| Full name: kelch like family member 6 | Alias Symbol: FLJ00029 | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 89857 | HGNC ID: HGNC:18653 | Ensembl Gene: ENSG00000172578 | OMIM ID: 614214 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL6 | 89857 | 228167_at | 0.4662 | 0.8100 | |
| GSE26886 | KLHL6 | 89857 | 1560397_s_at | -0.1216 | 0.2262 | |
| GSE45670 | KLHL6 | 89857 | 228167_at | -0.1258 | 0.7971 | |
| GSE53622 | KLHL6 | 89857 | 82151 | 0.6614 | 0.0000 | |
| GSE53624 | KLHL6 | 89857 | 82151 | 0.3955 | 0.0005 | |
| GSE63941 | KLHL6 | 89857 | 1560397_s_at | 0.2627 | 0.0845 | |
| GSE77861 | KLHL6 | 89857 | 1560397_s_at | 0.0628 | 0.5551 | |
| GSE97050 | KLHL6 | 89857 | A_23_P212655 | 0.9209 | 0.1450 | |
| SRP007169 | KLHL6 | 89857 | RNAseq | 3.1514 | 0.0001 | |
| SRP008496 | KLHL6 | 89857 | RNAseq | 2.2786 | 0.0003 | |
| SRP064894 | KLHL6 | 89857 | RNAseq | 1.3147 | 0.0002 | |
| SRP133303 | KLHL6 | 89857 | RNAseq | 0.6052 | 0.0036 | |
| SRP159526 | KLHL6 | 89857 | RNAseq | -0.2584 | 0.7728 | |
| SRP193095 | KLHL6 | 89857 | RNAseq | 0.3842 | 0.2684 | |
| SRP219564 | KLHL6 | 89857 | RNAseq | 1.5125 | 0.0073 | |
| TCGA | KLHL6 | 89857 | RNAseq | -0.0404 | 0.8006 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by KLHL6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL6 | 89857 | 25 | 0 | 5 | |
| GSE20123 | KLHL6 | 89857 | 25 | 0 | 5 | |
| GSE43470 | KLHL6 | 89857 | 24 | 0 | 19 | |
| GSE46452 | KLHL6 | 89857 | 19 | 1 | 39 | |
| GSE47630 | KLHL6 | 89857 | 27 | 2 | 11 | |
| GSE54993 | KLHL6 | 89857 | 1 | 19 | 50 | |
| GSE54994 | KLHL6 | 89857 | 40 | 0 | 13 | |
| GSE60625 | KLHL6 | 89857 | 0 | 6 | 5 | |
| GSE74703 | KLHL6 | 89857 | 20 | 0 | 16 | |
| GSE74704 | KLHL6 | 89857 | 17 | 0 | 3 | |
| TCGA | KLHL6 | 89857 | 77 | 0 | 19 |
Total number of gains: 275; Total number of losses: 28; Total Number of normals: 185.
Somatic mutations of KLHL6:
Generating mutation plots.
Highly correlated genes for KLHL6:
Showing top 20/204 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL6 | IL21R | 0.770699 | 4 | 0 | 4 |
| KLHL6 | ZC3H12D | 0.763326 | 3 | 0 | 3 |
| KLHL6 | P2RY8 | 0.743079 | 4 | 0 | 3 |
| KLHL6 | CD53 | 0.729072 | 4 | 0 | 4 |
| KLHL6 | MIR142 | 0.719057 | 3 | 0 | 3 |
| KLHL6 | ZBP1 | 0.715638 | 4 | 0 | 4 |
| KLHL6 | CYTIP | 0.712818 | 5 | 0 | 5 |
| KLHL6 | C16orf54 | 0.709102 | 3 | 0 | 3 |
| KLHL6 | TLR10 | 0.703056 | 3 | 0 | 3 |
| KLHL6 | MNDA | 0.701883 | 3 | 0 | 3 |
| KLHL6 | CD27 | 0.698091 | 5 | 0 | 4 |
| KLHL6 | STK17B | 0.697142 | 5 | 0 | 5 |
| KLHL6 | TRAT1 | 0.677774 | 4 | 0 | 4 |
| KLHL6 | RAC2 | 0.674069 | 5 | 0 | 4 |
| KLHL6 | XBP1 | 0.668963 | 3 | 0 | 3 |
| KLHL6 | RUNX2 | 0.666214 | 4 | 0 | 3 |
| KLHL6 | MFNG | 0.662167 | 4 | 0 | 3 |
| KLHL6 | CD5 | 0.657656 | 5 | 0 | 4 |
| KLHL6 | IL10RA | 0.654562 | 4 | 0 | 4 |
| KLHL6 | LCK | 0.654049 | 5 | 0 | 4 |
For details and further investigation, click here
