| Full name: H6 family homeobox 2 | Alias Symbol: NKX5-2 | ||
| Type: protein-coding gene | Cytoband: 10q26.13 | ||
| Entrez ID: 3167 | HGNC ID: HGNC:5018 | Ensembl Gene: ENSG00000188816 | OMIM ID: 600647 |
| Drug and gene relationship at DGIdb | |||
Expression of HMX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMX2 | 3167 | 244565_at | 0.0117 | 0.9673 | |
| GSE26886 | HMX2 | 3167 | 244565_at | 0.3477 | 0.0075 | |
| GSE45670 | HMX2 | 3167 | 244565_at | 0.0430 | 0.6438 | |
| GSE53622 | HMX2 | 3167 | 94975 | 0.1150 | 0.2496 | |
| GSE53624 | HMX2 | 3167 | 94975 | 0.2558 | 0.0007 | |
| GSE63941 | HMX2 | 3167 | 244565_at | 0.3685 | 0.6388 | |
| GSE77861 | HMX2 | 3167 | 244565_at | -0.0666 | 0.5008 | |
| TCGA | HMX2 | 3167 | RNAseq | 0.7140 | 0.4098 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HMX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMX2 | 3167 | 1 | 6 | 23 | |
| GSE20123 | HMX2 | 3167 | 1 | 6 | 23 | |
| GSE43470 | HMX2 | 3167 | 0 | 9 | 34 | |
| GSE46452 | HMX2 | 3167 | 0 | 11 | 48 | |
| GSE47630 | HMX2 | 3167 | 2 | 14 | 24 | |
| GSE54993 | HMX2 | 3167 | 8 | 1 | 61 | |
| GSE54994 | HMX2 | 3167 | 1 | 9 | 43 | |
| GSE60625 | HMX2 | 3167 | 0 | 0 | 11 | |
| GSE74703 | HMX2 | 3167 | 0 | 6 | 30 | |
| GSE74704 | HMX2 | 3167 | 1 | 2 | 17 | |
| TCGA | HMX2 | 3167 | 4 | 27 | 65 |
Total number of gains: 18; Total number of losses: 91; Total Number of normals: 379.
Somatic mutations of HMX2:
Generating mutation plots.
Highly correlated genes for HMX2:
Showing top 20/43 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMX2 | CCDC151 | 0.736193 | 3 | 0 | 3 |
| HMX2 | CAND2 | 0.716838 | 3 | 0 | 3 |
| HMX2 | TESK1 | 0.711876 | 3 | 0 | 3 |
| HMX2 | CA10 | 0.647242 | 3 | 0 | 3 |
| HMX2 | C3orf22 | 0.637961 | 3 | 0 | 3 |
| HMX2 | COL8A2 | 0.631259 | 3 | 0 | 3 |
| HMX2 | CCDC149 | 0.630733 | 3 | 0 | 3 |
| HMX2 | SPATA3 | 0.6234 | 3 | 0 | 3 |
| HMX2 | ZNF576 | 0.622189 | 3 | 0 | 3 |
| HMX2 | CLDN9 | 0.619606 | 4 | 0 | 4 |
| HMX2 | GSC | 0.61888 | 4 | 0 | 4 |
| HMX2 | SYN2 | 0.610472 | 3 | 0 | 3 |
| HMX2 | PHOX2A | 0.59698 | 3 | 0 | 3 |
| HMX2 | SLC17A2 | 0.596264 | 3 | 0 | 3 |
| HMX2 | CCKBR | 0.5938 | 3 | 0 | 3 |
| HMX2 | UBA52 | 0.586722 | 3 | 0 | 3 |
| HMX2 | FAM181A | 0.584159 | 3 | 0 | 3 |
| HMX2 | SYNGAP1 | 0.583323 | 3 | 0 | 3 |
| HMX2 | SH2D2A | 0.581104 | 3 | 0 | 3 |
| HMX2 | NEUROG3 | 0.579034 | 3 | 0 | 3 |
For details and further investigation, click here
