| Full name: TYRO3 protein tyrosine kinase | Alias Symbol: Dtk|Brt|Tif|Sky|Etk-2|Rek | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 7301 | HGNC ID: HGNC:12446 | Ensembl Gene: ENSG00000092445 | OMIM ID: 600341 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TYRO3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TYRO3 | 7301 | 211432_s_at | -0.3658 | 0.5680 | |
| GSE20347 | TYRO3 | 7301 | 211432_s_at | -0.8614 | 0.0000 | |
| GSE23400 | TYRO3 | 7301 | 211432_s_at | -0.7927 | 0.0000 | |
| GSE26886 | TYRO3 | 7301 | 211432_s_at | -1.4807 | 0.0000 | |
| GSE29001 | TYRO3 | 7301 | 211432_s_at | -1.0488 | 0.0001 | |
| GSE38129 | TYRO3 | 7301 | 211432_s_at | -0.8111 | 0.0001 | |
| GSE45670 | TYRO3 | 7301 | 211432_s_at | -0.5274 | 0.0438 | |
| GSE53622 | TYRO3 | 7301 | 86187 | -1.0518 | 0.0000 | |
| GSE53624 | TYRO3 | 7301 | 86187 | -1.3491 | 0.0000 | |
| GSE63941 | TYRO3 | 7301 | 211432_s_at | 0.1720 | 0.6071 | |
| GSE77861 | TYRO3 | 7301 | 211432_s_at | -0.5851 | 0.0258 | |
| GSE97050 | TYRO3 | 7301 | A_23_P54517 | -0.3716 | 0.4413 | |
| SRP007169 | TYRO3 | 7301 | RNAseq | -2.7388 | 0.0000 | |
| SRP008496 | TYRO3 | 7301 | RNAseq | -2.3505 | 0.0000 | |
| SRP064894 | TYRO3 | 7301 | RNAseq | -1.2216 | 0.0000 | |
| SRP133303 | TYRO3 | 7301 | RNAseq | -1.1084 | 0.0000 | |
| SRP159526 | TYRO3 | 7301 | RNAseq | -1.4688 | 0.0001 | |
| SRP193095 | TYRO3 | 7301 | RNAseq | -1.0425 | 0.0000 | |
| SRP219564 | TYRO3 | 7301 | RNAseq | -1.2505 | 0.0233 | |
| TCGA | TYRO3 | 7301 | RNAseq | -0.0981 | 0.1996 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by TYRO3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TYRO3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TYRO3 | 7301 | 4 | 5 | 21 | |
| GSE20123 | TYRO3 | 7301 | 4 | 5 | 21 | |
| GSE43470 | TYRO3 | 7301 | 4 | 5 | 34 | |
| GSE46452 | TYRO3 | 7301 | 3 | 7 | 49 | |
| GSE47630 | TYRO3 | 7301 | 8 | 11 | 21 | |
| GSE54993 | TYRO3 | 7301 | 4 | 6 | 60 | |
| GSE54994 | TYRO3 | 7301 | 5 | 7 | 41 | |
| GSE60625 | TYRO3 | 7301 | 4 | 0 | 7 | |
| GSE74703 | TYRO3 | 7301 | 4 | 4 | 28 | |
| GSE74704 | TYRO3 | 7301 | 3 | 3 | 14 | |
| TCGA | TYRO3 | 7301 | 11 | 18 | 67 |
Total number of gains: 54; Total number of losses: 71; Total Number of normals: 363.
Somatic mutations of TYRO3:
Generating mutation plots.
Highly correlated genes for TYRO3:
Showing top 20/1197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TYRO3 | NCCRP1 | 0.831683 | 3 | 0 | 3 |
| TYRO3 | EVPL | 0.807654 | 11 | 0 | 11 |
| TYRO3 | FNDC4 | 0.804779 | 11 | 0 | 11 |
| TYRO3 | SH3GL1 | 0.800225 | 10 | 0 | 10 |
| TYRO3 | MPZL3 | 0.79047 | 6 | 0 | 6 |
| TYRO3 | TMPRSS11E | 0.787997 | 10 | 0 | 10 |
| TYRO3 | KPRP | 0.786557 | 3 | 0 | 3 |
| TYRO3 | MALL | 0.783795 | 11 | 0 | 11 |
| TYRO3 | TOM1 | 0.782376 | 10 | 0 | 10 |
| TYRO3 | NLRX1 | 0.782269 | 9 | 0 | 9 |
| TYRO3 | EHD3 | 0.781953 | 10 | 0 | 10 |
| TYRO3 | MUC22 | 0.7793 | 3 | 0 | 3 |
| TYRO3 | AIF1L | 0.778375 | 7 | 0 | 7 |
| TYRO3 | GDPD3 | 0.77581 | 11 | 0 | 11 |
| TYRO3 | ALS2CL | 0.774255 | 11 | 0 | 11 |
| TYRO3 | SLURP1 | 0.773916 | 11 | 0 | 11 |
| TYRO3 | GYS2 | 0.773638 | 10 | 0 | 10 |
| TYRO3 | ESPL1 | 0.770863 | 11 | 0 | 11 |
| TYRO3 | C15orf62 | 0.769146 | 5 | 0 | 5 |
| TYRO3 | ENDOU | 0.768666 | 11 | 0 | 11 |
For details and further investigation, click here
