| Full name: MLLT3 super elongation complex subunit | Alias Symbol: AF-9|AF9|YEATS3 | ||
| Type: protein-coding gene | Cytoband: 9p21.3 | ||
| Entrez ID: 4300 | HGNC ID: HGNC:7136 | Ensembl Gene: ENSG00000171843 | OMIM ID: 159558 |
| Drug and gene relationship at DGIdb | |||
Expression of MLLT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLLT3 | 4300 | 204917_s_at | -0.6725 | 0.3354 | |
| GSE20347 | MLLT3 | 4300 | 204917_s_at | -0.1161 | 0.5346 | |
| GSE23400 | MLLT3 | 4300 | 204917_s_at | -0.0411 | 0.3829 | |
| GSE26886 | MLLT3 | 4300 | 204917_s_at | 0.2838 | 0.4264 | |
| GSE29001 | MLLT3 | 4300 | 204917_s_at | -0.1030 | 0.6611 | |
| GSE38129 | MLLT3 | 4300 | 204917_s_at | -0.2606 | 0.0629 | |
| GSE45670 | MLLT3 | 4300 | 204917_s_at | -0.6308 | 0.0068 | |
| GSE53622 | MLLT3 | 4300 | 33217 | -0.3437 | 0.0055 | |
| GSE53624 | MLLT3 | 4300 | 33217 | -0.2721 | 0.0103 | |
| GSE63941 | MLLT3 | 4300 | 204917_s_at | -0.9228 | 0.2556 | |
| GSE77861 | MLLT3 | 4300 | 204917_s_at | -0.1836 | 0.1727 | |
| GSE97050 | MLLT3 | 4300 | A_23_P216693 | -0.3194 | 0.2269 | |
| SRP007169 | MLLT3 | 4300 | RNAseq | 0.4251 | 0.3988 | |
| SRP008496 | MLLT3 | 4300 | RNAseq | 0.4526 | 0.1238 | |
| SRP064894 | MLLT3 | 4300 | RNAseq | -0.3368 | 0.0666 | |
| SRP133303 | MLLT3 | 4300 | RNAseq | -0.0758 | 0.6883 | |
| SRP159526 | MLLT3 | 4300 | RNAseq | -0.4804 | 0.0683 | |
| SRP193095 | MLLT3 | 4300 | RNAseq | -0.4661 | 0.0805 | |
| SRP219564 | MLLT3 | 4300 | RNAseq | -0.5623 | 0.1573 | |
| TCGA | MLLT3 | 4300 | RNAseq | -0.3907 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MLLT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLLT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLLT3 | 4300 | 2 | 16 | 12 | |
| GSE20123 | MLLT3 | 4300 | 2 | 16 | 12 | |
| GSE43470 | MLLT3 | 4300 | 4 | 12 | 27 | |
| GSE46452 | MLLT3 | 4300 | 2 | 23 | 34 | |
| GSE47630 | MLLT3 | 4300 | 3 | 27 | 10 | |
| GSE54993 | MLLT3 | 4300 | 7 | 2 | 61 | |
| GSE54994 | MLLT3 | 4300 | 8 | 16 | 29 | |
| GSE60625 | MLLT3 | 4300 | 0 | 0 | 11 | |
| GSE74703 | MLLT3 | 4300 | 4 | 9 | 23 | |
| GSE74704 | MLLT3 | 4300 | 0 | 13 | 7 | |
| TCGA | MLLT3 | 4300 | 12 | 51 | 33 |
Total number of gains: 44; Total number of losses: 185; Total Number of normals: 259.
Somatic mutations of MLLT3:
Generating mutation plots.
Highly correlated genes for MLLT3:
Showing top 20/346 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLLT3 | HDHD2 | 0.781639 | 3 | 0 | 3 |
| MLLT3 | GSTT1 | 0.777524 | 3 | 0 | 3 |
| MLLT3 | PCMTD1 | 0.776566 | 3 | 0 | 3 |
| MLLT3 | MACROD2 | 0.741751 | 4 | 0 | 3 |
| MLLT3 | FAR2 | 0.740479 | 3 | 0 | 3 |
| MLLT3 | CLSTN2 | 0.735885 | 3 | 0 | 3 |
| MLLT3 | ADH1B | 0.730167 | 3 | 0 | 3 |
| MLLT3 | VAMP1 | 0.723749 | 3 | 0 | 3 |
| MLLT3 | STK38L | 0.720338 | 3 | 0 | 3 |
| MLLT3 | CLOCK | 0.717092 | 3 | 0 | 3 |
| MLLT3 | CNOT1 | 0.714906 | 3 | 0 | 3 |
| MLLT3 | ZFR | 0.713194 | 4 | 0 | 3 |
| MLLT3 | IPO8 | 0.706771 | 3 | 0 | 3 |
| MLLT3 | ZMYM4 | 0.703278 | 4 | 0 | 4 |
| MLLT3 | DYM | 0.703163 | 4 | 0 | 3 |
| MLLT3 | TLE2 | 0.701482 | 4 | 0 | 3 |
| MLLT3 | C12orf29 | 0.70148 | 3 | 0 | 3 |
| MLLT3 | CNN1 | 0.701083 | 3 | 0 | 3 |
| MLLT3 | LPIN2 | 0.697635 | 3 | 0 | 3 |
| MLLT3 | TXNL4A | 0.688524 | 3 | 0 | 3 |
For details and further investigation, click here
