RAB8A

 

Full name: RAB8A, member RAS oncogene family Alias Symbol: RAB8
Type: protein-coding gene Cytoband: 19p13.11
Entrez ID: 4218 HGNC ID: HGNC:7007 Ensembl Gene: ENSG00000167461 OMIM ID: 165040
Drug and gene relationship at DGIdb

 

RAB8A involved pathways:

KEGG pathway Description View
hsa04152AMPK signaling pathway

 

Expression of RAB8A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAB8A 4218 208819_at 0.0646 0.9200
GSE20347 RAB8A 4218 208819_at 0.0881 0.4781
GSE23400 RAB8A 4218 208819_at 0.2712 0.0000
GSE26886 RAB8A 4218 208819_at -1.5919 0.0000
GSE29001 RAB8A 4218 208819_at 0.0604 0.8861
GSE38129 RAB8A 4218 208819_at 0.2345 0.0494
GSE45670 RAB8A 4218 208819_at 0.2637 0.0313
GSE53622 RAB8A 4218 93065 0.0442 0.5170
GSE53624 RAB8A 4218 93065 0.2297 0.0000
GSE63941 RAB8A 4218 208819_at 0.6834 0.0630
GSE77861 RAB8A 4218 208819_at 0.4666 0.0142
GSE97050 RAB8A 4218 A_33_P3320127 0.1166 0.6569
SRP007169 RAB8A 4218 RNAseq -0.3985 0.1974
SRP008496 RAB8A 4218 RNAseq -0.4231 0.0085
SRP064894 RAB8A 4218 RNAseq 0.4707 0.0068
SRP133303 RAB8A 4218 RNAseq 0.1929 0.2569
SRP159526 RAB8A 4218 RNAseq 0.0791 0.6323
SRP193095 RAB8A 4218 RNAseq -0.0190 0.8761
SRP219564 RAB8A 4218 RNAseq 0.4084 0.1532
TCGA RAB8A 4218 RNAseq 0.1352 0.0045

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by RAB8A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RAB8A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAB8A 4218 4 3 23
GSE20123 RAB8A 4218 3 2 25
GSE43470 RAB8A 4218 2 6 35
GSE46452 RAB8A 4218 47 1 11
GSE47630 RAB8A 4218 4 8 28
GSE54993 RAB8A 4218 15 4 51
GSE54994 RAB8A 4218 6 14 33
GSE60625 RAB8A 4218 9 0 2
GSE74703 RAB8A 4218 2 4 30
GSE74704 RAB8A 4218 0 1 19
TCGA RAB8A 4218 17 12 67

Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.  

 

Somatic mutations of RAB8A:

 

Generating mutation plots.

 

Highly correlated genes for RAB8A:

 

Showing top 20/337 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAB8ASREBF20.785958303
RAB8ATRIM260.753779303
RAB8ASPNS10.746128303
RAB8ASF10.745525303
RAB8ASTARD50.736778303
RAB8AAKIRIN20.733222303
RAB8ALPCAT40.73253403
RAB8ALGALSL0.723634303
RAB8AFAM192A0.720086404
RAB8ADNAJB60.716888303
RAB8ASERTAD20.709829303
RAB8ADIAPH10.707809403
RAB8APRELID10.701413303
RAB8AGDAP10.699173303
RAB8AMYD880.696121404
RAB8AEMP20.695203404
RAB8APRR30.687948403
RAB8ASRRM10.683751403
RAB8ANAP1L40.683596403
RAB8APSMC10.680697303

For details and further investigation, click here