |
| SH2D2A | TACC3 | 0.672662 | 7 | 0 | 6 |
| SH2D2A | C19orf48 | 0.667669 | 3 | 0 | 3 |
| SH2D2A | FCRL2 | 0.666165 | 3 | 0 | 3 |
For details and further investigation, click here
