GNB1

 

Full name: G protein subunit beta 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 1p36.33
Entrez ID: 2782 HGNC ID: HGNC:4396 Ensembl Gene: ENSG00000078369 OMIM ID: 139380
Drug and gene relationship at DGIdb
Screen Evidence:

 

GNB1 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNB1 2782 200746_s_at 0.3323 0.2809
GSE20347 GNB1 2782 200746_s_at 0.2836 0.0430
GSE23400 GNB1 2782 200746_s_at 0.5128 0.0000
GSE26886 GNB1 2782 200746_s_at 0.3160 0.2069
GSE29001 GNB1 2782 200745_s_at 0.2466 0.3115
GSE38129 GNB1 2782 200746_s_at 0.2755 0.0193
GSE45670 GNB1 2782 200746_s_at -0.0268 0.8929
GSE53622 GNB1 2782 34733 0.1746 0.0079
GSE53624 GNB1 2782 34733 0.2180 0.0003
GSE63941 GNB1 2782 200746_s_at -0.0261 0.9500
GSE77861 GNB1 2782 200746_s_at 0.4148 0.1857
GSE97050 GNB1 2782 A_23_P22926 0.1842 0.4785
SRP007169 GNB1 2782 RNAseq -0.2263 0.5449
SRP008496 GNB1 2782 RNAseq 0.0469 0.8291
SRP064894 GNB1 2782 RNAseq 0.6303 0.0000
SRP133303 GNB1 2782 RNAseq 0.6569 0.0013
SRP159526 GNB1 2782 RNAseq 0.4157 0.0350
SRP193095 GNB1 2782 RNAseq 0.2399 0.0515
SRP219564 GNB1 2782 RNAseq 0.1415 0.6822
TCGA GNB1 2782 RNAseq 0.0271 0.4697

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GNB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNB1 2782 4 7 19
GSE20123 GNB1 2782 4 6 20
GSE43470 GNB1 2782 3 5 35
GSE46452 GNB1 2782 7 1 51
GSE47630 GNB1 2782 8 4 28
GSE54993 GNB1 2782 2 2 66
GSE54994 GNB1 2782 15 2 36
GSE60625 GNB1 2782 0 0 11
GSE74703 GNB1 2782 3 3 30
GSE74704 GNB1 2782 4 0 16
TCGA GNB1 2782 14 20 62

Total number of gains: 64; Total number of losses: 50; Total Number of normals: 374.  

 

Somatic mutations of GNB1:

 

Generating mutation plots.

 

Highly correlated genes for GNB1:

 

Showing top 20/858 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNB1AGBL50.76562303
GNB1TRAP10.752845303
GNB1ATG4C0.744073303
GNB1IFNAR10.742809303
GNB1POLR2J0.739425403
GNB1DNAJC190.736218303
GNB1TSEN150.733159303
GNB1CD1090.721701303
GNB1PTGES20.715405303
GNB1PEG100.713405303
GNB1PPP1R350.712821403
GNB1STX160.709728303
GNB1DOCK110.700351303
GNB1MRPS340.699326403
GNB1NIPA20.696862303
GNB1NEURL1B0.695843303
GNB1STAT5B0.695616303
GNB1KLHL360.695231303
GNB1USP340.693193403
GNB1RFTN20.690313303

For details and further investigation, click here