| Full name: recombination activating 1 | Alias Symbol: RNF74|MGC43321 | ||
| Type: protein-coding gene | Cytoband: 11p12 | ||
| Entrez ID: 5896 | HGNC ID: HGNC:9831 | Ensembl Gene: ENSG00000166349 | OMIM ID: 179615 |
| Drug and gene relationship at DGIdb | |||
RAG1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of RAG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAG1 | 5896 | 206591_at | 0.3884 | 0.1299 | |
| GSE20347 | RAG1 | 5896 | 206591_at | 0.3183 | 0.0003 | |
| GSE23400 | RAG1 | 5896 | 206591_at | 0.0889 | 0.0001 | |
| GSE26886 | RAG1 | 5896 | 206591_at | 0.6235 | 0.0029 | |
| GSE29001 | RAG1 | 5896 | 206591_at | 0.5567 | 0.0060 | |
| GSE38129 | RAG1 | 5896 | 206591_at | 0.3093 | 0.0000 | |
| GSE45670 | RAG1 | 5896 | 206591_at | 0.9096 | 0.0051 | |
| GSE63941 | RAG1 | 5896 | 206591_at | 0.5587 | 0.0848 | |
| GSE77861 | RAG1 | 5896 | 206591_at | 0.1449 | 0.3084 | |
| SRP007169 | RAG1 | 5896 | RNAseq | 3.6648 | 0.0002 | |
| SRP008496 | RAG1 | 5896 | RNAseq | 5.0517 | 0.0000 | |
| SRP133303 | RAG1 | 5896 | RNAseq | 3.1205 | 0.0000 | |
| SRP159526 | RAG1 | 5896 | RNAseq | 2.0896 | 0.0000 | |
| SRP219564 | RAG1 | 5896 | RNAseq | 3.6694 | 0.0000 | |
| TCGA | RAG1 | 5896 | RNAseq | 0.8391 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by RAG1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RAG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAG1 | 5896 | 0 | 8 | 22 | |
| GSE20123 | RAG1 | 5896 | 0 | 7 | 23 | |
| GSE43470 | RAG1 | 5896 | 3 | 4 | 36 | |
| GSE46452 | RAG1 | 5896 | 7 | 5 | 47 | |
| GSE47630 | RAG1 | 5896 | 3 | 10 | 27 | |
| GSE54993 | RAG1 | 5896 | 3 | 2 | 65 | |
| GSE54994 | RAG1 | 5896 | 3 | 10 | 40 | |
| GSE60625 | RAG1 | 5896 | 0 | 0 | 11 | |
| GSE74703 | RAG1 | 5896 | 2 | 2 | 32 | |
| GSE74704 | RAG1 | 5896 | 0 | 5 | 15 | |
| TCGA | RAG1 | 5896 | 12 | 22 | 62 |
Total number of gains: 33; Total number of losses: 75; Total Number of normals: 380.
Somatic mutations of RAG1:
Generating mutation plots.
Highly correlated genes for RAG1:
Showing top 20/308 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAG1 | RFC3 | 0.72101 | 3 | 0 | 3 |
| RAG1 | NOSIP | 0.697708 | 3 | 0 | 3 |
| RAG1 | MRPL47 | 0.690857 | 3 | 0 | 3 |
| RAG1 | TACC3 | 0.690725 | 3 | 0 | 3 |
| RAG1 | CCDC18 | 0.689162 | 3 | 0 | 3 |
| RAG1 | TMEM9 | 0.67853 | 3 | 0 | 3 |
| RAG1 | NDUFB9 | 0.676121 | 3 | 0 | 3 |
| RAG1 | AMDHD1 | 0.675896 | 3 | 0 | 3 |
| RAG1 | LINC01116 | 0.654621 | 3 | 0 | 3 |
| RAG1 | SLBP | 0.647015 | 3 | 0 | 3 |
| RAG1 | DONSON | 0.643433 | 3 | 0 | 3 |
| RAG1 | FLVCR1 | 0.643395 | 3 | 0 | 3 |
| RAG1 | HOXC13 | 0.638498 | 3 | 0 | 3 |
| RAG1 | FANCA | 0.635966 | 5 | 0 | 3 |
| RAG1 | GNGT1 | 0.634271 | 5 | 0 | 5 |
| RAG1 | TRAPPC3L | 0.630404 | 3 | 0 | 3 |
| RAG1 | WDR53 | 0.625892 | 4 | 0 | 3 |
| RAG1 | LRRC58 | 0.625193 | 3 | 0 | 3 |
| RAG1 | MED30 | 0.62014 | 3 | 0 | 3 |
| RAG1 | ERCC3 | 0.618999 | 4 | 0 | 3 |
For details and further investigation, click here
