| Full name: interleukin 27 | Alias Symbol: IL-27|p28|IL27p28|IL-27A|IL27A|MGC71873 | ||
| Type: protein-coding gene | Cytoband: 16p12.1-p11.2 | ||
| Entrez ID: 246778 | HGNC ID: HGNC:19157 | Ensembl Gene: ENSG00000197272 | OMIM ID: 608273 |
| Drug and gene relationship at DGIdb | |||
Expression of IL27:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL27 | 246778 | 1552995_at | 0.0933 | 0.6830 | |
| GSE26886 | IL27 | 246778 | 1552995_at | -0.0139 | 0.9060 | |
| GSE45670 | IL27 | 246778 | 1552995_at | 0.1285 | 0.1620 | |
| GSE53622 | IL27 | 246778 | 65466 | 0.2343 | 0.0641 | |
| GSE53624 | IL27 | 246778 | 65466 | 0.2554 | 0.0788 | |
| GSE63941 | IL27 | 246778 | 1552995_at | 0.3264 | 0.0363 | |
| GSE77861 | IL27 | 246778 | 1552995_at | -0.0116 | 0.9430 | |
| TCGA | IL27 | 246778 | RNAseq | 1.5203 | 0.1085 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL27 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL27:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL27 | 246778 | 4 | 5 | 21 | |
| GSE20123 | IL27 | 246778 | 4 | 4 | 22 | |
| GSE43470 | IL27 | 246778 | 4 | 3 | 36 | |
| GSE46452 | IL27 | 246778 | 38 | 1 | 20 | |
| GSE47630 | IL27 | 246778 | 11 | 7 | 22 | |
| GSE54993 | IL27 | 246778 | 3 | 5 | 62 | |
| GSE54994 | IL27 | 246778 | 4 | 9 | 40 | |
| GSE60625 | IL27 | 246778 | 4 | 0 | 7 | |
| GSE74703 | IL27 | 246778 | 4 | 2 | 30 | |
| GSE74704 | IL27 | 246778 | 3 | 2 | 15 | |
| TCGA | IL27 | 246778 | 20 | 12 | 64 |
Total number of gains: 99; Total number of losses: 50; Total Number of normals: 339.
Somatic mutations of IL27:
Generating mutation plots.
Highly correlated genes for IL27:
Showing top 20/50 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL27 | GSX2 | 0.680554 | 3 | 0 | 3 |
| IL27 | KCNQ1 | 0.642235 | 3 | 0 | 3 |
| IL27 | ARRDC3-AS1 | 0.614384 | 4 | 0 | 4 |
| IL27 | OR8B8 | 0.612573 | 3 | 0 | 3 |
| IL27 | MUC13 | 0.612311 | 3 | 0 | 3 |
| IL27 | LILRA6 | 0.610411 | 3 | 0 | 3 |
| IL27 | KLK1 | 0.606832 | 3 | 0 | 3 |
| IL27 | CACNG4 | 0.605968 | 3 | 0 | 3 |
| IL27 | GBX1 | 0.604845 | 3 | 0 | 3 |
| IL27 | ICAM5 | 0.604564 | 3 | 0 | 3 |
| IL27 | C9orf131 | 0.59878 | 3 | 0 | 3 |
| IL27 | RPUSD1 | 0.597174 | 3 | 0 | 3 |
| IL27 | TMEM150B | 0.589641 | 3 | 0 | 3 |
| IL27 | MMP17 | 0.584179 | 4 | 0 | 3 |
| IL27 | AQP6 | 0.581675 | 4 | 0 | 3 |
| IL27 | C2orf81 | 0.58116 | 3 | 0 | 3 |
| IL27 | HCN1 | 0.578058 | 3 | 0 | 3 |
| IL27 | COX6B2 | 0.572601 | 3 | 0 | 3 |
| IL27 | LINC00598 | 0.571038 | 4 | 0 | 3 |
| IL27 | CXCR1 | 0.566096 | 4 | 0 | 3 |
For details and further investigation, click here
