| Full name: lanosterol synthase | Alias Symbol: OSC | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 4047 | HGNC ID: HGNC:6708 | Ensembl Gene: ENSG00000160285 | OMIM ID: 600909 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LSS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LSS | 4047 | 202245_at | 0.1371 | 0.8271 | |
| GSE20347 | LSS | 4047 | 202245_at | -0.8043 | 0.0000 | |
| GSE23400 | LSS | 4047 | 202245_at | -0.4573 | 0.0000 | |
| GSE26886 | LSS | 4047 | 202245_at | -1.0714 | 0.0010 | |
| GSE29001 | LSS | 4047 | 202245_at | -0.4596 | 0.1017 | |
| GSE38129 | LSS | 4047 | 202245_at | -0.6586 | 0.0000 | |
| GSE45670 | LSS | 4047 | 202245_at | -0.3250 | 0.1034 | |
| GSE53622 | LSS | 4047 | 16157 | -0.6458 | 0.0000 | |
| GSE53624 | LSS | 4047 | 16157 | -0.4848 | 0.0000 | |
| GSE63941 | LSS | 4047 | 202245_at | -1.0303 | 0.1285 | |
| GSE77861 | LSS | 4047 | 202245_at | -0.8498 | 0.0297 | |
| GSE97050 | LSS | 4047 | A_24_P110799 | -0.4485 | 0.1606 | |
| SRP007169 | LSS | 4047 | RNAseq | -1.1348 | 0.0121 | |
| SRP008496 | LSS | 4047 | RNAseq | -1.0869 | 0.0000 | |
| SRP064894 | LSS | 4047 | RNAseq | -0.1427 | 0.4585 | |
| SRP133303 | LSS | 4047 | RNAseq | -0.7051 | 0.0004 | |
| SRP159526 | LSS | 4047 | RNAseq | -0.0890 | 0.8154 | |
| SRP193095 | LSS | 4047 | RNAseq | -0.1801 | 0.2302 | |
| SRP219564 | LSS | 4047 | RNAseq | -0.3864 | 0.1874 | |
| TCGA | LSS | 4047 | RNAseq | -0.1051 | 0.1091 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by LSS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LSS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LSS | 4047 | 3 | 9 | 18 | |
| GSE20123 | LSS | 4047 | 3 | 9 | 18 | |
| GSE43470 | LSS | 4047 | 0 | 14 | 29 | |
| GSE46452 | LSS | 4047 | 1 | 21 | 37 | |
| GSE47630 | LSS | 4047 | 6 | 17 | 17 | |
| GSE54993 | LSS | 4047 | 8 | 1 | 61 | |
| GSE54994 | LSS | 4047 | 5 | 8 | 40 | |
| GSE60625 | LSS | 4047 | 0 | 0 | 11 | |
| GSE74703 | LSS | 4047 | 0 | 10 | 26 | |
| GSE74704 | LSS | 4047 | 1 | 5 | 14 | |
| TCGA | LSS | 4047 | 10 | 38 | 48 |
Total number of gains: 37; Total number of losses: 132; Total Number of normals: 319.
Somatic mutations of LSS:
Generating mutation plots.
Highly correlated genes for LSS:
Showing top 20/855 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LSS | ZNF70 | 0.722326 | 3 | 0 | 3 |
| LSS | C6orf89 | 0.718717 | 3 | 0 | 3 |
| LSS | ZNF528 | 0.698749 | 3 | 0 | 3 |
| LSS | FBXO10 | 0.695224 | 3 | 0 | 3 |
| LSS | HELQ | 0.689561 | 4 | 0 | 3 |
| LSS | GNAT2 | 0.689439 | 3 | 0 | 3 |
| LSS | ZNF175 | 0.689091 | 3 | 0 | 3 |
| LSS | MTIF3 | 0.684897 | 3 | 0 | 3 |
| LSS | PCBD2 | 0.68155 | 3 | 0 | 3 |
| LSS | RHBDF1 | 0.673065 | 6 | 0 | 5 |
| LSS | RAB5A | 0.672712 | 9 | 0 | 8 |
| LSS | GBP6 | 0.671751 | 3 | 0 | 3 |
| LSS | RASA2 | 0.670003 | 3 | 0 | 3 |
| LSS | ANKS6 | 0.669155 | 4 | 0 | 3 |
| LSS | ABCG2 | 0.666897 | 4 | 0 | 4 |
| LSS | ACAA1 | 0.659303 | 9 | 0 | 8 |
| LSS | NPRL2 | 0.657114 | 5 | 0 | 4 |
| LSS | PDLIM2 | 0.655402 | 8 | 0 | 8 |
| LSS | RFFL | 0.654356 | 3 | 0 | 3 |
| LSS | GPD2 | 0.654308 | 4 | 0 | 4 |
For details and further investigation, click here
