IDH3B

 

Full name: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta Alias Symbol: RP46
Type: protein-coding gene Cytoband: 20p13
Entrez ID: 3420 HGNC ID: HGNC:5385 Ensembl Gene: ENSG00000101365 OMIM ID: 604526
Drug and gene relationship at DGIdb

 

Expression of IDH3B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IDH3B 3420 210014_x_at -0.0000 1.0000
GSE20347 IDH3B 3420 210014_x_at 0.0245 0.8931
GSE23400 IDH3B 3420 210014_x_at 0.0590 0.3814
GSE26886 IDH3B 3420 210014_x_at -0.5776 0.0127
GSE29001 IDH3B 3420 210014_x_at -0.0186 0.9617
GSE38129 IDH3B 3420 210014_x_at 0.1333 0.3030
GSE45670 IDH3B 3420 210014_x_at 0.0518 0.8001
GSE53622 IDH3B 3420 96477 -0.0644 0.2558
GSE53624 IDH3B 3420 96477 -0.2406 0.0000
GSE63941 IDH3B 3420 210418_s_at 0.6288 0.0839
GSE77861 IDH3B 3420 210014_x_at 0.1166 0.6077
GSE97050 IDH3B 3420 A_33_P3261084 0.2635 0.5619
SRP007169 IDH3B 3420 RNAseq -0.9870 0.0048
SRP008496 IDH3B 3420 RNAseq -0.7151 0.0004
SRP064894 IDH3B 3420 RNAseq 0.2015 0.2996
SRP133303 IDH3B 3420 RNAseq 0.0809 0.4279
SRP159526 IDH3B 3420 RNAseq 0.1279 0.4729
SRP193095 IDH3B 3420 RNAseq -0.1328 0.2793
SRP219564 IDH3B 3420 RNAseq 0.1552 0.6424
TCGA IDH3B 3420 RNAseq -0.0004 0.9947

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IDH3B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IDH3B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IDH3B 3420 12 4 14
GSE20123 IDH3B 3420 13 4 13
GSE43470 IDH3B 3420 10 1 32
GSE46452 IDH3B 3420 26 1 32
GSE47630 IDH3B 3420 18 4 18
GSE54993 IDH3B 3420 2 14 54
GSE54994 IDH3B 3420 24 2 27
GSE60625 IDH3B 3420 0 0 11
GSE74703 IDH3B 3420 9 1 26
GSE74704 IDH3B 3420 8 1 11
TCGA IDH3B 3420 40 11 45

Total number of gains: 162; Total number of losses: 43; Total Number of normals: 283.  

 

Somatic mutations of IDH3B:

 

Generating mutation plots.

 

Highly correlated genes for IDH3B:

 

Showing top 20/77 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IDH3BSAMM500.721641404
IDH3BENO10.719073303
IDH3BATP6V1B20.666733303
IDH3BNDUFAF70.655865404
IDH3BUBE2D20.631054303
IDH3BCHTF80.616458303
IDH3BCIAPIN10.614075604
IDH3BSMAD5-AS10.606404303
IDH3BPTPRA0.603711604
IDH3BRALGAPB0.596049403
IDH3BCRLS10.59462403
IDH3BDHX380.591928503
IDH3BPOLR2C0.591047705
IDH3BRPL70.584609303
IDH3BMTUS10.580653303
IDH3BTMEM2300.576618604
IDH3BDDX280.574006403
IDH3BUQCRFS10.573063503
IDH3BECI20.571112404
IDH3BCFDP10.571504

For details and further investigation, click here