| Full name: 4-hydroxyphenylpyruvate dioxygenase like | Alias Symbol: MGC15668|4-HPPD-L | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 84842 | HGNC ID: HGNC:28242 | Ensembl Gene: ENSG00000186603 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of HPDL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPDL | 84842 | 229332_at | 1.1561 | 0.2189 | |
| GSE26886 | HPDL | 84842 | 229332_at | 0.0235 | 0.9180 | |
| GSE45670 | HPDL | 84842 | 229332_at | 0.2612 | 0.3831 | |
| GSE53622 | HPDL | 84842 | 109690 | 0.7733 | 0.0000 | |
| GSE53624 | HPDL | 84842 | 109690 | 0.6943 | 0.0000 | |
| GSE63941 | HPDL | 84842 | 229332_at | 1.0241 | 0.2285 | |
| GSE77861 | HPDL | 84842 | 229332_at | -0.0509 | 0.8385 | |
| GSE97050 | HPDL | 84842 | A_23_P74449 | 0.4466 | 0.2144 | |
| SRP007169 | HPDL | 84842 | RNAseq | -0.0392 | 0.9531 | |
| SRP064894 | HPDL | 84842 | RNAseq | 0.3898 | 0.2193 | |
| SRP133303 | HPDL | 84842 | RNAseq | 0.0246 | 0.9474 | |
| SRP159526 | HPDL | 84842 | RNAseq | 1.5835 | 0.0198 | |
| SRP193095 | HPDL | 84842 | RNAseq | 0.7820 | 0.0133 | |
| SRP219564 | HPDL | 84842 | RNAseq | 1.6328 | 0.0920 | |
| TCGA | HPDL | 84842 | RNAseq | 0.7333 | 0.0015 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HPDL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPDL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPDL | 84842 | 4 | 3 | 23 | |
| GSE20123 | HPDL | 84842 | 4 | 2 | 24 | |
| GSE43470 | HPDL | 84842 | 7 | 2 | 34 | |
| GSE46452 | HPDL | 84842 | 2 | 1 | 56 | |
| GSE47630 | HPDL | 84842 | 9 | 3 | 28 | |
| GSE54993 | HPDL | 84842 | 0 | 1 | 69 | |
| GSE54994 | HPDL | 84842 | 13 | 2 | 38 | |
| GSE60625 | HPDL | 84842 | 0 | 0 | 11 | |
| GSE74703 | HPDL | 84842 | 6 | 1 | 29 | |
| GSE74704 | HPDL | 84842 | 2 | 0 | 18 | |
| TCGA | HPDL | 84842 | 11 | 16 | 69 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of HPDL:
Generating mutation plots.
Highly correlated genes for HPDL:
Showing top 20/89 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPDL | MANEAL | 0.694766 | 3 | 0 | 3 |
| HPDL | BMP8B | 0.690552 | 4 | 0 | 3 |
| HPDL | BAX | 0.680644 | 3 | 0 | 3 |
| HPDL | TMEM177 | 0.654532 | 3 | 0 | 3 |
| HPDL | PRR5 | 0.646228 | 3 | 0 | 3 |
| HPDL | UMODL1 | 0.643192 | 3 | 0 | 3 |
| HPDL | WDR74 | 0.642971 | 4 | 0 | 3 |
| HPDL | RANBP2 | 0.642577 | 3 | 0 | 3 |
| HPDL | USP27X | 0.628981 | 3 | 0 | 3 |
| HPDL | PLA2G15 | 0.626689 | 3 | 0 | 3 |
| HPDL | GNL1 | 0.624047 | 4 | 0 | 3 |
| HPDL | TMX1 | 0.623963 | 3 | 0 | 3 |
| HPDL | DNLZ | 0.619077 | 3 | 0 | 3 |
| HPDL | TTPAL | 0.618399 | 4 | 0 | 3 |
| HPDL | PRDM13 | 0.618341 | 4 | 0 | 3 |
| HPDL | TRMT10C | 0.618334 | 5 | 0 | 3 |
| HPDL | CPSF4 | 0.616983 | 4 | 0 | 3 |
| HPDL | POLQ | 0.614373 | 4 | 0 | 3 |
| HPDL | HECTD1 | 0.613777 | 3 | 0 | 3 |
| HPDL | ZIC1 | 0.6112 | 4 | 0 | 3 |
For details and further investigation, click here
