| Full name: glucokinase regulator | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 2646 | HGNC ID: HGNC:4196 | Ensembl Gene: ENSG00000084734 | OMIM ID: 600842 |
| Drug and gene relationship at DGIdb | |||
Expression of GCKR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCKR | 2646 | 206867_at | -0.3444 | 0.2968 | |
| GSE20347 | GCKR | 2646 | 206867_at | -0.2285 | 0.0024 | |
| GSE23400 | GCKR | 2646 | 206867_at | -0.3150 | 0.0000 | |
| GSE26886 | GCKR | 2646 | 206867_at | -0.4120 | 0.0140 | |
| GSE29001 | GCKR | 2646 | 206867_at | -0.6919 | 0.0001 | |
| GSE38129 | GCKR | 2646 | 206867_at | -0.3815 | 0.0000 | |
| GSE45670 | GCKR | 2646 | 206867_at | -0.2233 | 0.1604 | |
| GSE53622 | GCKR | 2646 | 112970 | -2.1900 | 0.0000 | |
| GSE53624 | GCKR | 2646 | 112970 | -3.8867 | 0.0000 | |
| GSE63941 | GCKR | 2646 | 206867_at | 0.2384 | 0.1100 | |
| GSE77861 | GCKR | 2646 | 206867_at | -0.1350 | 0.3999 | |
| GSE97050 | GCKR | 2646 | A_23_P119886 | 0.0692 | 0.7658 | |
| SRP007169 | GCKR | 2646 | RNAseq | -5.7663 | 0.0000 | |
| SRP064894 | GCKR | 2646 | RNAseq | -2.6031 | 0.0000 | |
| SRP133303 | GCKR | 2646 | RNAseq | -2.8263 | 0.0000 | |
| SRP159526 | GCKR | 2646 | RNAseq | -3.2665 | 0.0000 | |
| SRP193095 | GCKR | 2646 | RNAseq | -2.8490 | 0.0000 | |
| TCGA | GCKR | 2646 | RNAseq | -3.6594 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by GCKR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCKR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCKR | 2646 | 11 | 2 | 17 | |
| GSE20123 | GCKR | 2646 | 11 | 2 | 17 | |
| GSE43470 | GCKR | 2646 | 3 | 1 | 39 | |
| GSE46452 | GCKR | 2646 | 2 | 4 | 53 | |
| GSE47630 | GCKR | 2646 | 8 | 0 | 32 | |
| GSE54993 | GCKR | 2646 | 0 | 6 | 64 | |
| GSE54994 | GCKR | 2646 | 10 | 0 | 43 | |
| GSE60625 | GCKR | 2646 | 0 | 3 | 8 | |
| GSE74703 | GCKR | 2646 | 3 | 0 | 33 | |
| GSE74704 | GCKR | 2646 | 9 | 1 | 10 | |
| TCGA | GCKR | 2646 | 36 | 2 | 58 |
Total number of gains: 93; Total number of losses: 21; Total Number of normals: 374.
Somatic mutations of GCKR:
Generating mutation plots.
Highly correlated genes for GCKR:
Showing top 20/1126 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCKR | VSIG2 | 0.741416 | 5 | 0 | 5 |
| GCKR | SLC10A5 | 0.738111 | 3 | 0 | 3 |
| GCKR | FNDC4 | 0.734118 | 11 | 0 | 10 |
| GCKR | EPS8L1 | 0.730334 | 10 | 0 | 9 |
| GCKR | SCNN1B | 0.727533 | 10 | 0 | 9 |
| GCKR | GYS2 | 0.726074 | 10 | 0 | 9 |
| GCKR | FAM214A | 0.72516 | 5 | 0 | 5 |
| GCKR | MAPK3 | 0.724616 | 11 | 0 | 10 |
| GCKR | DEGS2 | 0.719143 | 6 | 0 | 6 |
| GCKR | GDPD3 | 0.714576 | 10 | 0 | 9 |
| GCKR | SMAGP | 0.707207 | 9 | 0 | 9 |
| GCKR | TYRO3 | 0.706273 | 10 | 0 | 10 |
| GCKR | ANXA9 | 0.705051 | 10 | 0 | 10 |
| GCKR | HOPX | 0.704781 | 9 | 0 | 9 |
| GCKR | CYP2C18 | 0.698718 | 9 | 0 | 9 |
| GCKR | CYP2C9 | 0.697995 | 10 | 0 | 9 |
| GCKR | RECQL5 | 0.697756 | 12 | 0 | 11 |
| GCKR | CCDC12 | 0.697648 | 5 | 0 | 5 |
| GCKR | TRIP10 | 0.697115 | 11 | 0 | 10 |
| GCKR | NLRX1 | 0.696648 | 10 | 0 | 10 |
For details and further investigation, click here
