| Full name: huntingtin | Alias Symbol: IT15 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 3064 | HGNC ID: HGNC:4851 | Ensembl Gene: ENSG00000197386 | OMIM ID: 613004 |
| Drug and gene relationship at DGIdb | |||
HTT involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05016 | Huntington's disease |
Expression of HTT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTT | 3064 | 202389_s_at | 0.7629 | 0.1004 | |
| GSE20347 | HTT | 3064 | 202389_s_at | -0.1384 | 0.1526 | |
| GSE23400 | HTT | 3064 | 202390_s_at | -0.1245 | 0.0005 | |
| GSE26886 | HTT | 3064 | 202389_s_at | 0.3724 | 0.0093 | |
| GSE29001 | HTT | 3064 | 202389_s_at | -0.1420 | 0.3961 | |
| GSE38129 | HTT | 3064 | 202390_s_at | -0.3645 | 0.0004 | |
| GSE45670 | HTT | 3064 | 202389_s_at | 0.1386 | 0.1087 | |
| GSE53622 | HTT | 3064 | 16128 | -0.5815 | 0.0000 | |
| GSE53624 | HTT | 3064 | 16128 | -0.3648 | 0.0000 | |
| GSE63941 | HTT | 3064 | 202389_s_at | -0.0693 | 0.8244 | |
| GSE77861 | HTT | 3064 | 202389_s_at | -0.0159 | 0.9446 | |
| GSE97050 | HTT | 3064 | A_23_P212749 | -0.3126 | 0.4284 | |
| SRP007169 | HTT | 3064 | RNAseq | 0.2770 | 0.5215 | |
| SRP008496 | HTT | 3064 | RNAseq | 0.1579 | 0.5813 | |
| SRP064894 | HTT | 3064 | RNAseq | 0.0026 | 0.9882 | |
| SRP133303 | HTT | 3064 | RNAseq | -0.2194 | 0.0934 | |
| SRP159526 | HTT | 3064 | RNAseq | -0.3692 | 0.1557 | |
| SRP193095 | HTT | 3064 | RNAseq | -0.1910 | 0.1057 | |
| SRP219564 | HTT | 3064 | RNAseq | -0.2298 | 0.3490 | |
| TCGA | HTT | 3064 | RNAseq | -0.1785 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HTT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTT | 3064 | 0 | 17 | 13 | |
| GSE20123 | HTT | 3064 | 0 | 17 | 13 | |
| GSE43470 | HTT | 3064 | 0 | 18 | 25 | |
| GSE46452 | HTT | 3064 | 1 | 36 | 22 | |
| GSE47630 | HTT | 3064 | 1 | 19 | 20 | |
| GSE54993 | HTT | 3064 | 10 | 0 | 60 | |
| GSE54994 | HTT | 3064 | 3 | 12 | 38 | |
| GSE60625 | HTT | 3064 | 0 | 0 | 11 | |
| GSE74703 | HTT | 3064 | 0 | 14 | 22 | |
| GSE74704 | HTT | 3064 | 0 | 9 | 11 | |
| TCGA | HTT | 3064 | 7 | 47 | 42 |
Total number of gains: 22; Total number of losses: 189; Total Number of normals: 277.
Somatic mutations of HTT:
Generating mutation plots.
Highly correlated genes for HTT:
Showing top 20/318 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTT | RAB1B | 0.742539 | 3 | 0 | 3 |
| HTT | ZNF771 | 0.740045 | 3 | 0 | 3 |
| HTT | GATAD2B | 0.724696 | 3 | 0 | 3 |
| HTT | MRPS6 | 0.712089 | 3 | 0 | 3 |
| HTT | ZNF284 | 0.70318 | 3 | 0 | 3 |
| HTT | LINGO1 | 0.701316 | 3 | 0 | 3 |
| HTT | ROMO1 | 0.693496 | 3 | 0 | 3 |
| HTT | ZNF518B | 0.684483 | 3 | 0 | 3 |
| HTT | CCM2 | 0.682224 | 3 | 0 | 3 |
| HTT | SDR39U1 | 0.681397 | 3 | 0 | 3 |
| HTT | GXYLT2 | 0.680878 | 3 | 0 | 3 |
| HTT | RICTOR | 0.67674 | 3 | 0 | 3 |
| HTT | RAB23 | 0.675994 | 3 | 0 | 3 |
| HTT | B3GALT6 | 0.673423 | 3 | 0 | 3 |
| HTT | C2orf88 | 0.66551 | 3 | 0 | 3 |
| HTT | TPSG1 | 0.659875 | 5 | 0 | 4 |
| HTT | TMEM129 | 0.657427 | 3 | 0 | 3 |
| HTT | CNTF | 0.656141 | 3 | 0 | 3 |
| HTT | NSMCE2 | 0.65514 | 3 | 0 | 3 |
| HTT | ZMYND19 | 0.654462 | 3 | 0 | 3 |
For details and further investigation, click here
