| Full name: general transcription factor IIH subunit 1 | Alias Symbol: BTF2|P62|TFIIH | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 2965 | HGNC ID: HGNC:4655 | Ensembl Gene: ENSG00000110768 | OMIM ID: 189972 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GTF2H1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GTF2H1 | 2965 | 202451_at | 0.1736 | 0.5915 | |
| GSE20347 | GTF2H1 | 2965 | 202451_at | -0.3968 | 0.0053 | |
| GSE23400 | GTF2H1 | 2965 | 202451_at | 0.0551 | 0.4397 | |
| GSE26886 | GTF2H1 | 2965 | 202451_at | -0.0190 | 0.9356 | |
| GSE29001 | GTF2H1 | 2965 | 202451_at | 0.0543 | 0.8281 | |
| GSE38129 | GTF2H1 | 2965 | 202451_at | -0.2358 | 0.0730 | |
| GSE45670 | GTF2H1 | 2965 | 202451_at | 0.1083 | 0.5632 | |
| GSE53622 | GTF2H1 | 2965 | 37880 | 0.0087 | 0.9167 | |
| GSE53624 | GTF2H1 | 2965 | 37880 | -0.0845 | 0.0467 | |
| GSE63941 | GTF2H1 | 2965 | 202451_at | -0.6679 | 0.2435 | |
| GSE77861 | GTF2H1 | 2965 | 202451_at | 0.2651 | 0.4803 | |
| GSE97050 | GTF2H1 | 2965 | A_23_P36183 | 0.1409 | 0.5129 | |
| SRP007169 | GTF2H1 | 2965 | RNAseq | 0.9077 | 0.0244 | |
| SRP008496 | GTF2H1 | 2965 | RNAseq | 1.6304 | 0.0000 | |
| SRP064894 | GTF2H1 | 2965 | RNAseq | -0.1825 | 0.0876 | |
| SRP133303 | GTF2H1 | 2965 | RNAseq | 0.1187 | 0.5594 | |
| SRP159526 | GTF2H1 | 2965 | RNAseq | -0.4277 | 0.0685 | |
| SRP193095 | GTF2H1 | 2965 | RNAseq | -0.3209 | 0.0024 | |
| SRP219564 | GTF2H1 | 2965 | RNAseq | -0.4016 | 0.0992 | |
| TCGA | GTF2H1 | 2965 | RNAseq | 0.0285 | 0.5662 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GTF2H1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GTF2H1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GTF2H1 | 2965 | 0 | 10 | 20 | |
| GSE20123 | GTF2H1 | 2965 | 0 | 10 | 20 | |
| GSE43470 | GTF2H1 | 2965 | 1 | 5 | 37 | |
| GSE46452 | GTF2H1 | 2965 | 7 | 5 | 47 | |
| GSE47630 | GTF2H1 | 2965 | 3 | 10 | 27 | |
| GSE54993 | GTF2H1 | 2965 | 3 | 0 | 67 | |
| GSE54994 | GTF2H1 | 2965 | 2 | 13 | 38 | |
| GSE60625 | GTF2H1 | 2965 | 0 | 0 | 11 | |
| GSE74703 | GTF2H1 | 2965 | 1 | 3 | 32 | |
| GSE74704 | GTF2H1 | 2965 | 0 | 9 | 11 | |
| TCGA | GTF2H1 | 2965 | 11 | 29 | 56 |
Total number of gains: 28; Total number of losses: 94; Total Number of normals: 366.
Somatic mutations of GTF2H1:
Generating mutation plots.
Highly correlated genes for GTF2H1:
Showing top 20/200 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GTF2H1 | GBP1 | 0.713054 | 3 | 0 | 3 |
| GTF2H1 | GOSR2 | 0.708778 | 3 | 0 | 3 |
| GTF2H1 | STAMBPL1 | 0.703968 | 3 | 0 | 3 |
| GTF2H1 | RPAP3 | 0.693161 | 3 | 0 | 3 |
| GTF2H1 | MRPL14 | 0.692065 | 3 | 0 | 3 |
| GTF2H1 | RPL7L1 | 0.688408 | 3 | 0 | 3 |
| GTF2H1 | RPL22L1 | 0.681423 | 3 | 0 | 3 |
| GTF2H1 | PTPN23 | 0.674613 | 3 | 0 | 3 |
| GTF2H1 | PDCD2L | 0.674428 | 3 | 0 | 3 |
| GTF2H1 | TAP1 | 0.662465 | 4 | 0 | 3 |
| GTF2H1 | NVL | 0.661626 | 3 | 0 | 3 |
| GTF2H1 | INTS7 | 0.661592 | 4 | 0 | 4 |
| GTF2H1 | GLRX2 | 0.660509 | 3 | 0 | 3 |
| GTF2H1 | CHUK | 0.658609 | 4 | 0 | 4 |
| GTF2H1 | ZNF468 | 0.65717 | 3 | 0 | 3 |
| GTF2H1 | CBFA2T2 | 0.650748 | 3 | 0 | 3 |
| GTF2H1 | POGK | 0.647737 | 3 | 0 | 3 |
| GTF2H1 | SERPINB10 | 0.647574 | 3 | 0 | 3 |
| GTF2H1 | NEURL1B | 0.647435 | 3 | 0 | 3 |
| GTF2H1 | POLR3C | 0.645258 | 3 | 0 | 3 |
For details and further investigation, click here
