| Full name: G protein-coupled estrogen receptor 1 | Alias Symbol: FEG-1|GPCR-Br|LERGU|LERGU2|DRY12|LyGPR|CEPR | ||
| Type: protein-coding gene | Cytoband: 7p22.3 | ||
| Entrez ID: 2852 | HGNC ID: HGNC:4485 | Ensembl Gene: ENSG00000164850 | OMIM ID: 601805 |
| Drug and gene relationship at DGIdb | |||
GPER1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04915 | Estrogen signaling pathway |
Expression of GPER1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPER1 | 2852 | 210640_s_at | -0.0088 | 0.9860 | |
| GSE20347 | GPER1 | 2852 | 210640_s_at | 0.1157 | 0.2862 | |
| GSE23400 | GPER1 | 2852 | 210640_s_at | -0.2466 | 0.0000 | |
| GSE26886 | GPER1 | 2852 | 210640_s_at | 0.6452 | 0.0014 | |
| GSE29001 | GPER1 | 2852 | 210640_s_at | 0.1913 | 0.4732 | |
| GSE38129 | GPER1 | 2852 | 210640_s_at | -0.4984 | 0.0180 | |
| GSE45670 | GPER1 | 2852 | 210640_s_at | -0.3393 | 0.0297 | |
| GSE53622 | GPER1 | 2852 | 101532 | -0.2739 | 0.0347 | |
| GSE53624 | GPER1 | 2852 | 75334 | -0.4491 | 0.0007 | |
| GSE63941 | GPER1 | 2852 | 210640_s_at | -0.9770 | 0.0246 | |
| GSE77861 | GPER1 | 2852 | 210640_s_at | -0.0926 | 0.5348 | |
| SRP064894 | GPER1 | 2852 | RNAseq | 0.4575 | 0.3047 | |
| SRP133303 | GPER1 | 2852 | RNAseq | -0.0473 | 0.7993 | |
| SRP159526 | GPER1 | 2852 | RNAseq | -0.9661 | 0.0387 | |
| SRP193095 | GPER1 | 2852 | RNAseq | 0.5037 | 0.0557 | |
| SRP219564 | GPER1 | 2852 | RNAseq | -0.1778 | 0.7699 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GPER1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of GPER1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPER1 | 2852 | 14 | 0 | 16 | |
| GSE20123 | GPER1 | 2852 | 14 | 0 | 16 | |
| GSE43470 | GPER1 | 2852 | 6 | 2 | 35 | |
| GSE46452 | GPER1 | 2852 | 13 | 1 | 45 | |
| GSE47630 | GPER1 | 2852 | 11 | 1 | 28 | |
| GSE54993 | GPER1 | 2852 | 0 | 7 | 63 | |
| GSE54994 | GPER1 | 2852 | 20 | 2 | 31 | |
| GSE60625 | GPER1 | 2852 | 0 | 0 | 11 | |
| GSE74703 | GPER1 | 2852 | 6 | 1 | 29 | |
| GSE74704 | GPER1 | 2852 | 9 | 0 | 11 |
Total number of gains: 93; Total number of losses: 14; Total Number of normals: 285.
Somatic mutations of GPER1:
Generating mutation plots.
Highly correlated genes for GPER1:
Showing top 20/219 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPER1 | PNCK | 0.678489 | 3 | 0 | 3 |
| GPER1 | GMPR | 0.65322 | 4 | 0 | 4 |
| GPER1 | COL5A3 | 0.638 | 3 | 0 | 3 |
| GPER1 | DIRAS2 | 0.630089 | 4 | 0 | 3 |
| GPER1 | CCL7 | 0.627491 | 3 | 0 | 3 |
| GPER1 | LRPAP1 | 0.619639 | 4 | 0 | 4 |
| GPER1 | LTBP2 | 0.615319 | 5 | 0 | 3 |
| GPER1 | BTBD17 | 0.61187 | 3 | 0 | 3 |
| GPER1 | WTIP | 0.611496 | 4 | 0 | 3 |
| GPER1 | KCNN3 | 0.607975 | 6 | 0 | 5 |
| GPER1 | CLEC11A | 0.6079 | 3 | 0 | 3 |
| GPER1 | NRP2 | 0.607697 | 4 | 0 | 4 |
| GPER1 | RASSF1 | 0.601834 | 4 | 0 | 3 |
| GPER1 | ARSI | 0.60139 | 3 | 0 | 3 |
| GPER1 | SHISA4 | 0.600227 | 3 | 0 | 3 |
| GPER1 | CKB | 0.59967 | 6 | 0 | 6 |
| GPER1 | APCDD1L | 0.599642 | 4 | 0 | 3 |
| GPER1 | SLC39A13 | 0.598361 | 3 | 0 | 3 |
| GPER1 | A1BG-AS1 | 0.594347 | 3 | 0 | 3 |
| GPER1 | USB1 | 0.594137 | 3 | 0 | 3 |
For details and further investigation, click here
