| Full name: interleukin 4 | Alias Symbol: BSF1|IL-4|BCGF1|BCGF-1|MGC79402 | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 3565 | HGNC ID: HGNC:6014 | Ensembl Gene: ENSG00000113520 | OMIM ID: 147780 |
| Drug and gene relationship at DGIdb | |||
IL4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05140 | Leishmaniasis | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL4 | 3565 | 207538_at | -0.0315 | 0.9014 | |
| GSE20347 | IL4 | 3565 | 207539_s_at | 0.0064 | 0.9215 | |
| GSE23400 | IL4 | 3565 | 207539_s_at | -0.0158 | 0.5264 | |
| GSE26886 | IL4 | 3565 | 207538_at | 0.2417 | 0.0409 | |
| GSE29001 | IL4 | 3565 | 207538_at | -0.0653 | 0.5504 | |
| GSE38129 | IL4 | 3565 | 207538_at | -0.0363 | 0.4662 | |
| GSE45670 | IL4 | 3565 | 207538_at | -0.0094 | 0.9119 | |
| GSE53622 | IL4 | 3565 | 37552 | -0.3410 | 0.0081 | |
| GSE53624 | IL4 | 3565 | 37552 | -0.6080 | 0.0000 | |
| GSE63941 | IL4 | 3565 | 207538_at | 0.2857 | 0.0378 | |
| GSE77861 | IL4 | 3565 | 207539_s_at | -0.0835 | 0.4689 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL4 | 3565 | 1 | 11 | 18 | |
| GSE20123 | IL4 | 3565 | 2 | 11 | 17 | |
| GSE43470 | IL4 | 3565 | 2 | 9 | 32 | |
| GSE46452 | IL4 | 3565 | 0 | 27 | 32 | |
| GSE47630 | IL4 | 3565 | 0 | 21 | 19 | |
| GSE54993 | IL4 | 3565 | 9 | 1 | 60 | |
| GSE54994 | IL4 | 3565 | 2 | 14 | 37 | |
| GSE60625 | IL4 | 3565 | 0 | 0 | 11 | |
| GSE74703 | IL4 | 3565 | 2 | 6 | 28 | |
| GSE74704 | IL4 | 3565 | 1 | 5 | 14 | |
| TCGA | IL4 | 3565 | 3 | 39 | 54 |
Total number of gains: 22; Total number of losses: 144; Total Number of normals: 322.
Somatic mutations of IL4:
Generating mutation plots.
Highly correlated genes for IL4:
Showing top 20/274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL4 | RBP2 | 0.70667 | 3 | 0 | 3 |
| IL4 | FAM53A | 0.669174 | 3 | 0 | 3 |
| IL4 | CNKSR2 | 0.659384 | 5 | 0 | 4 |
| IL4 | ODF3L1 | 0.650913 | 4 | 0 | 3 |
| IL4 | STXBP6 | 0.632655 | 3 | 0 | 3 |
| IL4 | ATF7 | 0.631121 | 4 | 0 | 3 |
| IL4 | SCGN | 0.614062 | 5 | 0 | 5 |
| IL4 | KCNG1 | 0.613478 | 3 | 0 | 3 |
| IL4 | IL1RL1 | 0.613137 | 4 | 0 | 3 |
| IL4 | PHF21B | 0.612345 | 3 | 0 | 3 |
| IL4 | PAPOLB | 0.608622 | 4 | 0 | 3 |
| IL4 | ESRRG | 0.60775 | 3 | 0 | 3 |
| IL4 | HEXIM2 | 0.607135 | 3 | 0 | 3 |
| IL4 | CKMT2 | 0.605073 | 3 | 0 | 3 |
| IL4 | BTBD17 | 0.603793 | 5 | 0 | 4 |
| IL4 | ACY1 | 0.598736 | 4 | 0 | 3 |
| IL4 | GRM6 | 0.598074 | 5 | 0 | 4 |
| IL4 | LINC00474 | 0.592556 | 7 | 0 | 5 |
| IL4 | CST5 | 0.587476 | 6 | 0 | 5 |
| IL4 | ANKRD18A | 0.587423 | 3 | 0 | 3 |
For details and further investigation, click here
