CEBPB

 

Full name: CCAAT enhancer binding protein beta Alias Symbol: LAP|CRP2|NFIL6|IL6DBP|C/EBP-beta
Type: protein-coding gene Cytoband: 20q13.13
Entrez ID: 1051 HGNC ID: HGNC:1834 Ensembl Gene: ENSG00000172216 OMIM ID: 189965
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CEBPB involved pathways:

KEGG pathway Description View
hsa04668TNF signaling pathway
hsa05152Tuberculosis

 

Expression of CEBPB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CEBPB 1051 212501_at 0.8282 0.3093
GSE20347 CEBPB 1051 212501_at 1.0618 0.0001
GSE23400 CEBPB 1051 212501_at 0.9630 0.0000
GSE26886 CEBPB 1051 212501_at 0.9544 0.0034
GSE29001 CEBPB 1051 212501_at 1.0566 0.0007
GSE38129 CEBPB 1051 212501_at 0.9545 0.0000
GSE45670 CEBPB 1051 212501_at 0.9096 0.0008
GSE53622 CEBPB 1051 62488 1.2831 0.0000
GSE53624 CEBPB 1051 62488 1.1345 0.0000
GSE63941 CEBPB 1051 212501_at -0.4673 0.3956
GSE77861 CEBPB 1051 212501_at 1.1809 0.0045
GSE97050 CEBPB 1051 A_23_P411296 0.8244 0.1832
SRP007169 CEBPB 1051 RNAseq 0.5424 0.2715
SRP008496 CEBPB 1051 RNAseq 0.7538 0.0247
SRP064894 CEBPB 1051 RNAseq 1.4459 0.0000
SRP133303 CEBPB 1051 RNAseq 1.6442 0.0000
SRP159526 CEBPB 1051 RNAseq 1.5568 0.0063
SRP193095 CEBPB 1051 RNAseq 1.7954 0.0000
SRP219564 CEBPB 1051 RNAseq 1.0747 0.0897
TCGA CEBPB 1051 RNAseq 0.1919 0.0043

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by CEBPB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CEBPB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CEBPB 1051 17 2 11
GSE20123 CEBPB 1051 17 2 11
GSE43470 CEBPB 1051 13 0 30
GSE46452 CEBPB 1051 29 0 30
GSE47630 CEBPB 1051 24 1 15
GSE54993 CEBPB 1051 0 17 53
GSE54994 CEBPB 1051 27 0 26
GSE60625 CEBPB 1051 0 0 11
GSE74703 CEBPB 1051 11 0 25
GSE74704 CEBPB 1051 13 0 7
TCGA CEBPB 1051 47 3 46

Total number of gains: 198; Total number of losses: 25; Total Number of normals: 265.  

 

Somatic mutations of CEBPB:

 

Generating mutation plots.

 

Highly correlated genes for CEBPB:

 

Showing top 20/1641 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CEBPBSPNS10.794258303
CEBPBPLEKHM30.780116303
CEBPBFADS10.778854303
CEBPBLPCAT10.7703511011
CEBPBMAD2L20.759004404
CEBPBRAB340.753367303
CEBPBSH3PXD2B0.750765707
CEBPBTNFRSF12A0.7481811011
CEBPBENAH0.74333311011
CEBPBSPON20.740373303
CEBPBFBLIM10.737434606
CEBPBGLIS20.737321606
CEBPBLRRC8C0.734313303
CEBPBMRGBP0.73306410010
CEBPBFMNL20.732044707
CEBPBMSN0.72975812011
CEBPBTMC80.724569303
CEBPBFNDC3B0.72161611011
CEBPBHELB0.721385303
CEBPBFCGR3A0.720319303

For details and further investigation, click here