| Full name: Fc fragment of IgG receptor Ia | Alias Symbol: CD64|CD64A | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 2209 | HGNC ID: HGNC:3613 | Ensembl Gene: ENSG00000150337 | OMIM ID: 146760 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FCGR1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa04666 | Fc gamma R-mediated phagocytosis | |
| hsa05140 | Leishmaniasis | |
| hsa05150 | Staphylococcus aureus infection | |
| hsa05152 | Tuberculosis |
Expression of FCGR1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FCGR1A | 2209 | 216951_at | 0.0071 | 0.9822 | |
| GSE20347 | FCGR1A | 2209 | 216951_at | 0.0246 | 0.7273 | |
| GSE23400 | FCGR1A | 2209 | 216951_at | -0.0683 | 0.0016 | |
| GSE26886 | FCGR1A | 2209 | 216951_at | 0.0991 | 0.3602 | |
| GSE29001 | FCGR1A | 2209 | 216951_at | 0.0968 | 0.5737 | |
| GSE38129 | FCGR1A | 2209 | 216951_at | -0.0349 | 0.5459 | |
| GSE45670 | FCGR1A | 2209 | 216951_at | 0.0395 | 0.5356 | |
| GSE53622 | FCGR1A | 2209 | 34043 | -0.0314 | 0.7949 | |
| GSE53624 | FCGR1A | 2209 | 34043 | -0.2082 | 0.0263 | |
| GSE63941 | FCGR1A | 2209 | 216951_at | 0.0237 | 0.8973 | |
| GSE77861 | FCGR1A | 2209 | 216951_at | -0.0493 | 0.5681 | |
| SRP064894 | FCGR1A | 2209 | RNAseq | 2.6621 | 0.0000 | |
| SRP133303 | FCGR1A | 2209 | RNAseq | 1.9717 | 0.0000 | |
| SRP159526 | FCGR1A | 2209 | RNAseq | 1.8301 | 0.0029 | |
| SRP193095 | FCGR1A | 2209 | RNAseq | 0.8289 | 0.0001 | |
| SRP219564 | FCGR1A | 2209 | RNAseq | 1.9757 | 0.0179 | |
| TCGA | FCGR1A | 2209 | RNAseq | 1.4340 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by FCGR1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FCGR1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FCGR1A | 2209 | 14 | 0 | 16 | |
| GSE20123 | FCGR1A | 2209 | 14 | 0 | 16 | |
| GSE43470 | FCGR1A | 2209 | 6 | 1 | 36 | |
| GSE46452 | FCGR1A | 2209 | 2 | 1 | 56 | |
| GSE47630 | FCGR1A | 2209 | 14 | 0 | 26 | |
| GSE54993 | FCGR1A | 2209 | 0 | 3 | 67 | |
| GSE54994 | FCGR1A | 2209 | 15 | 0 | 38 | |
| GSE60625 | FCGR1A | 2209 | 0 | 0 | 11 | |
| GSE74703 | FCGR1A | 2209 | 6 | 1 | 29 | |
| GSE74704 | FCGR1A | 2209 | 7 | 0 | 13 | |
| TCGA | FCGR1A | 2209 | 33 | 15 | 48 |
Total number of gains: 111; Total number of losses: 21; Total Number of normals: 356.
Somatic mutations of FCGR1A:
Generating mutation plots.
Highly correlated genes for FCGR1A:
Showing top 20/192 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FCGR1A | EXOG | 0.685101 | 3 | 0 | 3 |
| FCGR1A | BTBD17 | 0.638503 | 3 | 0 | 3 |
| FCGR1A | CGA | 0.632115 | 4 | 0 | 3 |
| FCGR1A | CDH2 | 0.631458 | 3 | 0 | 3 |
| FCGR1A | NPTX1 | 0.631033 | 4 | 0 | 3 |
| FCGR1A | SCGN | 0.629522 | 3 | 0 | 3 |
| FCGR1A | MYEF2 | 0.622198 | 3 | 0 | 3 |
| FCGR1A | DAB1 | 0.619098 | 4 | 0 | 4 |
| FCGR1A | NRP2 | 0.616428 | 4 | 0 | 3 |
| FCGR1A | ITGB3 | 0.614308 | 4 | 0 | 4 |
| FCGR1A | ATP6V1G2 | 0.61175 | 3 | 0 | 3 |
| FCGR1A | NPY | 0.609978 | 3 | 0 | 3 |
| FCGR1A | IL1RAPL2 | 0.604428 | 4 | 0 | 3 |
| FCGR1A | SCTR | 0.601581 | 4 | 0 | 3 |
| FCGR1A | OR7E24 | 0.599347 | 4 | 0 | 3 |
| FCGR1A | NXPE4 | 0.596316 | 4 | 0 | 3 |
| FCGR1A | GLP1R | 0.596231 | 5 | 0 | 3 |
| FCGR1A | PDZD3 | 0.5949 | 5 | 0 | 3 |
| FCGR1A | ADAM22 | 0.592638 | 4 | 0 | 3 |
| FCGR1A | PRND | 0.592475 | 3 | 0 | 3 |
For details and further investigation, click here
