CPSF4

 

Full name: cleavage and polyadenylation specific factor 4 Alias Symbol: NAR|CPSF30
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 10898 HGNC ID: HGNC:2327 Ensembl Gene: ENSG00000160917 OMIM ID: 603052
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of CPSF4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CPSF4 10898 206688_s_at 0.3595 0.1347
GSE20347 CPSF4 10898 206688_s_at 0.3827 0.0010
GSE23400 CPSF4 10898 206688_s_at 0.2133 0.0004
GSE26886 CPSF4 10898 206688_s_at 0.0884 0.5760
GSE29001 CPSF4 10898 206688_s_at 0.2485 0.4815
GSE38129 CPSF4 10898 206688_s_at 0.3720 0.0000
GSE45670 CPSF4 10898 206688_s_at 0.3375 0.0650
GSE53622 CPSF4 10898 141865 0.5718 0.0000
GSE53624 CPSF4 10898 141865 0.5217 0.0000
GSE63941 CPSF4 10898 206688_s_at 0.6618 0.1475
GSE77861 CPSF4 10898 206688_s_at 0.1892 0.1365
GSE97050 CPSF4 10898 A_23_P42997 0.2897 0.3101
SRP007169 CPSF4 10898 RNAseq 0.2526 0.5723
SRP008496 CPSF4 10898 RNAseq 0.3937 0.2586
SRP064894 CPSF4 10898 RNAseq 0.3974 0.0246
SRP133303 CPSF4 10898 RNAseq 0.5208 0.0033
SRP159526 CPSF4 10898 RNAseq 0.2294 0.3952
SRP193095 CPSF4 10898 RNAseq 0.6147 0.0001
SRP219564 CPSF4 10898 RNAseq 0.4984 0.1232
TCGA CPSF4 10898 RNAseq 0.1702 0.0257

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CPSF4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CPSF4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CPSF4 10898 13 0 17
GSE20123 CPSF4 10898 13 0 17
GSE43470 CPSF4 10898 6 1 36
GSE46452 CPSF4 10898 11 1 47
GSE47630 CPSF4 10898 8 3 29
GSE54993 CPSF4 10898 1 9 60
GSE54994 CPSF4 10898 16 3 34
GSE60625 CPSF4 10898 0 0 11
GSE74703 CPSF4 10898 6 1 29
GSE74704 CPSF4 10898 9 0 11
TCGA CPSF4 10898 54 4 38

Total number of gains: 137; Total number of losses: 22; Total Number of normals: 329.  

 

Somatic mutations of CPSF4:

 

Generating mutation plots.

 

Highly correlated genes for CPSF4:

 

Showing top 20/649 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CPSF4PTCD10.754478303
CPSF4PODXL20.728635303
CPSF4POP70.7012411009
CPSF4LEMD20.694837403
CPSF4PPP1R350.692117606
CPSF4SLC12A90.68693310010
CPSF4MCM70.683671109
CPSF4DNAJC20.678902908
CPSF4ARL6IP10.669725404
CPSF4EPHB40.6685381009
CPSF4SLC45A30.667262303
CPSF4SRRT0.664886909
CPSF4TAF60.6608611009
CPSF4PUS70.66062412011
CPSF4ORAI10.657933303
CPSF4DNM10.655078303
CPSF4UBQLN40.654175303
CPSF4TFR20.651697505
CPSF4TRRAP0.6465251008
CPSF4CDK40.641963808

For details and further investigation, click here