| Full name: F-box protein 46 | Alias Symbol: 20D7-FC4|Fbx46 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 23403 | HGNC ID: HGNC:25069 | Ensembl Gene: ENSG00000177051 | OMIM ID: 609117 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXO46:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXO46 | 23403 | 205310_at | 0.4522 | 0.2107 | |
| GSE20347 | FBXO46 | 23403 | 205310_at | -0.0580 | 0.7504 | |
| GSE23400 | FBXO46 | 23403 | 205310_at | 0.1474 | 0.0416 | |
| GSE26886 | FBXO46 | 23403 | 205310_at | -0.9325 | 0.0003 | |
| GSE29001 | FBXO46 | 23403 | 205310_at | -0.0182 | 0.9672 | |
| GSE38129 | FBXO46 | 23403 | 205310_at | 0.1469 | 0.1831 | |
| GSE45670 | FBXO46 | 23403 | 205310_at | 0.3937 | 0.0109 | |
| GSE53622 | FBXO46 | 23403 | 149614 | -0.2106 | 0.0651 | |
| GSE53624 | FBXO46 | 23403 | 149614 | -0.1053 | 0.2664 | |
| GSE63941 | FBXO46 | 23403 | 205310_at | 0.7768 | 0.0573 | |
| GSE77861 | FBXO46 | 23403 | 205310_at | 0.2049 | 0.2547 | |
| GSE97050 | FBXO46 | 23403 | A_23_P27744 | -0.5999 | 0.2733 | |
| SRP007169 | FBXO46 | 23403 | RNAseq | -0.9644 | 0.0137 | |
| SRP008496 | FBXO46 | 23403 | RNAseq | -0.9603 | 0.0012 | |
| SRP064894 | FBXO46 | 23403 | RNAseq | -0.1445 | 0.5059 | |
| SRP133303 | FBXO46 | 23403 | RNAseq | -0.1712 | 0.4166 | |
| SRP159526 | FBXO46 | 23403 | RNAseq | -0.1242 | 0.6310 | |
| SRP193095 | FBXO46 | 23403 | RNAseq | -0.0997 | 0.3857 | |
| SRP219564 | FBXO46 | 23403 | RNAseq | -0.3952 | 0.4282 | |
| TCGA | FBXO46 | 23403 | RNAseq | 0.0884 | 0.1181 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FBXO46 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXO46:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXO46 | 23403 | 4 | 5 | 21 | |
| GSE20123 | FBXO46 | 23403 | 4 | 4 | 22 | |
| GSE43470 | FBXO46 | 23403 | 3 | 11 | 29 | |
| GSE46452 | FBXO46 | 23403 | 45 | 1 | 13 | |
| GSE47630 | FBXO46 | 23403 | 8 | 7 | 25 | |
| GSE54993 | FBXO46 | 23403 | 17 | 4 | 49 | |
| GSE54994 | FBXO46 | 23403 | 5 | 13 | 35 | |
| GSE60625 | FBXO46 | 23403 | 9 | 0 | 2 | |
| GSE74703 | FBXO46 | 23403 | 3 | 7 | 26 | |
| GSE74704 | FBXO46 | 23403 | 4 | 2 | 14 | |
| TCGA | FBXO46 | 23403 | 16 | 15 | 65 |
Total number of gains: 118; Total number of losses: 69; Total Number of normals: 301.
Somatic mutations of FBXO46:
Generating mutation plots.
Highly correlated genes for FBXO46:
Showing top 20/231 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXO46 | SHKBP1 | 0.694274 | 4 | 0 | 4 |
| FBXO46 | WDR5 | 0.69084 | 3 | 0 | 3 |
| FBXO46 | SNIP1 | 0.684442 | 3 | 0 | 3 |
| FBXO46 | EIF1AD | 0.676012 | 3 | 0 | 3 |
| FBXO46 | MARK2 | 0.657713 | 3 | 0 | 3 |
| FBXO46 | RNF149 | 0.652413 | 4 | 0 | 4 |
| FBXO46 | TPRA1 | 0.650012 | 4 | 0 | 4 |
| FBXO46 | ARHGEF19 | 0.648291 | 4 | 0 | 4 |
| FBXO46 | HNRNPL | 0.647984 | 3 | 0 | 3 |
| FBXO46 | TCF20 | 0.644984 | 3 | 0 | 3 |
| FBXO46 | DDX18 | 0.638511 | 3 | 0 | 3 |
| FBXO46 | ARHGEF11 | 0.638221 | 4 | 0 | 3 |
| FBXO46 | MOV10 | 0.634913 | 3 | 0 | 3 |
| FBXO46 | NINL | 0.634183 | 4 | 0 | 4 |
| FBXO46 | PHF23 | 0.633395 | 4 | 0 | 4 |
| FBXO46 | SNX4 | 0.62807 | 3 | 0 | 3 |
| FBXO46 | MARK4 | 0.624858 | 5 | 0 | 5 |
| FBXO46 | RAP2B | 0.624625 | 4 | 0 | 3 |
| FBXO46 | FAM89B | 0.624383 | 4 | 0 | 4 |
| FBXO46 | SRC | 0.624342 | 6 | 0 | 4 |
For details and further investigation, click here
