| Full name: ubiquitin specific peptidase 8 | Alias Symbol: HumORF8|KIAA0055|UBPY|SPG59 | ||
| Type: protein-coding gene | Cytoband: 15q21.2 | ||
| Entrez ID: 9101 | HGNC ID: HGNC:12631 | Ensembl Gene: ENSG00000138592 | OMIM ID: 603158 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of USP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP8 | 9101 | 202745_at | -0.3062 | 0.3542 | |
| GSE20347 | USP8 | 9101 | 202745_at | -0.1913 | 0.0883 | |
| GSE23400 | USP8 | 9101 | 202745_at | 0.0573 | 0.4576 | |
| GSE26886 | USP8 | 9101 | 202745_at | -0.0688 | 0.7239 | |
| GSE29001 | USP8 | 9101 | 202745_at | -0.1073 | 0.6971 | |
| GSE38129 | USP8 | 9101 | 202745_at | -0.0925 | 0.4777 | |
| GSE45670 | USP8 | 9101 | 202745_at | -0.1433 | 0.1673 | |
| GSE53622 | USP8 | 9101 | 28082 | -0.2103 | 0.0000 | |
| GSE53624 | USP8 | 9101 | 28082 | -0.2308 | 0.0067 | |
| GSE63941 | USP8 | 9101 | 202745_at | -0.2009 | 0.5271 | |
| GSE77861 | USP8 | 9101 | 202745_at | 0.0381 | 0.8964 | |
| GSE97050 | USP8 | 9101 | A_23_P129058 | -0.1571 | 0.5313 | |
| SRP007169 | USP8 | 9101 | RNAseq | -0.5365 | 0.1436 | |
| SRP008496 | USP8 | 9101 | RNAseq | -0.6306 | 0.0015 | |
| SRP064894 | USP8 | 9101 | RNAseq | -0.2585 | 0.0902 | |
| SRP133303 | USP8 | 9101 | RNAseq | -0.0382 | 0.6637 | |
| SRP159526 | USP8 | 9101 | RNAseq | -0.3837 | 0.2422 | |
| SRP193095 | USP8 | 9101 | RNAseq | -0.1885 | 0.0012 | |
| SRP219564 | USP8 | 9101 | RNAseq | -0.3549 | 0.1956 | |
| TCGA | USP8 | 9101 | RNAseq | -0.1162 | 0.0095 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by USP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP8 | 9101 | 5 | 3 | 22 | |
| GSE20123 | USP8 | 9101 | 5 | 3 | 22 | |
| GSE43470 | USP8 | 9101 | 5 | 3 | 35 | |
| GSE46452 | USP8 | 9101 | 3 | 7 | 49 | |
| GSE47630 | USP8 | 9101 | 8 | 10 | 22 | |
| GSE54993 | USP8 | 9101 | 4 | 6 | 60 | |
| GSE54994 | USP8 | 9101 | 5 | 7 | 41 | |
| GSE60625 | USP8 | 9101 | 4 | 0 | 7 | |
| GSE74703 | USP8 | 9101 | 5 | 2 | 29 | |
| GSE74704 | USP8 | 9101 | 2 | 3 | 15 | |
| TCGA | USP8 | 9101 | 9 | 16 | 71 |
Total number of gains: 55; Total number of losses: 60; Total Number of normals: 373.
Somatic mutations of USP8:
Generating mutation plots.
Highly correlated genes for USP8:
Showing top 20/502 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP8 | SWAP70 | 0.79274 | 3 | 0 | 3 |
| USP8 | CCNYL1 | 0.777832 | 3 | 0 | 3 |
| USP8 | PDLIM2 | 0.767504 | 3 | 0 | 3 |
| USP8 | TMCC1 | 0.766002 | 3 | 0 | 3 |
| USP8 | MKLN1 | 0.753895 | 3 | 0 | 3 |
| USP8 | LRIG3 | 0.753131 | 4 | 0 | 3 |
| USP8 | TBC1D20 | 0.74901 | 3 | 0 | 3 |
| USP8 | RHBDD1 | 0.746075 | 3 | 0 | 3 |
| USP8 | ARL4A | 0.739209 | 4 | 0 | 4 |
| USP8 | NR2C1 | 0.734847 | 3 | 0 | 3 |
| USP8 | CTTNBP2NL | 0.731555 | 4 | 0 | 3 |
| USP8 | RTN3 | 0.721028 | 3 | 0 | 3 |
| USP8 | EIF2S2 | 0.707497 | 3 | 0 | 3 |
| USP8 | FOXO3 | 0.707315 | 3 | 0 | 3 |
| USP8 | CRNKL1 | 0.706603 | 3 | 0 | 3 |
| USP8 | TMED10 | 0.696442 | 3 | 0 | 3 |
| USP8 | TRMT11 | 0.695922 | 4 | 0 | 4 |
| USP8 | SNAP23 | 0.695149 | 9 | 0 | 7 |
| USP8 | PPP2CB | 0.691949 | 4 | 0 | 4 |
| USP8 | TADA1 | 0.688609 | 3 | 0 | 3 |
For details and further investigation, click here
