POP7

 

Full name: POP7 homolog, ribonuclease P/MRP subunit Alias Symbol: RPP20|RPP2
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 10248 HGNC ID: HGNC:19949 Ensembl Gene: ENSG00000172336 OMIM ID: 606113
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of POP7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POP7 10248 209482_at 0.8200 0.0939
GSE20347 POP7 10248 209482_at 0.6059 0.0006
GSE23400 POP7 10248 209482_at 0.5704 0.0000
GSE26886 POP7 10248 209482_at 1.6109 0.0000
GSE29001 POP7 10248 209482_at 0.4382 0.0189
GSE38129 POP7 10248 209482_at 0.7693 0.0000
GSE45670 POP7 10248 209482_at 0.4991 0.0052
GSE53622 POP7 10248 136873 0.5074 0.0000
GSE53624 POP7 10248 136873 0.8103 0.0000
GSE63941 POP7 10248 209482_at 0.5409 0.2080
GSE77861 POP7 10248 209482_at 0.5651 0.0046
GSE97050 POP7 10248 A_23_P134274 0.1827 0.3915
SRP007169 POP7 10248 RNAseq -0.5045 0.1946
SRP008496 POP7 10248 RNAseq -0.0244 0.9411
SRP064894 POP7 10248 RNAseq 0.6109 0.0604
SRP133303 POP7 10248 RNAseq 0.7446 0.0007
SRP159526 POP7 10248 RNAseq 0.2982 0.1727
SRP193095 POP7 10248 RNAseq 0.5616 0.0015
SRP219564 POP7 10248 RNAseq 0.5933 0.0079
TCGA POP7 10248 RNAseq 0.3389 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by POP7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POP7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POP7 10248 13 0 17
GSE20123 POP7 10248 13 0 17
GSE43470 POP7 10248 7 2 34
GSE46452 POP7 10248 11 1 47
GSE47630 POP7 10248 7 3 30
GSE54993 POP7 10248 1 9 60
GSE54994 POP7 10248 16 3 34
GSE60625 POP7 10248 0 0 11
GSE74703 POP7 10248 7 1 28
GSE74704 POP7 10248 9 0 11
TCGA POP7 10248 53 6 37

Total number of gains: 137; Total number of losses: 25; Total Number of normals: 326.  

 

Somatic mutations of POP7:

 

Generating mutation plots.

 

Highly correlated genes for POP7:

 

Showing top 20/1827 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POP7POU5F20.792858303
POP7MCM70.79181812012
POP7PPP1R350.783572808
POP7PSMC20.76180512012
POP7LAMTOR40.753223606
POP7OSR20.748904303
POP7UBE2T0.745608808
POP7PUS70.74480713013
POP7YDJC0.744737606
POP7CYSTM10.739912303
POP7BLACAT10.734655303
POP7SIX40.732027707
POP7DNMT10.72131312011
POP7PCIF10.719655303
POP7MYBL20.71842212012
POP7DBF40.71694511011
POP7CEP550.71475811011
POP7KNSTRN0.713235706
POP7LSM40.71270111010
POP7CDK40.71225211011

For details and further investigation, click here