| Full name: glutaminase 2 | Alias Symbol: GA|GLS|LGA|hLGA | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 27165 | HGNC ID: HGNC:29570 | Ensembl Gene: ENSG00000135423 | OMIM ID: 606365 |
| Drug and gene relationship at DGIdb | |||
Expression of GLS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLS2 | 27165 | 205531_s_at | -0.1403 | 0.7628 | |
| GSE20347 | GLS2 | 27165 | 205531_s_at | 0.1755 | 0.4679 | |
| GSE23400 | GLS2 | 27165 | 205531_s_at | -0.0745 | 0.1145 | |
| GSE26886 | GLS2 | 27165 | 205531_s_at | 0.2447 | 0.3822 | |
| GSE29001 | GLS2 | 27165 | 205531_s_at | -0.1880 | 0.4777 | |
| GSE38129 | GLS2 | 27165 | 205531_s_at | 0.3126 | 0.1618 | |
| GSE45670 | GLS2 | 27165 | 205531_s_at | -0.2563 | 0.3624 | |
| GSE63941 | GLS2 | 27165 | 205531_s_at | 1.7609 | 0.0632 | |
| GSE77861 | GLS2 | 27165 | 205531_s_at | 0.2016 | 0.5116 | |
| GSE97050 | GLS2 | 27165 | A_24_P326739 | -0.0049 | 0.9936 | |
| SRP007169 | GLS2 | 27165 | RNAseq | 1.1266 | 0.0688 | |
| SRP064894 | GLS2 | 27165 | RNAseq | -1.2496 | 0.0015 | |
| SRP133303 | GLS2 | 27165 | RNAseq | 0.1750 | 0.7887 | |
| SRP159526 | GLS2 | 27165 | RNAseq | -0.1136 | 0.8185 | |
| SRP193095 | GLS2 | 27165 | RNAseq | -0.2190 | 0.5427 | |
| SRP219564 | GLS2 | 27165 | RNAseq | -1.0051 | 0.2764 | |
| TCGA | GLS2 | 27165 | RNAseq | -0.0133 | 0.9520 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GLS2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GLS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLS2 | 27165 | 7 | 2 | 21 | |
| GSE20123 | GLS2 | 27165 | 7 | 1 | 22 | |
| GSE43470 | GLS2 | 27165 | 3 | 0 | 40 | |
| GSE46452 | GLS2 | 27165 | 8 | 1 | 50 | |
| GSE47630 | GLS2 | 27165 | 10 | 2 | 28 | |
| GSE54993 | GLS2 | 27165 | 0 | 5 | 65 | |
| GSE54994 | GLS2 | 27165 | 4 | 1 | 48 | |
| GSE60625 | GLS2 | 27165 | 0 | 0 | 11 | |
| GSE74703 | GLS2 | 27165 | 3 | 0 | 33 | |
| GSE74704 | GLS2 | 27165 | 4 | 1 | 15 | |
| TCGA | GLS2 | 27165 | 14 | 10 | 72 |
Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.
Somatic mutations of GLS2:
Generating mutation plots.
Highly correlated genes for GLS2:
Showing top 20/63 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLS2 | LINC01139 | 0.684294 | 3 | 0 | 3 |
| GLS2 | FAM227B | 0.671216 | 3 | 0 | 3 |
| GLS2 | KCNE3 | 0.659286 | 4 | 0 | 4 |
| GLS2 | TUBE1 | 0.640675 | 3 | 0 | 3 |
| GLS2 | SORL1 | 0.635065 | 5 | 0 | 4 |
| GLS2 | PCDH19 | 0.624857 | 5 | 0 | 5 |
| GLS2 | IFT172 | 0.619178 | 4 | 0 | 3 |
| GLS2 | CS | 0.616128 | 3 | 0 | 3 |
| GLS2 | KIAA1671 | 0.599751 | 3 | 0 | 3 |
| GLS2 | SOX2-OT | 0.597233 | 4 | 0 | 3 |
| GLS2 | BEGAIN | 0.59716 | 3 | 0 | 3 |
| GLS2 | OCA2 | 0.593309 | 4 | 0 | 3 |
| GLS2 | ICK | 0.588061 | 5 | 0 | 3 |
| GLS2 | MECP2 | 0.587236 | 3 | 0 | 3 |
| GLS2 | MSI2 | 0.5858 | 4 | 0 | 3 |
| GLS2 | DENND4A | 0.58413 | 4 | 0 | 3 |
| GLS2 | NTS | 0.584012 | 4 | 0 | 3 |
| GLS2 | AGBL5 | 0.580853 | 4 | 0 | 4 |
| GLS2 | SUPT4H1 | 0.577237 | 3 | 0 | 3 |
| GLS2 | MRAP2 | 0.572201 | 4 | 0 | 3 |
For details and further investigation, click here
