ERCC3

 

Full name: ERCC excision repair 3, TFIIH core complex helicase subunit Alias Symbol: XPB|BTF2|RAD25|TFIIH|GTF2H
Type: protein-coding gene Cytoband: 2q14.3
Entrez ID: 2071 HGNC ID: HGNC:3435 Ensembl Gene: ENSG00000163161 OMIM ID: 133510
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ERCC3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ERCC3 2071 202176_at 0.4595 0.1116
GSE20347 ERCC3 2071 202176_at 0.5206 0.0012
GSE23400 ERCC3 2071 202176_at 0.5252 0.0000
GSE26886 ERCC3 2071 202176_at 0.1735 0.5430
GSE29001 ERCC3 2071 202176_at 0.6682 0.0356
GSE38129 ERCC3 2071 202176_at 0.5783 0.0000
GSE45670 ERCC3 2071 202176_at 0.2974 0.0474
GSE53622 ERCC3 2071 43018 0.4167 0.0000
GSE53624 ERCC3 2071 43018 0.4845 0.0000
GSE63941 ERCC3 2071 202176_at 0.0092 0.9838
GSE77861 ERCC3 2071 202176_at 1.1339 0.0003
GSE97050 ERCC3 2071 A_23_P5325 0.1886 0.3552
SRP007169 ERCC3 2071 RNAseq 0.6280 0.0593
SRP008496 ERCC3 2071 RNAseq 0.9111 0.0000
SRP064894 ERCC3 2071 RNAseq 0.3399 0.0055
SRP133303 ERCC3 2071 RNAseq 0.2891 0.0422
SRP159526 ERCC3 2071 RNAseq 0.5510 0.0096
SRP193095 ERCC3 2071 RNAseq 0.4686 0.0000
SRP219564 ERCC3 2071 RNAseq 0.1111 0.6120
TCGA ERCC3 2071 RNAseq 0.0761 0.1274

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ERCC3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ERCC3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ERCC3 2071 5 3 22
GSE20123 ERCC3 2071 6 3 21
GSE43470 ERCC3 2071 2 1 40
GSE46452 ERCC3 2071 1 3 55
GSE47630 ERCC3 2071 6 0 34
GSE54993 ERCC3 2071 0 6 64
GSE54994 ERCC3 2071 11 0 42
GSE60625 ERCC3 2071 0 3 8
GSE74703 ERCC3 2071 2 1 33
GSE74704 ERCC3 2071 3 1 16
TCGA ERCC3 2071 22 8 66

Total number of gains: 58; Total number of losses: 29; Total Number of normals: 401.  

 

Somatic mutations of ERCC3:

 

Generating mutation plots.

 

Highly correlated genes for ERCC3:

 

Showing top 20/1823 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ERCC3CDCA20.763486404
ERCC3BOLA30.738688606
ERCC3POLR2D0.73847412012
ERCC3HNRNPC0.729868908
ERCC3MRPL470.729255606
ERCC3PYCR20.727567303
ERCC3HPS30.725621404
ERCC3MCM60.72524711010
ERCC3SDHAF20.724944403
ERCC3SNRPG0.724784808
ERCC3SNAP470.717481303
ERCC3PGM2L10.717227404
ERCC3SMARCE10.716816403
ERCC3YWHAG0.715734404
ERCC3IWS10.715528909
ERCC3SCYL10.714922404
ERCC3PFDN20.71362510010
ERCC3FUS0.71242410010
ERCC3NASP0.710696908
ERCC3TMEM180.710602303

For details and further investigation, click here