| Full name: integrator complex subunit 5 | Alias Symbol: INT5 | ||
| Type: protein-coding gene | Cytoband: 11q12.3 | ||
| Entrez ID: 80789 | HGNC ID: HGNC:29352 | Ensembl Gene: ENSG00000185085 | OMIM ID: 611349 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of INTS5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INTS5 | 80789 | 53968_at | 0.2156 | 0.6457 | |
| GSE20347 | INTS5 | 80789 | 53968_at | 0.1004 | 0.4979 | |
| GSE23400 | INTS5 | 80789 | 53968_at | 0.2258 | 0.0008 | |
| GSE26886 | INTS5 | 80789 | 53968_at | 0.4313 | 0.0014 | |
| GSE29001 | INTS5 | 80789 | 53968_at | -0.0969 | 0.8016 | |
| GSE38129 | INTS5 | 80789 | 53968_at | 0.2370 | 0.0749 | |
| GSE45670 | INTS5 | 80789 | 53968_at | 0.2836 | 0.0019 | |
| GSE53622 | INTS5 | 80789 | 64706 | -0.0296 | 0.7261 | |
| GSE53624 | INTS5 | 80789 | 64706 | -0.3502 | 0.0000 | |
| GSE63941 | INTS5 | 80789 | 53968_at | -0.0722 | 0.8956 | |
| GSE77861 | INTS5 | 80789 | 221818_at | 0.2234 | 0.0532 | |
| GSE97050 | INTS5 | 80789 | A_23_P13338 | 0.0964 | 0.8185 | |
| SRP007169 | INTS5 | 80789 | RNAseq | -0.2220 | 0.5548 | |
| SRP008496 | INTS5 | 80789 | RNAseq | -0.5056 | 0.0106 | |
| SRP064894 | INTS5 | 80789 | RNAseq | -0.0225 | 0.8882 | |
| SRP133303 | INTS5 | 80789 | RNAseq | -0.0332 | 0.8501 | |
| SRP159526 | INTS5 | 80789 | RNAseq | 0.0085 | 0.9589 | |
| SRP193095 | INTS5 | 80789 | RNAseq | 0.1046 | 0.3429 | |
| SRP219564 | INTS5 | 80789 | RNAseq | -0.0631 | 0.8399 | |
| TCGA | INTS5 | 80789 | RNAseq | 0.0061 | 0.9055 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by INTS5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INTS5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INTS5 | 80789 | 6 | 5 | 19 | |
| GSE20123 | INTS5 | 80789 | 6 | 5 | 19 | |
| GSE43470 | INTS5 | 80789 | 1 | 6 | 36 | |
| GSE46452 | INTS5 | 80789 | 8 | 4 | 47 | |
| GSE47630 | INTS5 | 80789 | 3 | 7 | 30 | |
| GSE54993 | INTS5 | 80789 | 3 | 0 | 67 | |
| GSE54994 | INTS5 | 80789 | 4 | 5 | 44 | |
| GSE60625 | INTS5 | 80789 | 0 | 3 | 8 | |
| GSE74703 | INTS5 | 80789 | 1 | 3 | 32 | |
| GSE74704 | INTS5 | 80789 | 4 | 3 | 13 | |
| TCGA | INTS5 | 80789 | 14 | 11 | 71 |
Total number of gains: 50; Total number of losses: 52; Total Number of normals: 386.
Somatic mutations of INTS5:
Generating mutation plots.
Highly correlated genes for INTS5:
Showing top 20/338 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INTS5 | LONP1 | 0.749387 | 3 | 0 | 3 |
| INTS5 | TOR2A | 0.692976 | 3 | 0 | 3 |
| INTS5 | BMF | 0.689109 | 3 | 0 | 3 |
| INTS5 | PPP1CA | 0.684377 | 6 | 0 | 5 |
| INTS5 | HIP1R | 0.678068 | 5 | 0 | 5 |
| INTS5 | RFT1 | 0.676683 | 3 | 0 | 3 |
| INTS5 | PRPF19 | 0.674946 | 10 | 0 | 9 |
| INTS5 | TMEM223 | 0.667309 | 8 | 0 | 7 |
| INTS5 | MIIP | 0.661769 | 3 | 0 | 3 |
| INTS5 | E2F7 | 0.658606 | 3 | 0 | 3 |
| INTS5 | MIB2 | 0.653834 | 4 | 0 | 3 |
| INTS5 | LRFN3 | 0.649666 | 3 | 0 | 3 |
| INTS5 | ZWINT | 0.641553 | 5 | 0 | 5 |
| INTS5 | RELB | 0.639606 | 5 | 0 | 4 |
| INTS5 | FAM189B | 0.639271 | 5 | 0 | 4 |
| INTS5 | C7orf26 | 0.637502 | 3 | 0 | 3 |
| INTS5 | ENGASE | 0.637017 | 3 | 0 | 3 |
| INTS5 | NUDT22 | 0.630632 | 7 | 0 | 6 |
| INTS5 | YDJC | 0.630214 | 4 | 0 | 3 |
| INTS5 | SKA3 | 0.627235 | 3 | 0 | 3 |
For details and further investigation, click here
