| Full name: NLR family pyrin domain containing 7 | Alias Symbol: PYPAF3|NOD12|PAN7|CLR19.4 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 199713 | HGNC ID: HGNC:22947 | Ensembl Gene: ENSG00000167634 | OMIM ID: 609661 |
Screen Evidence:
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Expression of NLRP7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRP7 | 199713 | 237461_at | 0.3516 | 0.6108 | |
| GSE26886 | NLRP7 | 199713 | 237461_at | 0.5148 | 0.0277 | |
| GSE45670 | NLRP7 | 199713 | 237461_at | 0.4487 | 0.0771 | |
| GSE53622 | NLRP7 | 199713 | 125398 | 1.2794 | 0.0000 | |
| GSE53624 | NLRP7 | 199713 | 125398 | 1.7021 | 0.0000 | |
| GSE63941 | NLRP7 | 199713 | 237461_at | 0.1653 | 0.6203 | |
| GSE77861 | NLRP7 | 199713 | 237461_at | 0.2047 | 0.3339 | |
| GSE97050 | NLRP7 | 199713 | A_23_P16384 | 0.1492 | 0.4748 | |
| TCGA | NLRP7 | 199713 | RNAseq | 0.4744 | 0.4119 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NLRP7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRP7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRP7 | 199713 | 3 | 4 | 23 | |
| GSE20123 | NLRP7 | 199713 | 3 | 3 | 24 | |
| GSE43470 | NLRP7 | 199713 | 3 | 11 | 29 | |
| GSE46452 | NLRP7 | 199713 | 45 | 1 | 13 | |
| GSE47630 | NLRP7 | 199713 | 8 | 6 | 26 | |
| GSE54993 | NLRP7 | 199713 | 17 | 4 | 49 | |
| GSE54994 | NLRP7 | 199713 | 4 | 13 | 36 | |
| GSE60625 | NLRP7 | 199713 | 9 | 0 | 2 | |
| GSE74703 | NLRP7 | 199713 | 3 | 7 | 26 | |
| GSE74704 | NLRP7 | 199713 | 3 | 1 | 16 | |
| TCGA | NLRP7 | 199713 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of NLRP7:
Generating mutation plots.
Highly correlated genes for NLRP7:
Showing top 20/137 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRP7 | LINC00626 | 0.706961 | 3 | 0 | 3 |
| NLRP7 | ICAM2 | 0.684333 | 3 | 0 | 3 |
| NLRP7 | TNFRSF1A | 0.682949 | 3 | 0 | 3 |
| NLRP7 | TMEM52B | 0.667498 | 4 | 0 | 3 |
| NLRP7 | HMGA2 | 0.642955 | 3 | 0 | 3 |
| NLRP7 | WBP11 | 0.623508 | 5 | 0 | 4 |
| NLRP7 | DRAM1 | 0.622122 | 4 | 0 | 4 |
| NLRP7 | SH2D2A | 0.619663 | 5 | 0 | 4 |
| NLRP7 | M6PR | 0.612371 | 3 | 0 | 3 |
| NLRP7 | RCN3 | 0.610307 | 4 | 0 | 4 |
| NLRP7 | GAPDH | 0.609774 | 4 | 0 | 3 |
| NLRP7 | SYNDIG1 | 0.60647 | 5 | 0 | 3 |
| NLRP7 | PDCD1LG2 | 0.6004 | 4 | 0 | 3 |
| NLRP7 | ZNF598 | 0.597242 | 3 | 0 | 3 |
| NLRP7 | AEBP2 | 0.587064 | 4 | 0 | 3 |
| NLRP7 | PRR16 | 0.58383 | 4 | 0 | 3 |
| NLRP7 | SH2B3 | 0.583558 | 5 | 0 | 3 |
| NLRP7 | STRAP | 0.581459 | 5 | 0 | 3 |
| NLRP7 | CHIT1 | 0.580615 | 3 | 0 | 3 |
| NLRP7 | MFAP2 | 0.575775 | 6 | 0 | 6 |
For details and further investigation, click here
