IFNAR2

 

Full name: interferon alpha and beta receptor subunit 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 21q22.11
Entrez ID: 3455 HGNC ID: HGNC:5433 Ensembl Gene: ENSG00000159110 OMIM ID: 602376
Drug and gene relationship at DGIdb

 

IFNAR2 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05160Hepatitis C
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection

 

Expression of IFNAR2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFNAR2 3455 204785_x_at 0.3803 0.3042
GSE20347 IFNAR2 3455 204786_s_at 0.6087 0.0005
GSE23400 IFNAR2 3455 204785_x_at 0.2066 0.0000
GSE26886 IFNAR2 3455 204785_x_at 0.5283 0.0259
GSE29001 IFNAR2 3455 204785_x_at 0.2358 0.1835
GSE38129 IFNAR2 3455 204785_x_at 0.2230 0.0808
GSE45670 IFNAR2 3455 204785_x_at 0.2495 0.0352
GSE53622 IFNAR2 3455 16354 0.3883 0.0000
GSE53624 IFNAR2 3455 16354 0.5746 0.0000
GSE63941 IFNAR2 3455 204785_x_at 0.2299 0.6494
GSE77861 IFNAR2 3455 204786_s_at 0.1477 0.3384
GSE97050 IFNAR2 3455 A_33_P3361457 0.7985 0.1330
SRP007169 IFNAR2 3455 RNAseq 0.7097 0.1513
SRP008496 IFNAR2 3455 RNAseq 0.1428 0.6957
SRP064894 IFNAR2 3455 RNAseq 0.7706 0.0000
SRP133303 IFNAR2 3455 RNAseq 0.4008 0.0133
SRP159526 IFNAR2 3455 RNAseq 0.3869 0.1980
SRP193095 IFNAR2 3455 RNAseq 0.4560 0.0072
SRP219564 IFNAR2 3455 RNAseq 0.3025 0.2587
TCGA IFNAR2 3455 RNAseq 0.0456 0.4840

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IFNAR2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFNAR2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFNAR2 3455 2 8 20
GSE20123 IFNAR2 3455 2 9 19
GSE43470 IFNAR2 3455 3 9 31
GSE46452 IFNAR2 3455 1 21 37
GSE47630 IFNAR2 3455 6 17 17
GSE54993 IFNAR2 3455 9 1 60
GSE54994 IFNAR2 3455 1 9 43
GSE60625 IFNAR2 3455 0 0 11
GSE74703 IFNAR2 3455 3 6 27
GSE74704 IFNAR2 3455 1 4 15
TCGA IFNAR2 3455 9 35 52

Total number of gains: 37; Total number of losses: 119; Total Number of normals: 332.  

 

Somatic mutations of IFNAR2:

 

Generating mutation plots.

 

Highly correlated genes for IFNAR2:

 

Showing top 20/671 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFNAR2CCNK0.733231303
IFNAR2PDIA50.726123303
IFNAR2PSMD130.689917303
IFNAR2AFAP1L20.68928303
IFNAR2C1orf350.683404303
IFNAR2PREX10.678271404
IFNAR2NPLOC40.675964403
IFNAR2LRRC8C0.67061303
IFNAR2LINC005970.666064303
IFNAR2VAV10.664259404
IFNAR2LMO10.660278303
IFNAR2EPSTI10.658778404
IFNAR2ZBED40.656705303
IFNAR2ICAM10.655037605
IFNAR2TBXAS10.653708303
IFNAR2SPI10.651561605
IFNAR2BATF30.651505706
IFNAR2PIK3AP10.651189504
IFNAR2TTC39C0.65089303
IFNAR2CTSZ0.648993504

For details and further investigation, click here