| Full name: leucine rich repeat containing 23 | Alias Symbol: B7|LRPB7 | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 10233 | HGNC ID: HGNC:19138 | Ensembl Gene: ENSG00000010626 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LRRC23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC23 | 10233 | 206076_at | 0.1604 | 0.7866 | |
| GSE20347 | LRRC23 | 10233 | 206076_at | 0.1919 | 0.2265 | |
| GSE23400 | LRRC23 | 10233 | 206076_at | -0.0071 | 0.8859 | |
| GSE26886 | LRRC23 | 10233 | 206076_at | 1.1708 | 0.0000 | |
| GSE29001 | LRRC23 | 10233 | 206076_at | 0.0293 | 0.8592 | |
| GSE38129 | LRRC23 | 10233 | 206076_at | 0.1545 | 0.2892 | |
| GSE45670 | LRRC23 | 10233 | 206076_at | 0.2751 | 0.2789 | |
| GSE53622 | LRRC23 | 10233 | 27364 | 0.7077 | 0.0000 | |
| GSE53624 | LRRC23 | 10233 | 27364 | 0.6349 | 0.0000 | |
| GSE63941 | LRRC23 | 10233 | 206076_at | 0.4834 | 0.3936 | |
| GSE77861 | LRRC23 | 10233 | 206076_at | 0.5444 | 0.0259 | |
| GSE97050 | LRRC23 | 10233 | A_23_P36689 | -0.1537 | 0.6467 | |
| SRP007169 | LRRC23 | 10233 | RNAseq | 1.4336 | 0.0371 | |
| SRP008496 | LRRC23 | 10233 | RNAseq | 1.1191 | 0.0160 | |
| SRP064894 | LRRC23 | 10233 | RNAseq | 0.4048 | 0.2281 | |
| SRP133303 | LRRC23 | 10233 | RNAseq | 0.7371 | 0.0060 | |
| SRP159526 | LRRC23 | 10233 | RNAseq | 0.9728 | 0.0017 | |
| SRP193095 | LRRC23 | 10233 | RNAseq | 0.5822 | 0.0002 | |
| SRP219564 | LRRC23 | 10233 | RNAseq | 0.5946 | 0.2605 | |
| TCGA | LRRC23 | 10233 | RNAseq | 0.1399 | 0.1282 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LRRC23 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC23 | 10233 | 9 | 3 | 18 | |
| GSE20123 | LRRC23 | 10233 | 9 | 3 | 18 | |
| GSE43470 | LRRC23 | 10233 | 8 | 3 | 32 | |
| GSE46452 | LRRC23 | 10233 | 10 | 1 | 48 | |
| GSE47630 | LRRC23 | 10233 | 12 | 2 | 26 | |
| GSE54993 | LRRC23 | 10233 | 1 | 10 | 59 | |
| GSE54994 | LRRC23 | 10233 | 10 | 2 | 41 | |
| GSE60625 | LRRC23 | 10233 | 0 | 1 | 10 | |
| GSE74703 | LRRC23 | 10233 | 7 | 2 | 27 | |
| GSE74704 | LRRC23 | 10233 | 5 | 3 | 12 | |
| TCGA | LRRC23 | 10233 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.
Somatic mutations of LRRC23:
Generating mutation plots.
Highly correlated genes for LRRC23:
Showing top 20/1108 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC23 | TMTC1 | 0.821405 | 4 | 0 | 4 |
| LRRC23 | GLI3 | 0.799347 | 3 | 0 | 3 |
| LRRC23 | RAD23A | 0.756764 | 4 | 0 | 4 |
| LRRC23 | WIZ | 0.748671 | 4 | 0 | 4 |
| LRRC23 | MAP2K5 | 0.748299 | 4 | 0 | 3 |
| LRRC23 | FAM167B | 0.746573 | 3 | 0 | 3 |
| LRRC23 | DSCC1 | 0.742044 | 4 | 0 | 4 |
| LRRC23 | TAF10 | 0.738924 | 3 | 0 | 3 |
| LRRC23 | FHOD3 | 0.737258 | 3 | 0 | 3 |
| LRRC23 | PSMC5 | 0.735444 | 3 | 0 | 3 |
| LRRC23 | TCF12 | 0.734062 | 3 | 0 | 3 |
| LRRC23 | NF1 | 0.733208 | 3 | 0 | 3 |
| LRRC23 | MLLT1 | 0.727131 | 3 | 0 | 3 |
| LRRC23 | ARPP19 | 0.726795 | 3 | 0 | 3 |
| LRRC23 | ZCCHC3 | 0.71806 | 5 | 0 | 4 |
| LRRC23 | KHSRP | 0.717273 | 4 | 0 | 4 |
| LRRC23 | RNF121 | 0.715208 | 3 | 0 | 3 |
| LRRC23 | RHOBTB3 | 0.71353 | 3 | 0 | 3 |
| LRRC23 | ALG10B | 0.71266 | 3 | 0 | 3 |
| LRRC23 | U2SURP | 0.712317 | 4 | 0 | 4 |
For details and further investigation, click here
