| Full name: interleukin 21 receptor | Alias Symbol: CD360 | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 50615 | HGNC ID: HGNC:6006 | Ensembl Gene: ENSG00000103522 | OMIM ID: 605383 |
| Drug and gene relationship at DGIdb | |||
IL21R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL21R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL21R | 50615 | 221658_s_at | 0.5189 | 0.4515 | |
| GSE20347 | IL21R | 50615 | 221658_s_at | -0.0638 | 0.4629 | |
| GSE23400 | IL21R | 50615 | 221658_s_at | -0.0107 | 0.8315 | |
| GSE26886 | IL21R | 50615 | 237753_at | -0.6217 | 0.1227 | |
| GSE29001 | IL21R | 50615 | 221658_s_at | 0.0539 | 0.8417 | |
| GSE38129 | IL21R | 50615 | 221658_s_at | 0.0433 | 0.8021 | |
| GSE45670 | IL21R | 50615 | 221658_s_at | 0.2323 | 0.0894 | |
| GSE53622 | IL21R | 50615 | 4561 | 0.6846 | 0.0000 | |
| GSE53624 | IL21R | 50615 | 4561 | 0.4454 | 0.0000 | |
| GSE63941 | IL21R | 50615 | 221658_s_at | -1.0009 | 0.0164 | |
| GSE77861 | IL21R | 50615 | 237753_at | -0.0913 | 0.2805 | |
| GSE97050 | IL21R | 50615 | A_24_P227927 | 1.2577 | 0.1894 | |
| SRP007169 | IL21R | 50615 | RNAseq | 1.0091 | 0.2015 | |
| SRP064894 | IL21R | 50615 | RNAseq | 0.9796 | 0.0000 | |
| SRP133303 | IL21R | 50615 | RNAseq | 0.7430 | 0.0002 | |
| SRP159526 | IL21R | 50615 | RNAseq | -0.1429 | 0.8095 | |
| SRP193095 | IL21R | 50615 | RNAseq | 0.3126 | 0.0608 | |
| SRP219564 | IL21R | 50615 | RNAseq | 0.9604 | 0.0146 | |
| TCGA | IL21R | 50615 | RNAseq | 0.9438 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by IL21R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL21R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL21R | 50615 | 3 | 5 | 22 | |
| GSE20123 | IL21R | 50615 | 3 | 4 | 23 | |
| GSE43470 | IL21R | 50615 | 4 | 3 | 36 | |
| GSE46452 | IL21R | 50615 | 38 | 1 | 20 | |
| GSE47630 | IL21R | 50615 | 11 | 7 | 22 | |
| GSE54993 | IL21R | 50615 | 3 | 5 | 62 | |
| GSE54994 | IL21R | 50615 | 4 | 9 | 40 | |
| GSE60625 | IL21R | 50615 | 4 | 0 | 7 | |
| GSE74703 | IL21R | 50615 | 4 | 2 | 30 | |
| GSE74704 | IL21R | 50615 | 2 | 2 | 16 | |
| TCGA | IL21R | 50615 | 19 | 12 | 65 |
Total number of gains: 95; Total number of losses: 50; Total Number of normals: 343.
Somatic mutations of IL21R:
Generating mutation plots.
Highly correlated genes for IL21R:
Showing top 20/249 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL21R | TMC8 | 0.77752 | 4 | 0 | 4 |
| IL21R | KLHL6 | 0.770699 | 4 | 0 | 4 |
| IL21R | TPST2 | 0.715709 | 3 | 0 | 3 |
| IL21R | ABI3 | 0.705912 | 6 | 0 | 5 |
| IL21R | CD3E | 0.676368 | 7 | 0 | 7 |
| IL21R | FAM78A | 0.674871 | 4 | 0 | 3 |
| IL21R | PTPN7 | 0.670744 | 8 | 0 | 7 |
| IL21R | PCED1B | 0.66509 | 4 | 0 | 3 |
| IL21R | EVI2A | 0.663635 | 6 | 0 | 5 |
| IL21R | SLA2 | 0.660675 | 5 | 0 | 5 |
| IL21R | MIR142 | 0.658072 | 3 | 0 | 3 |
| IL21R | TIGIT | 0.652213 | 7 | 0 | 5 |
| IL21R | TRAT1 | 0.650225 | 8 | 0 | 5 |
| IL21R | KLHDC7B | 0.64763 | 4 | 0 | 3 |
| IL21R | IL4I1 | 0.64523 | 6 | 0 | 4 |
| IL21R | CPNE5 | 0.642397 | 5 | 0 | 4 |
| IL21R | VAV1 | 0.641719 | 8 | 0 | 6 |
| IL21R | FBLL1 | 0.641316 | 3 | 0 | 3 |
| IL21R | LAIR1 | 0.639053 | 9 | 0 | 8 |
| IL21R | CD7 | 0.637121 | 7 | 0 | 5 |
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