| Full name: mutY DNA glycosylase | Alias Symbol: MYH | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 4595 | HGNC ID: HGNC:7527 | Ensembl Gene: ENSG00000132781 | OMIM ID: 604933 |
| Drug and gene relationship at DGIdb | |||
Expression of MUTYH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MUTYH | 4595 | 207727_s_at | 0.3942 | 0.2850 | |
| GSE20347 | MUTYH | 4595 | 207727_s_at | 0.4085 | 0.0041 | |
| GSE23400 | MUTYH | 4595 | 207727_s_at | 0.2232 | 0.0000 | |
| GSE26886 | MUTYH | 4595 | 207727_s_at | 1.0643 | 0.0000 | |
| GSE29001 | MUTYH | 4595 | 207727_s_at | 0.3296 | 0.0799 | |
| GSE38129 | MUTYH | 4595 | 207727_s_at | 0.4315 | 0.0001 | |
| GSE45670 | MUTYH | 4595 | 207727_s_at | 0.2887 | 0.0537 | |
| GSE53622 | MUTYH | 4595 | 12443 | 0.5827 | 0.0000 | |
| GSE53624 | MUTYH | 4595 | 12443 | 0.6423 | 0.0000 | |
| GSE63941 | MUTYH | 4595 | 207727_s_at | 1.2871 | 0.0024 | |
| GSE77861 | MUTYH | 4595 | 207727_s_at | 0.2614 | 0.0879 | |
| GSE97050 | MUTYH | 4595 | A_23_P51660 | 0.3367 | 0.2839 | |
| SRP007169 | MUTYH | 4595 | RNAseq | 1.5963 | 0.0188 | |
| SRP064894 | MUTYH | 4595 | RNAseq | 0.4618 | 0.0136 | |
| SRP133303 | MUTYH | 4595 | RNAseq | 0.2558 | 0.2274 | |
| SRP159526 | MUTYH | 4595 | RNAseq | 0.8267 | 0.0421 | |
| SRP193095 | MUTYH | 4595 | RNAseq | 0.3172 | 0.0319 | |
| SRP219564 | MUTYH | 4595 | RNAseq | 0.8133 | 0.0118 | |
| TCGA | MUTYH | 4595 | RNAseq | 0.2388 | 0.0033 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MUTYH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MUTYH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MUTYH | 4595 | 4 | 3 | 23 | |
| GSE20123 | MUTYH | 4595 | 4 | 2 | 24 | |
| GSE43470 | MUTYH | 4595 | 7 | 2 | 34 | |
| GSE46452 | MUTYH | 4595 | 2 | 1 | 56 | |
| GSE47630 | MUTYH | 4595 | 9 | 3 | 28 | |
| GSE54993 | MUTYH | 4595 | 0 | 1 | 69 | |
| GSE54994 | MUTYH | 4595 | 13 | 2 | 38 | |
| GSE60625 | MUTYH | 4595 | 0 | 0 | 11 | |
| GSE74703 | MUTYH | 4595 | 6 | 1 | 29 | |
| GSE74704 | MUTYH | 4595 | 2 | 0 | 18 | |
| TCGA | MUTYH | 4595 | 11 | 16 | 69 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of MUTYH:
Generating mutation plots.
Highly correlated genes for MUTYH:
Showing top 20/932 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MUTYH | SYNGR2 | 0.724138 | 3 | 0 | 3 |
| MUTYH | MCM7 | 0.694396 | 11 | 0 | 11 |
| MUTYH | TMC8 | 0.694003 | 3 | 0 | 3 |
| MUTYH | RAVER1 | 0.68318 | 4 | 0 | 3 |
| MUTYH | RPS19BP1 | 0.680471 | 3 | 0 | 3 |
| MUTYH | KCNQ5 | 0.663456 | 4 | 0 | 3 |
| MUTYH | CCDC77 | 0.658219 | 5 | 0 | 4 |
| MUTYH | RFC4 | 0.657378 | 11 | 0 | 11 |
| MUTYH | ZNF32 | 0.656851 | 3 | 0 | 3 |
| MUTYH | FCHO1 | 0.656832 | 4 | 0 | 4 |
| MUTYH | NOB1 | 0.654591 | 5 | 0 | 4 |
| MUTYH | PPP5C | 0.653973 | 4 | 0 | 3 |
| MUTYH | TXNDC12 | 0.653132 | 7 | 0 | 5 |
| MUTYH | EPHB2 | 0.652151 | 3 | 0 | 3 |
| MUTYH | NEBL-AS1 | 0.651449 | 3 | 0 | 3 |
| MUTYH | KIF2C | 0.65065 | 13 | 0 | 12 |
| MUTYH | STIL | 0.649807 | 12 | 0 | 12 |
| MUTYH | PRTFDC1 | 0.647363 | 4 | 0 | 3 |
| MUTYH | MCM2 | 0.646925 | 12 | 0 | 11 |
| MUTYH | WDR54 | 0.645055 | 6 | 0 | 5 |
For details and further investigation, click here
