| Full name: forkhead box C2 | Alias Symbol: MFH-1 | ||
| Type: protein-coding gene | Cytoband: 16q24.1 | ||
| Entrez ID: 2303 | HGNC ID: HGNC:3801 | Ensembl Gene: ENSG00000176692 | OMIM ID: 602402 |
| Drug and gene relationship at DGIdb | |||
Expression of FOXC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FOXC2 | 2303 | 239058_at | 0.3224 | 0.7815 | |
| GSE20347 | FOXC2 | 2303 | 214520_at | 0.0142 | 0.8475 | |
| GSE23400 | FOXC2 | 2303 | 214520_at | -0.0234 | 0.4053 | |
| GSE26886 | FOXC2 | 2303 | 239058_at | 1.3337 | 0.0013 | |
| GSE29001 | FOXC2 | 2303 | 214520_at | -0.0490 | 0.6818 | |
| GSE38129 | FOXC2 | 2303 | 214520_at | -0.1127 | 0.0844 | |
| GSE45670 | FOXC2 | 2303 | 239058_at | -0.3190 | 0.3988 | |
| GSE53622 | FOXC2 | 2303 | 26201 | 0.6422 | 0.0133 | |
| GSE53624 | FOXC2 | 2303 | 26201 | 0.7333 | 0.0001 | |
| GSE63941 | FOXC2 | 2303 | 239058_at | -1.3052 | 0.1922 | |
| GSE77861 | FOXC2 | 2303 | 239058_at | 0.2310 | 0.5145 | |
| GSE97050 | FOXC2 | 2303 | A_33_P3302295 | 0.4294 | 0.2181 | |
| SRP133303 | FOXC2 | 2303 | RNAseq | 0.7151 | 0.2080 | |
| SRP159526 | FOXC2 | 2303 | RNAseq | 2.3516 | 0.0096 | |
| SRP219564 | FOXC2 | 2303 | RNAseq | 3.4283 | 0.0004 | |
| TCGA | FOXC2 | 2303 | RNAseq | 1.0839 | 0.0019 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by FOXC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FOXC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FOXC2 | 2303 | 5 | 2 | 23 | |
| GSE20123 | FOXC2 | 2303 | 5 | 2 | 23 | |
| GSE43470 | FOXC2 | 2303 | 2 | 12 | 29 | |
| GSE46452 | FOXC2 | 2303 | 38 | 1 | 20 | |
| GSE47630 | FOXC2 | 2303 | 11 | 9 | 20 | |
| GSE54993 | FOXC2 | 2303 | 3 | 4 | 63 | |
| GSE54994 | FOXC2 | 2303 | 9 | 11 | 33 | |
| GSE60625 | FOXC2 | 2303 | 4 | 0 | 7 | |
| GSE74703 | FOXC2 | 2303 | 1 | 9 | 26 | |
| GSE74704 | FOXC2 | 2303 | 3 | 2 | 15 | |
| TCGA | FOXC2 | 2303 | 27 | 15 | 54 |
Total number of gains: 108; Total number of losses: 67; Total Number of normals: 313.
Somatic mutations of FOXC2:
Generating mutation plots.
Highly correlated genes for FOXC2:
Showing top 20/403 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FOXC2 | G0S2 | 0.87738 | 3 | 0 | 3 |
| FOXC2 | PROK2 | 0.762919 | 3 | 0 | 3 |
| FOXC2 | KCNMB4 | 0.761532 | 3 | 0 | 3 |
| FOXC2 | PRTFDC1 | 0.750086 | 3 | 0 | 3 |
| FOXC2 | CXCL3 | 0.743929 | 3 | 0 | 3 |
| FOXC2 | NCDN | 0.739402 | 3 | 0 | 3 |
| FOXC2 | NGF | 0.733155 | 4 | 0 | 3 |
| FOXC2 | SLC38A10 | 0.730361 | 3 | 0 | 3 |
| FOXC2 | CNTNAP1 | 0.72972 | 3 | 0 | 3 |
| FOXC2 | SLC7A6OS | 0.723873 | 3 | 0 | 3 |
| FOXC2 | SIX4 | 0.72075 | 3 | 0 | 3 |
| FOXC2 | ANGPTL4 | 0.716751 | 3 | 0 | 3 |
| FOXC2 | TBC1D16 | 0.716676 | 3 | 0 | 3 |
| FOXC2 | ST6GAL1 | 0.715945 | 3 | 0 | 3 |
| FOXC2 | ENTPD2 | 0.715713 | 4 | 0 | 4 |
| FOXC2 | GPR158 | 0.715156 | 3 | 0 | 3 |
| FOXC2 | GTSF1 | 0.712548 | 3 | 0 | 3 |
| FOXC2 | TRIM47 | 0.712104 | 3 | 0 | 3 |
| FOXC2 | TNFRSF19 | 0.710354 | 3 | 0 | 3 |
| FOXC2 | DDX60L | 0.708472 | 3 | 0 | 3 |
For details and further investigation, click here
