| Full name: Kruppel like factor 4 | Alias Symbol: EZF|GKLF | ||
| Type: protein-coding gene | Cytoband: 9q31.2 | ||
| Entrez ID: 9314 | HGNC ID: HGNC:6348 | Ensembl Gene: ENSG00000136826 | OMIM ID: 602253 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
KLF4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of KLF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLF4 | 9314 | 221841_s_at | -1.3633 | 0.0357 | |
| GSE20347 | KLF4 | 9314 | 221841_s_at | -1.9534 | 0.0000 | |
| GSE23400 | KLF4 | 9314 | 221841_s_at | -1.3563 | 0.0000 | |
| GSE26886 | KLF4 | 9314 | 221841_s_at | -1.8108 | 0.0001 | |
| GSE29001 | KLF4 | 9314 | 221841_s_at | -1.5069 | 0.0004 | |
| GSE38129 | KLF4 | 9314 | 221841_s_at | -1.7964 | 0.0000 | |
| GSE45670 | KLF4 | 9314 | 221841_s_at | -0.7190 | 0.0018 | |
| GSE53622 | KLF4 | 9314 | 64574 | -1.5215 | 0.0000 | |
| GSE53624 | KLF4 | 9314 | 64574 | -1.7772 | 0.0000 | |
| GSE63941 | KLF4 | 9314 | 221841_s_at | 0.5022 | 0.6535 | |
| GSE77861 | KLF4 | 9314 | 221841_s_at | -0.3087 | 0.2412 | |
| GSE97050 | KLF4 | 9314 | A_23_P32233 | -0.9837 | 0.1186 | |
| SRP007169 | KLF4 | 9314 | RNAseq | -2.0170 | 0.0000 | |
| SRP008496 | KLF4 | 9314 | RNAseq | -2.2454 | 0.0000 | |
| SRP064894 | KLF4 | 9314 | RNAseq | -1.6864 | 0.0000 | |
| SRP133303 | KLF4 | 9314 | RNAseq | -1.2795 | 0.0018 | |
| SRP159526 | KLF4 | 9314 | RNAseq | -1.8457 | 0.0004 | |
| SRP193095 | KLF4 | 9314 | RNAseq | -0.8466 | 0.0003 | |
| SRP219564 | KLF4 | 9314 | RNAseq | -1.1865 | 0.0071 | |
| TCGA | KLF4 | 9314 | RNAseq | -0.2472 | 0.0208 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by KLF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLF4 | 9314 | 4 | 9 | 17 | |
| GSE20123 | KLF4 | 9314 | 5 | 8 | 17 | |
| GSE43470 | KLF4 | 9314 | 7 | 3 | 33 | |
| GSE46452 | KLF4 | 9314 | 6 | 13 | 40 | |
| GSE47630 | KLF4 | 9314 | 3 | 16 | 21 | |
| GSE54993 | KLF4 | 9314 | 3 | 3 | 64 | |
| GSE54994 | KLF4 | 9314 | 9 | 10 | 34 | |
| GSE60625 | KLF4 | 9314 | 0 | 0 | 11 | |
| GSE74703 | KLF4 | 9314 | 6 | 3 | 27 | |
| GSE74704 | KLF4 | 9314 | 2 | 6 | 12 | |
| TCGA | KLF4 | 9314 | 26 | 21 | 49 |
Total number of gains: 71; Total number of losses: 92; Total Number of normals: 325.
Somatic mutations of KLF4:
Generating mutation plots.
Highly correlated genes for KLF4:
Showing top 20/1195 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLF4 | RNLS | 0.778896 | 4 | 0 | 4 |
| KLF4 | HDHD2 | 0.742656 | 4 | 0 | 4 |
| KLF4 | EMP1 | 0.738231 | 11 | 0 | 11 |
| KLF4 | AP3M1 | 0.735832 | 3 | 0 | 3 |
| KLF4 | AMOTL1 | 0.729402 | 3 | 0 | 3 |
| KLF4 | KANK1 | 0.727177 | 12 | 0 | 10 |
| KLF4 | INSRR | 0.72693 | 3 | 0 | 3 |
| KLF4 | ATF7 | 0.726112 | 3 | 0 | 3 |
| KLF4 | PIGB | 0.717019 | 3 | 0 | 3 |
| KLF4 | CTDSP1 | 0.716013 | 3 | 0 | 3 |
| KLF4 | RNPC3 | 0.715632 | 3 | 0 | 3 |
| KLF4 | PXMP2 | 0.711703 | 3 | 0 | 3 |
| KLF4 | IMPACT | 0.708636 | 3 | 0 | 3 |
| KLF4 | C5orf66-AS1 | 0.708422 | 6 | 0 | 6 |
| KLF4 | MAML2 | 0.707449 | 3 | 0 | 3 |
| KLF4 | ID4 | 0.706443 | 9 | 0 | 8 |
| KLF4 | MACROD2 | 0.705838 | 3 | 0 | 3 |
| KLF4 | PEX19 | 0.705131 | 3 | 0 | 3 |
| KLF4 | GPD1L | 0.704894 | 11 | 0 | 10 |
| KLF4 | MAL | 0.701518 | 10 | 0 | 9 |
For details and further investigation, click here
