TGFB3

 

Full name: transforming growth factor beta 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 14q24
Entrez ID: 7043 HGNC ID: HGNC:11769 Ensembl Gene: ENSG00000119699 OMIM ID: 190230
Drug and gene relationship at DGIdb

 

TGFB3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa05321Inflammatory bowel disease (IBD)

 

Expression of TGFB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TGFB3 7043 209747_at 0.1002 0.8664
GSE20347 TGFB3 7043 209747_at 0.2817 0.0290
GSE23400 TGFB3 7043 209747_at 0.1708 0.0002
GSE26886 TGFB3 7043 209747_at 0.5276 0.0328
GSE29001 TGFB3 7043 209747_at 0.5606 0.0300
GSE38129 TGFB3 7043 209747_at 0.1845 0.2875
GSE45670 TGFB3 7043 209747_at -0.0409 0.8750
GSE53622 TGFB3 7043 108220 0.9499 0.0000
GSE53624 TGFB3 7043 108220 1.0239 0.0000
GSE63941 TGFB3 7043 209747_at -0.5185 0.0270
GSE77861 TGFB3 7043 209747_at 0.1888 0.3222
GSE97050 TGFB3 7043 A_23_P88404 0.3129 0.2956
SRP007169 TGFB3 7043 RNAseq 2.5680 0.0030
SRP064894 TGFB3 7043 RNAseq 1.2415 0.0000
SRP133303 TGFB3 7043 RNAseq 0.9447 0.0029
SRP159526 TGFB3 7043 RNAseq 0.3469 0.3228
SRP193095 TGFB3 7043 RNAseq 1.4331 0.0000
SRP219564 TGFB3 7043 RNAseq 1.3322 0.0413
TCGA TGFB3 7043 RNAseq -0.1907 0.1117

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by TGFB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TGFB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TGFB3 7043 8 3 19
GSE20123 TGFB3 7043 8 3 19
GSE43470 TGFB3 7043 8 3 32
GSE46452 TGFB3 7043 16 3 40
GSE47630 TGFB3 7043 11 8 21
GSE54993 TGFB3 7043 3 8 59
GSE54994 TGFB3 7043 19 4 30
GSE60625 TGFB3 7043 0 2 9
GSE74703 TGFB3 7043 7 3 26
GSE74704 TGFB3 7043 3 3 14
TCGA TGFB3 7043 31 16 49

Total number of gains: 114; Total number of losses: 56; Total Number of normals: 318.  

 

Somatic mutations of TGFB3:

 

Generating mutation plots.

 

Highly correlated genes for TGFB3:

 

Showing top 20/786 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TGFB3ICAM50.805215303
TGFB3FCGR3A0.762856303
TGFB3LRRC8C0.742233303
TGFB3GDF60.736062303
TGFB3FLT10.708851303
TGFB3RAB340.707347303
TGFB3SLC29A30.707279303
TGFB3NNMT0.704545404
TGFB3SUCNR10.686727404
TGFB3SPON20.685265403
TGFB3TIMP40.684495403
TGFB3GLIS30.681514808
TGFB3RGS180.680588303
TGFB3CATSPER10.674939303
TGFB3SLC41A20.672509504
TGFB3PTPRD0.670604403
TGFB3DEXI0.667786303
TGFB3DNAJA10.664926303
TGFB3LRRC170.66263612010
TGFB3PRR160.661899908

For details and further investigation, click here