| Full name: GLI family zinc finger 3 | Alias Symbol: PAP-A|PAPA|PAPA1|PAPB|ACLS|PPDIV | ||
| Type: protein-coding gene | Cytoband: 7p14.1 | ||
| Entrez ID: 2737 | HGNC ID: HGNC:4319 | Ensembl Gene: ENSG00000106571 | OMIM ID: 165240 |
| Drug and gene relationship at DGIdb | |||
GLI3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04340 | Hedgehog signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05217 | Basal cell carcinoma |
Expression of GLI3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLI3 | 2737 | 227376_at | 0.6830 | 0.2055 | |
| GSE20347 | GLI3 | 2737 | 205201_at | 0.2227 | 0.1201 | |
| GSE23400 | GLI3 | 2737 | 205201_at | 0.1702 | 0.0014 | |
| GSE26886 | GLI3 | 2737 | 227376_at | 1.9669 | 0.0000 | |
| GSE29001 | GLI3 | 2737 | 205201_at | 0.1063 | 0.6644 | |
| GSE38129 | GLI3 | 2737 | 205201_at | 0.0569 | 0.6773 | |
| GSE45670 | GLI3 | 2737 | 205201_at | 0.0019 | 0.9950 | |
| GSE53622 | GLI3 | 2737 | 25923 | 0.5153 | 0.0001 | |
| GSE53624 | GLI3 | 2737 | 25923 | 0.6543 | 0.0000 | |
| GSE63941 | GLI3 | 2737 | 205201_at | -1.2366 | 0.0015 | |
| GSE77861 | GLI3 | 2737 | 205201_at | 0.1558 | 0.3194 | |
| GSE97050 | GLI3 | 2737 | A_33_P3290562 | -0.0303 | 0.9340 | |
| SRP007169 | GLI3 | 2737 | RNAseq | 2.3471 | 0.0001 | |
| SRP008496 | GLI3 | 2737 | RNAseq | 2.9121 | 0.0000 | |
| SRP064894 | GLI3 | 2737 | RNAseq | 0.7286 | 0.0017 | |
| SRP133303 | GLI3 | 2737 | RNAseq | 0.7945 | 0.0006 | |
| SRP159526 | GLI3 | 2737 | RNAseq | -0.2044 | 0.6560 | |
| SRP193095 | GLI3 | 2737 | RNAseq | 1.2533 | 0.0000 | |
| SRP219564 | GLI3 | 2737 | RNAseq | 0.6690 | 0.1420 | |
| TCGA | GLI3 | 2737 | RNAseq | 0.3764 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by GLI3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GLI3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLI3 | 2737 | 14 | 0 | 16 | |
| GSE20123 | GLI3 | 2737 | 13 | 0 | 17 | |
| GSE43470 | GLI3 | 2737 | 4 | 0 | 39 | |
| GSE46452 | GLI3 | 2737 | 11 | 1 | 47 | |
| GSE47630 | GLI3 | 2737 | 8 | 1 | 31 | |
| GSE54993 | GLI3 | 2737 | 0 | 8 | 62 | |
| GSE54994 | GLI3 | 2737 | 18 | 3 | 32 | |
| GSE60625 | GLI3 | 2737 | 0 | 0 | 11 | |
| GSE74703 | GLI3 | 2737 | 4 | 0 | 32 | |
| GSE74704 | GLI3 | 2737 | 7 | 0 | 13 | |
| TCGA | GLI3 | 2737 | 53 | 8 | 35 |
Total number of gains: 132; Total number of losses: 21; Total Number of normals: 335.
Somatic mutations of GLI3:
Generating mutation plots.
Highly correlated genes for GLI3:
Showing top 20/779 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLI3 | CBL | 0.811636 | 3 | 0 | 3 |
| GLI3 | LRRC23 | 0.799347 | 3 | 0 | 3 |
| GLI3 | ZZEF1 | 0.7827 | 3 | 0 | 3 |
| GLI3 | RILPL2 | 0.772713 | 3 | 0 | 3 |
| GLI3 | TAOK1 | 0.770707 | 3 | 0 | 3 |
| GLI3 | PHRF1 | 0.767362 | 3 | 0 | 3 |
| GLI3 | TBC1D5 | 0.764153 | 3 | 0 | 3 |
| GLI3 | DHX37 | 0.757283 | 3 | 0 | 3 |
| GLI3 | MAK16 | 0.753909 | 3 | 0 | 3 |
| GLI3 | KLHL13 | 0.751577 | 3 | 0 | 3 |
| GLI3 | PHIP | 0.749726 | 3 | 0 | 3 |
| GLI3 | IRF2BP2 | 0.744381 | 3 | 0 | 3 |
| GLI3 | HEATR6 | 0.743728 | 4 | 0 | 4 |
| GLI3 | ZCCHC3 | 0.742813 | 3 | 0 | 3 |
| GLI3 | DGKH | 0.736393 | 4 | 0 | 4 |
| GLI3 | ITFG1 | 0.736001 | 3 | 0 | 3 |
| GLI3 | CSNK2A2 | 0.735248 | 4 | 0 | 4 |
| GLI3 | PTPRD | 0.729422 | 3 | 0 | 3 |
| GLI3 | SLCO3A1 | 0.729286 | 3 | 0 | 3 |
| GLI3 | AP3D1 | 0.728175 | 3 | 0 | 3 |
For details and further investigation, click here
