| Full name: FOS like 2, AP-1 transcription factor subunit | Alias Symbol: FRA2|FLJ23306 | ||
| Type: protein-coding gene | Cytoband: 2p23.2 | ||
| Entrez ID: 2355 | HGNC ID: HGNC:3798 | Ensembl Gene: ENSG00000075426 | OMIM ID: 601575 |
| Drug and gene relationship at DGIdb | |||
FOSL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation |
Expression of FOSL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FOSL2 | 2355 | 225262_at | -0.4188 | 0.1678 | |
| GSE20347 | FOSL2 | 2355 | 218880_at | -1.0457 | 0.0000 | |
| GSE23400 | FOSL2 | 2355 | 218880_at | -0.4107 | 0.0014 | |
| GSE26886 | FOSL2 | 2355 | 225262_at | -2.7353 | 0.0000 | |
| GSE29001 | FOSL2 | 2355 | 218880_at | -0.7708 | 0.0059 | |
| GSE38129 | FOSL2 | 2355 | 218880_at | -0.7099 | 0.0028 | |
| GSE45670 | FOSL2 | 2355 | 225262_at | -0.4650 | 0.0034 | |
| GSE53622 | FOSL2 | 2355 | 162154 | -0.7512 | 0.0000 | |
| GSE53624 | FOSL2 | 2355 | 162154 | -0.9168 | 0.0000 | |
| GSE63941 | FOSL2 | 2355 | 225262_at | -0.3508 | 0.4459 | |
| GSE77861 | FOSL2 | 2355 | 225262_at | -0.2431 | 0.2995 | |
| GSE97050 | FOSL2 | 2355 | A_23_P348121 | -0.5548 | 0.2372 | |
| SRP007169 | FOSL2 | 2355 | RNAseq | -1.5996 | 0.0000 | |
| SRP008496 | FOSL2 | 2355 | RNAseq | -1.1704 | 0.0000 | |
| SRP064894 | FOSL2 | 2355 | RNAseq | -0.6692 | 0.0019 | |
| SRP133303 | FOSL2 | 2355 | RNAseq | -0.7747 | 0.0000 | |
| SRP159526 | FOSL2 | 2355 | RNAseq | -0.7269 | 0.0489 | |
| SRP193095 | FOSL2 | 2355 | RNAseq | -0.5545 | 0.0001 | |
| SRP219564 | FOSL2 | 2355 | RNAseq | -0.5784 | 0.0676 | |
| TCGA | FOSL2 | 2355 | RNAseq | -0.1612 | 0.0010 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by FOSL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FOSL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FOSL2 | 2355 | 11 | 2 | 17 | |
| GSE20123 | FOSL2 | 2355 | 11 | 2 | 17 | |
| GSE43470 | FOSL2 | 2355 | 3 | 1 | 39 | |
| GSE46452 | FOSL2 | 2355 | 2 | 4 | 53 | |
| GSE47630 | FOSL2 | 2355 | 8 | 0 | 32 | |
| GSE54993 | FOSL2 | 2355 | 0 | 6 | 64 | |
| GSE54994 | FOSL2 | 2355 | 10 | 0 | 43 | |
| GSE60625 | FOSL2 | 2355 | 0 | 3 | 8 | |
| GSE74703 | FOSL2 | 2355 | 3 | 0 | 33 | |
| GSE74704 | FOSL2 | 2355 | 9 | 1 | 10 | |
| TCGA | FOSL2 | 2355 | 36 | 2 | 58 |
Total number of gains: 93; Total number of losses: 21; Total Number of normals: 374.
Somatic mutations of FOSL2:
Generating mutation plots.
Highly correlated genes for FOSL2:
Showing top 20/1135 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FOSL2 | BNIPL | 0.756539 | 5 | 0 | 5 |
| FOSL2 | MAB21L3 | 0.718229 | 5 | 0 | 5 |
| FOSL2 | ATP6V0D1 | 0.703743 | 3 | 0 | 3 |
| FOSL2 | SPINK7 | 0.697821 | 5 | 0 | 5 |
| FOSL2 | HCG22 | 0.694853 | 5 | 0 | 5 |
| FOSL2 | SPAG17 | 0.688203 | 3 | 0 | 3 |
| FOSL2 | ALS2CL | 0.679822 | 10 | 0 | 10 |
| FOSL2 | ARHGAP27 | 0.678055 | 6 | 0 | 5 |
| FOSL2 | SERPINB1 | 0.676539 | 9 | 0 | 9 |
| FOSL2 | STRADB | 0.676451 | 6 | 0 | 5 |
| FOSL2 | TMPRSS11B | 0.674723 | 5 | 0 | 5 |
| FOSL2 | SH3GL1 | 0.674105 | 10 | 0 | 10 |
| FOSL2 | SMIM5 | 0.673436 | 6 | 0 | 5 |
| FOSL2 | RSPH3 | 0.66911 | 4 | 0 | 4 |
| FOSL2 | SYTL1 | 0.667436 | 6 | 0 | 6 |
| FOSL2 | MPP7 | 0.66536 | 6 | 0 | 5 |
| FOSL2 | A2ML1 | 0.663699 | 6 | 0 | 5 |
| FOSL2 | GYS2 | 0.662027 | 10 | 0 | 9 |
| FOSL2 | KRT78 | 0.661274 | 6 | 0 | 5 |
| FOSL2 | ASPG | 0.661051 | 5 | 0 | 5 |
For details and further investigation, click here
