| Full name: HtrA serine peptidase 4 | Alias Symbol: FLJ90724 | ||
| Type: protein-coding gene | Cytoband: 8p11.22 | ||
| Entrez ID: 203100 | HGNC ID: HGNC:26909 | Ensembl Gene: ENSG00000169495 | OMIM ID: 610700 |
| Drug and gene relationship at DGIdb | |||
Expression of HTRA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTRA4 | 203100 | 1553706_at | 0.4342 | 0.5391 | |
| GSE26886 | HTRA4 | 203100 | 1553706_at | 0.1777 | 0.0427 | |
| GSE45670 | HTRA4 | 203100 | 1553706_at | 0.1530 | 0.0836 | |
| GSE53622 | HTRA4 | 203100 | 50927 | 1.3146 | 0.0000 | |
| GSE53624 | HTRA4 | 203100 | 50927 | 1.1597 | 0.0000 | |
| GSE63941 | HTRA4 | 203100 | 1553706_at | -0.4227 | 0.0317 | |
| GSE77861 | HTRA4 | 203100 | 1553706_at | 0.0508 | 0.6077 | |
| GSE97050 | HTRA4 | 203100 | A_23_P44421 | 0.3296 | 0.3382 | |
| SRP007169 | HTRA4 | 203100 | RNAseq | 1.4461 | 0.0826 | |
| SRP064894 | HTRA4 | 203100 | RNAseq | 1.2432 | 0.0000 | |
| SRP133303 | HTRA4 | 203100 | RNAseq | 0.1423 | 0.2889 | |
| SRP159526 | HTRA4 | 203100 | RNAseq | 0.4487 | 0.2830 | |
| SRP193095 | HTRA4 | 203100 | RNAseq | 0.3393 | 0.0186 | |
| SRP219564 | HTRA4 | 203100 | RNAseq | 0.4269 | 0.1132 | |
| TCGA | HTRA4 | 203100 | RNAseq | 2.0397 | 0.0011 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by HTRA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTRA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTRA4 | 203100 | 10 | 4 | 16 | |
| GSE20123 | HTRA4 | 203100 | 10 | 4 | 16 | |
| GSE43470 | HTRA4 | 203100 | 8 | 6 | 29 | |
| GSE46452 | HTRA4 | 203100 | 20 | 5 | 34 | |
| GSE47630 | HTRA4 | 203100 | 12 | 7 | 21 | |
| GSE54993 | HTRA4 | 203100 | 2 | 16 | 52 | |
| GSE54994 | HTRA4 | 203100 | 16 | 7 | 30 | |
| GSE60625 | HTRA4 | 203100 | 3 | 0 | 8 | |
| GSE74703 | HTRA4 | 203100 | 8 | 5 | 23 | |
| GSE74704 | HTRA4 | 203100 | 9 | 1 | 10 | |
| TCGA | HTRA4 | 203100 | 35 | 23 | 38 |
Total number of gains: 133; Total number of losses: 78; Total Number of normals: 277.
Somatic mutations of HTRA4:
Generating mutation plots.
Highly correlated genes for HTRA4:
Showing top 20/79 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTRA4 | VASH2 | 0.74445 | 3 | 0 | 3 |
| HTRA4 | PLXNA3 | 0.730851 | 3 | 0 | 3 |
| HTRA4 | CPAMD8 | 0.718571 | 4 | 0 | 4 |
| HTRA4 | MEI1 | 0.711207 | 3 | 0 | 3 |
| HTRA4 | CD300LF | 0.700392 | 5 | 0 | 4 |
| HTRA4 | MPP3 | 0.682979 | 4 | 0 | 4 |
| HTRA4 | BATF2 | 0.681834 | 4 | 0 | 3 |
| HTRA4 | SH2D2A | 0.681011 | 3 | 0 | 3 |
| HTRA4 | MSR1 | 0.678247 | 3 | 0 | 3 |
| HTRA4 | SIGLEC10 | 0.678194 | 3 | 0 | 3 |
| HTRA4 | IRAK1 | 0.672092 | 3 | 0 | 3 |
| HTRA4 | SPRN | 0.664723 | 3 | 0 | 3 |
| HTRA4 | TTC21A | 0.663246 | 4 | 0 | 3 |
| HTRA4 | IL15RA | 0.662233 | 5 | 0 | 4 |
| HTRA4 | TRIM10 | 0.660679 | 3 | 0 | 3 |
| HTRA4 | HK3 | 0.660445 | 4 | 0 | 3 |
| HTRA4 | SEC62 | 0.654167 | 4 | 0 | 4 |
| HTRA4 | FBXO2 | 0.652878 | 3 | 0 | 3 |
| HTRA4 | TTC25 | 0.647492 | 3 | 0 | 3 |
| HTRA4 | ZMYND15 | 0.645441 | 6 | 0 | 4 |
For details and further investigation, click here
