| Full name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Alias Symbol: Uae1 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 10020 | HGNC ID: HGNC:23657 | Ensembl Gene: ENSG00000159921 | OMIM ID: 603824 |
| Drug and gene relationship at DGIdb | |||
Expression of GNE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNE | 10020 | 205042_at | -1.3288 | 0.0309 | |
| GSE20347 | GNE | 10020 | 205042_at | -1.3239 | 0.0000 | |
| GSE23400 | GNE | 10020 | 205042_at | -0.5909 | 0.0000 | |
| GSE26886 | GNE | 10020 | 205042_at | -2.3447 | 0.0000 | |
| GSE29001 | GNE | 10020 | 205042_at | -1.1196 | 0.0025 | |
| GSE38129 | GNE | 10020 | 205042_at | -1.1453 | 0.0000 | |
| GSE45670 | GNE | 10020 | 205042_at | -0.8437 | 0.0219 | |
| GSE53622 | GNE | 10020 | 60373 | -1.0482 | 0.0000 | |
| GSE53624 | GNE | 10020 | 60373 | -1.2327 | 0.0000 | |
| GSE63941 | GNE | 10020 | 205042_at | -1.7694 | 0.1665 | |
| GSE77861 | GNE | 10020 | 205042_at | -1.0665 | 0.0152 | |
| GSE97050 | GNE | 10020 | A_23_P216489 | -0.9837 | 0.0969 | |
| SRP007169 | GNE | 10020 | RNAseq | -2.1675 | 0.0000 | |
| SRP008496 | GNE | 10020 | RNAseq | -1.9365 | 0.0000 | |
| SRP064894 | GNE | 10020 | RNAseq | -1.5728 | 0.0000 | |
| SRP133303 | GNE | 10020 | RNAseq | -1.0146 | 0.0000 | |
| SRP159526 | GNE | 10020 | RNAseq | -1.4307 | 0.0000 | |
| SRP193095 | GNE | 10020 | RNAseq | -1.0278 | 0.0000 | |
| SRP219564 | GNE | 10020 | RNAseq | -1.2740 | 0.0195 | |
| TCGA | GNE | 10020 | RNAseq | -0.2732 | 0.0021 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by GNE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNE | 10020 | 3 | 11 | 16 | |
| GSE20123 | GNE | 10020 | 3 | 11 | 16 | |
| GSE43470 | GNE | 10020 | 3 | 10 | 30 | |
| GSE46452 | GNE | 10020 | 6 | 15 | 38 | |
| GSE47630 | GNE | 10020 | 1 | 20 | 19 | |
| GSE54993 | GNE | 10020 | 6 | 0 | 64 | |
| GSE54994 | GNE | 10020 | 5 | 12 | 36 | |
| GSE60625 | GNE | 10020 | 0 | 0 | 11 | |
| GSE74703 | GNE | 10020 | 2 | 7 | 27 | |
| GSE74704 | GNE | 10020 | 0 | 9 | 11 | |
| TCGA | GNE | 10020 | 15 | 44 | 37 |
Total number of gains: 44; Total number of losses: 139; Total Number of normals: 305.
Somatic mutations of GNE:
Generating mutation plots.
Highly correlated genes for GNE:
Showing top 20/1420 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNE | SH3BGRL2 | 0.748304 | 7 | 0 | 7 |
| GNE | UBQLN1 | 0.747589 | 3 | 0 | 3 |
| GNE | RNF185 | 0.74758 | 3 | 0 | 3 |
| GNE | CA13 | 0.746527 | 3 | 0 | 3 |
| GNE | GPRC5B | 0.745775 | 3 | 0 | 3 |
| GNE | FCHO2 | 0.736161 | 7 | 0 | 7 |
| GNE | IMPACT | 0.735846 | 3 | 0 | 3 |
| GNE | ANXA9 | 0.734286 | 11 | 0 | 10 |
| GNE | C15orf62 | 0.733981 | 7 | 0 | 7 |
| GNE | FAM3D | 0.731492 | 6 | 0 | 6 |
| GNE | KLHL29 | 0.722065 | 3 | 0 | 3 |
| GNE | HDHD2 | 0.721666 | 5 | 0 | 5 |
| GNE | PRPF38A | 0.718235 | 3 | 0 | 3 |
| GNE | KLHDC7A | 0.716161 | 3 | 0 | 3 |
| GNE | KAT2B | 0.714794 | 11 | 0 | 11 |
| GNE | FLG-AS1 | 0.71192 | 6 | 0 | 6 |
| GNE | CGNL1 | 0.711699 | 7 | 0 | 6 |
| GNE | FAM214A | 0.709199 | 6 | 0 | 6 |
| GNE | CPEB3 | 0.702992 | 10 | 0 | 10 |
| GNE | ACADM | 0.698531 | 11 | 0 | 11 |
For details and further investigation, click here
