| Full name: isoleucyl-tRNA synthetase 2, mitochondrial | Alias Symbol: FLJ10326 | ||
| Type: protein-coding gene | Cytoband: 1q41 | ||
| Entrez ID: 55699 | HGNC ID: HGNC:29685 | Ensembl Gene: ENSG00000067704 | OMIM ID: 612801 |
| Drug and gene relationship at DGIdb | |||
Expression of IARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IARS2 | 55699 | 217900_at | 0.5520 | 0.1259 | |
| GSE20347 | IARS2 | 55699 | 217900_at | 0.1489 | 0.2797 | |
| GSE23400 | IARS2 | 55699 | 217900_at | 0.3531 | 0.0000 | |
| GSE26886 | IARS2 | 55699 | 217900_at | -0.1957 | 0.5183 | |
| GSE29001 | IARS2 | 55699 | 217900_at | 0.1881 | 0.5589 | |
| GSE38129 | IARS2 | 55699 | 217900_at | 0.2885 | 0.0064 | |
| GSE45670 | IARS2 | 55699 | 217900_at | 0.0277 | 0.8421 | |
| GSE53622 | IARS2 | 55699 | 79993 | 0.1212 | 0.0293 | |
| GSE53624 | IARS2 | 55699 | 79993 | 0.0968 | 0.1014 | |
| GSE63941 | IARS2 | 55699 | 217900_at | 0.1859 | 0.5922 | |
| GSE77861 | IARS2 | 55699 | 217900_at | 0.2086 | 0.1559 | |
| GSE97050 | IARS2 | 55699 | A_23_P74843 | 0.0180 | 0.9694 | |
| SRP007169 | IARS2 | 55699 | RNAseq | -0.5223 | 0.1435 | |
| SRP008496 | IARS2 | 55699 | RNAseq | -0.3966 | 0.1670 | |
| SRP064894 | IARS2 | 55699 | RNAseq | -0.0271 | 0.8865 | |
| SRP133303 | IARS2 | 55699 | RNAseq | 0.1054 | 0.3591 | |
| SRP159526 | IARS2 | 55699 | RNAseq | 0.2654 | 0.5385 | |
| SRP193095 | IARS2 | 55699 | RNAseq | -0.1342 | 0.1556 | |
| SRP219564 | IARS2 | 55699 | RNAseq | 0.0368 | 0.8844 | |
| TCGA | IARS2 | 55699 | RNAseq | 0.0817 | 0.0554 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IARS2 | 55699 | 9 | 0 | 21 | |
| GSE20123 | IARS2 | 55699 | 8 | 0 | 22 | |
| GSE43470 | IARS2 | 55699 | 8 | 1 | 34 | |
| GSE46452 | IARS2 | 55699 | 3 | 1 | 55 | |
| GSE47630 | IARS2 | 55699 | 15 | 0 | 25 | |
| GSE54993 | IARS2 | 55699 | 0 | 6 | 64 | |
| GSE54994 | IARS2 | 55699 | 15 | 0 | 38 | |
| GSE60625 | IARS2 | 55699 | 0 | 0 | 11 | |
| GSE74703 | IARS2 | 55699 | 8 | 1 | 27 | |
| GSE74704 | IARS2 | 55699 | 2 | 0 | 18 | |
| TCGA | IARS2 | 55699 | 46 | 3 | 47 |
Total number of gains: 114; Total number of losses: 12; Total Number of normals: 362.
Somatic mutations of IARS2:
Generating mutation plots.
Highly correlated genes for IARS2:
Showing top 20/815 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IARS2 | SS18L1 | 0.818842 | 3 | 0 | 3 |
| IARS2 | PPIP5K2 | 0.775862 | 3 | 0 | 3 |
| IARS2 | MMP15 | 0.728843 | 3 | 0 | 3 |
| IARS2 | AGGF1 | 0.712029 | 3 | 0 | 3 |
| IARS2 | CBFA2T2 | 0.711151 | 3 | 0 | 3 |
| IARS2 | PET117 | 0.705477 | 3 | 0 | 3 |
| IARS2 | PDE8A | 0.700057 | 4 | 0 | 4 |
| IARS2 | NIPBL | 0.700051 | 3 | 0 | 3 |
| IARS2 | UTP15 | 0.69582 | 3 | 0 | 3 |
| IARS2 | SRFBP1 | 0.693731 | 3 | 0 | 3 |
| IARS2 | MRI1 | 0.685085 | 3 | 0 | 3 |
| IARS2 | RLIM | 0.683869 | 3 | 0 | 3 |
| IARS2 | SEC11C | 0.681267 | 3 | 0 | 3 |
| IARS2 | TOP1MT | 0.680198 | 4 | 0 | 3 |
| IARS2 | HSD17B12 | 0.677916 | 3 | 0 | 3 |
| IARS2 | ALG1 | 0.67643 | 3 | 0 | 3 |
| IARS2 | ARF1 | 0.676389 | 3 | 0 | 3 |
| IARS2 | GEMIN5 | 0.674242 | 4 | 0 | 3 |
| IARS2 | IRF2BPL | 0.6738 | 3 | 0 | 3 |
| IARS2 | CFL1 | 0.669846 | 3 | 0 | 3 |
For details and further investigation, click here
