| Full name: glycoprotein VI platelet | Alias Symbol: GPVI | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 51206 | HGNC ID: HGNC:14388 | Ensembl Gene: ENSG00000088053 | OMIM ID: 605546 |
| Drug and gene relationship at DGIdb | |||
GP6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04611 | Platelet activation |
Expression of GP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GP6 | 51206 | 220336_s_at | 0.0208 | 0.9498 | |
| GSE20347 | GP6 | 51206 | 220336_s_at | 0.0051 | 0.9626 | |
| GSE23400 | GP6 | 51206 | 220336_s_at | -0.0992 | 0.0002 | |
| GSE26886 | GP6 | 51206 | 220336_s_at | 0.0276 | 0.8549 | |
| GSE29001 | GP6 | 51206 | 220336_s_at | -0.2046 | 0.1770 | |
| GSE38129 | GP6 | 51206 | 220336_s_at | -0.0994 | 0.3892 | |
| GSE45670 | GP6 | 51206 | 220336_s_at | -0.0788 | 0.6785 | |
| GSE53622 | GP6 | 51206 | 18966 | -0.9148 | 0.0000 | |
| GSE53624 | GP6 | 51206 | 18966 | -1.4223 | 0.0000 | |
| GSE63941 | GP6 | 51206 | 220336_s_at | 0.0836 | 0.5702 | |
| GSE77861 | GP6 | 51206 | 220336_s_at | -0.0320 | 0.7860 | |
| GSE97050 | GP6 | 51206 | A_33_P3461416 | -0.1993 | 0.6066 | |
| SRP133303 | GP6 | 51206 | RNAseq | -0.1485 | 0.4860 | |
| SRP159526 | GP6 | 51206 | RNAseq | -2.1128 | 0.0000 | |
| SRP193095 | GP6 | 51206 | RNAseq | -0.4074 | 0.0287 | |
| SRP219564 | GP6 | 51206 | RNAseq | -1.9888 | 0.0066 | |
| TCGA | GP6 | 51206 | RNAseq | -0.4994 | 0.2390 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by GP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GP6 | 51206 | 3 | 4 | 23 | |
| GSE20123 | GP6 | 51206 | 3 | 3 | 24 | |
| GSE43470 | GP6 | 51206 | 3 | 11 | 29 | |
| GSE46452 | GP6 | 51206 | 45 | 1 | 13 | |
| GSE47630 | GP6 | 51206 | 8 | 6 | 26 | |
| GSE54993 | GP6 | 51206 | 17 | 4 | 49 | |
| GSE54994 | GP6 | 51206 | 4 | 13 | 36 | |
| GSE60625 | GP6 | 51206 | 9 | 0 | 2 | |
| GSE74703 | GP6 | 51206 | 3 | 7 | 26 | |
| GSE74704 | GP6 | 51206 | 3 | 1 | 16 | |
| TCGA | GP6 | 51206 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of GP6:
Generating mutation plots.
Highly correlated genes for GP6:
Showing top 20/554 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GP6 | ULK3 | 0.712423 | 4 | 0 | 4 |
| GP6 | NIPAL1 | 0.697377 | 3 | 0 | 3 |
| GP6 | NUAK2 | 0.695863 | 3 | 0 | 3 |
| GP6 | ARHGAP27 | 0.695189 | 4 | 0 | 4 |
| GP6 | NAGK | 0.684304 | 4 | 0 | 4 |
| GP6 | MPZL3 | 0.674421 | 4 | 0 | 4 |
| GP6 | OTUD7B | 0.672886 | 3 | 0 | 3 |
| GP6 | DAGLA | 0.668825 | 3 | 0 | 3 |
| GP6 | RASAL2 | 0.668756 | 4 | 0 | 3 |
| GP6 | RB1CC1 | 0.668154 | 3 | 0 | 3 |
| GP6 | KLHL29 | 0.665715 | 4 | 0 | 4 |
| GP6 | EPGN | 0.663284 | 3 | 0 | 3 |
| GP6 | CHRM5 | 0.662839 | 4 | 0 | 3 |
| GP6 | VAX2 | 0.66282 | 3 | 0 | 3 |
| GP6 | SLC10A5 | 0.662533 | 3 | 0 | 3 |
| GP6 | SLC46A2 | 0.661405 | 4 | 0 | 4 |
| GP6 | PRSS27 | 0.660734 | 3 | 0 | 3 |
| GP6 | PLEKHM1 | 0.657828 | 5 | 0 | 4 |
| GP6 | MIEF2 | 0.655949 | 3 | 0 | 3 |
| GP6 | RNF10 | 0.654477 | 6 | 0 | 6 |
For details and further investigation, click here
