| Full name: spectrin beta, non-erythrocytic 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 6712 | HGNC ID: HGNC:11276 | Ensembl Gene: ENSG00000173898 | OMIM ID: 604985 |
| Drug and gene relationship at DGIdb | |||
Expression of SPTBN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPTBN2 | 6712 | 205155_s_at | -0.3178 | 0.5887 | |
| GSE20347 | SPTBN2 | 6712 | 205155_s_at | -0.8643 | 0.0000 | |
| GSE23400 | SPTBN2 | 6712 | 205155_s_at | -0.6396 | 0.0000 | |
| GSE26886 | SPTBN2 | 6712 | 205155_s_at | -0.0895 | 0.6051 | |
| GSE29001 | SPTBN2 | 6712 | 205155_s_at | -0.3728 | 0.0128 | |
| GSE38129 | SPTBN2 | 6712 | 205155_s_at | -0.7030 | 0.0026 | |
| GSE45670 | SPTBN2 | 6712 | 205155_s_at | -0.3142 | 0.0244 | |
| GSE53622 | SPTBN2 | 6712 | 98952 | -0.0879 | 0.4123 | |
| GSE53624 | SPTBN2 | 6712 | 98952 | -0.0165 | 0.8464 | |
| GSE63941 | SPTBN2 | 6712 | 205155_s_at | 0.7735 | 0.0835 | |
| GSE77861 | SPTBN2 | 6712 | 205155_s_at | -0.4994 | 0.0651 | |
| GSE97050 | SPTBN2 | 6712 | A_23_P98282 | 0.3695 | 0.5200 | |
| SRP007169 | SPTBN2 | 6712 | RNAseq | -0.6082 | 0.1586 | |
| SRP008496 | SPTBN2 | 6712 | RNAseq | -0.7115 | 0.0209 | |
| SRP064894 | SPTBN2 | 6712 | RNAseq | -1.5925 | 0.0000 | |
| SRP133303 | SPTBN2 | 6712 | RNAseq | -1.0436 | 0.0004 | |
| SRP159526 | SPTBN2 | 6712 | RNAseq | -1.0620 | 0.0023 | |
| SRP193095 | SPTBN2 | 6712 | RNAseq | -1.2655 | 0.0000 | |
| SRP219564 | SPTBN2 | 6712 | RNAseq | -0.9450 | 0.2530 | |
| TCGA | SPTBN2 | 6712 | RNAseq | 0.3230 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by SPTBN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPTBN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPTBN2 | 6712 | 9 | 3 | 18 | |
| GSE20123 | SPTBN2 | 6712 | 9 | 3 | 18 | |
| GSE43470 | SPTBN2 | 6712 | 6 | 1 | 36 | |
| GSE46452 | SPTBN2 | 6712 | 12 | 3 | 44 | |
| GSE47630 | SPTBN2 | 6712 | 9 | 4 | 27 | |
| GSE54993 | SPTBN2 | 6712 | 3 | 0 | 67 | |
| GSE54994 | SPTBN2 | 6712 | 10 | 4 | 39 | |
| GSE60625 | SPTBN2 | 6712 | 0 | 3 | 8 | |
| GSE74703 | SPTBN2 | 6712 | 4 | 0 | 32 | |
| GSE74704 | SPTBN2 | 6712 | 7 | 1 | 12 | |
| TCGA | SPTBN2 | 6712 | 26 | 7 | 63 |
Total number of gains: 95; Total number of losses: 29; Total Number of normals: 364.
Somatic mutations of SPTBN2:
Generating mutation plots.
Highly correlated genes for SPTBN2:
Showing top 20/1058 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPTBN2 | B3GNT8 | 0.726098 | 3 | 0 | 3 |
| SPTBN2 | RAB25 | 0.7236 | 8 | 0 | 8 |
| SPTBN2 | TMEM154 | 0.721196 | 4 | 0 | 4 |
| SPTBN2 | SLC35C1 | 0.716186 | 7 | 0 | 7 |
| SPTBN2 | TRIM29 | 0.712234 | 7 | 0 | 7 |
| SPTBN2 | MYEOV | 0.710481 | 4 | 0 | 4 |
| SPTBN2 | TSPO | 0.706792 | 6 | 0 | 6 |
| SPTBN2 | SPRYD4 | 0.702072 | 3 | 0 | 3 |
| SPTBN2 | TECR | 0.699708 | 8 | 0 | 8 |
| SPTBN2 | GIPC1 | 0.699088 | 8 | 0 | 7 |
| SPTBN2 | RARG | 0.697696 | 10 | 0 | 9 |
| SPTBN2 | TTC22 | 0.697459 | 9 | 0 | 8 |
| SPTBN2 | EVPL | 0.693147 | 10 | 0 | 8 |
| SPTBN2 | TPD52L1 | 0.691731 | 8 | 0 | 7 |
| SPTBN2 | BTBD11 | 0.691292 | 4 | 0 | 4 |
| SPTBN2 | EPS8L2 | 0.690604 | 8 | 0 | 7 |
| SPTBN2 | DUOXA1 | 0.689816 | 5 | 0 | 4 |
| SPTBN2 | PRSS3 | 0.689399 | 8 | 0 | 8 |
| SPTBN2 | BNIPL | 0.688636 | 4 | 0 | 4 |
| SPTBN2 | SYTL1 | 0.688457 | 5 | 0 | 5 |
For details and further investigation, click here
