| Full name: gamma-glutamyl hydrolase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q12.3 | ||
| Entrez ID: 8836 | HGNC ID: HGNC:4248 | Ensembl Gene: ENSG00000137563 | OMIM ID: 601509 |
| Drug and gene relationship at DGIdb | |||
Expression of GGH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GGH | 8836 | 203560_at | 1.2957 | 0.1529 | |
| GSE20347 | GGH | 8836 | 203560_at | 1.1051 | 0.0001 | |
| GSE23400 | GGH | 8836 | 203560_at | 1.2687 | 0.0000 | |
| GSE26886 | GGH | 8836 | 203560_at | 0.1941 | 0.5019 | |
| GSE29001 | GGH | 8836 | 203560_at | 1.2346 | 0.0060 | |
| GSE38129 | GGH | 8836 | 203560_at | 1.7173 | 0.0000 | |
| GSE45670 | GGH | 8836 | 203560_at | 1.0510 | 0.0007 | |
| GSE53622 | GGH | 8836 | 4334 | 0.8141 | 0.0000 | |
| GSE53624 | GGH | 8836 | 4334 | 1.0340 | 0.0000 | |
| GSE63941 | GGH | 8836 | 203560_at | 0.6453 | 0.4302 | |
| GSE77861 | GGH | 8836 | 203560_at | 0.7356 | 0.2359 | |
| GSE97050 | GGH | 8836 | A_33_P3308105 | 0.4792 | 0.3961 | |
| SRP007169 | GGH | 8836 | RNAseq | 0.2191 | 0.5174 | |
| SRP008496 | GGH | 8836 | RNAseq | 0.3448 | 0.2396 | |
| SRP064894 | GGH | 8836 | RNAseq | 1.5951 | 0.0000 | |
| SRP133303 | GGH | 8836 | RNAseq | 0.8678 | 0.0004 | |
| SRP159526 | GGH | 8836 | RNAseq | 0.9790 | 0.0000 | |
| SRP193095 | GGH | 8836 | RNAseq | 0.2300 | 0.3463 | |
| SRP219564 | GGH | 8836 | RNAseq | 0.9297 | 0.1241 | |
| TCGA | GGH | 8836 | RNAseq | 0.6643 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by GGH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GGH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GGH | 8836 | 13 | 1 | 16 | |
| GSE20123 | GGH | 8836 | 13 | 1 | 16 | |
| GSE43470 | GGH | 8836 | 15 | 3 | 25 | |
| GSE46452 | GGH | 8836 | 21 | 1 | 37 | |
| GSE47630 | GGH | 8836 | 23 | 1 | 16 | |
| GSE54993 | GGH | 8836 | 1 | 18 | 51 | |
| GSE54994 | GGH | 8836 | 30 | 0 | 23 | |
| GSE60625 | GGH | 8836 | 0 | 4 | 7 | |
| GSE74703 | GGH | 8836 | 13 | 2 | 21 | |
| GSE74704 | GGH | 8836 | 9 | 0 | 11 | |
| TCGA | GGH | 8836 | 45 | 6 | 45 |
Total number of gains: 183; Total number of losses: 37; Total Number of normals: 268.
Somatic mutations of GGH:
Generating mutation plots.
Highly correlated genes for GGH:
Showing top 20/1482 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GGH | KREMEN1 | 0.774251 | 3 | 0 | 3 |
| GGH | TNFRSF21 | 0.747881 | 3 | 0 | 3 |
| GGH | MCM4 | 0.742521 | 12 | 0 | 11 |
| GGH | ARHGEF19 | 0.73606 | 3 | 0 | 3 |
| GGH | PRKDC | 0.725168 | 12 | 0 | 11 |
| GGH | CCNB1 | 0.723195 | 12 | 0 | 10 |
| GGH | TTK | 0.723004 | 12 | 0 | 12 |
| GGH | FZD6 | 0.720437 | 8 | 0 | 8 |
| GGH | KIF23 | 0.720249 | 13 | 0 | 13 |
| GGH | PBK | 0.719343 | 13 | 0 | 12 |
| GGH | KIF20A | 0.713713 | 12 | 0 | 11 |
| GGH | ASPM | 0.712983 | 13 | 0 | 11 |
| GGH | CENPF | 0.711184 | 12 | 0 | 10 |
| GGH | CCT6A | 0.710642 | 8 | 0 | 7 |
| GGH | ATAD2 | 0.708172 | 13 | 0 | 12 |
| GGH | GINS1 | 0.707972 | 12 | 0 | 11 |
| GGH | MTERF3 | 0.707875 | 7 | 0 | 7 |
| GGH | CDK1 | 0.705293 | 12 | 0 | 11 |
| GGH | MAD2L1 | 0.704788 | 13 | 0 | 12 |
| GGH | HMMR | 0.704215 | 12 | 0 | 10 |
For details and further investigation, click here
