| Full name: IQ motif containing GTPase activating protein 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q13.3 | ||
| Entrez ID: 10788 | HGNC ID: HGNC:6111 | Ensembl Gene: ENSG00000145703 | OMIM ID: 605401 |
| Drug and gene relationship at DGIdb | |||
IQGAP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of IQGAP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IQGAP2 | 10788 | 203474_at | -0.2255 | 0.9028 | |
| GSE20347 | IQGAP2 | 10788 | 203474_at | 0.0937 | 0.7068 | |
| GSE23400 | IQGAP2 | 10788 | 203474_at | -0.0370 | 0.6071 | |
| GSE26886 | IQGAP2 | 10788 | 203474_at | 0.7366 | 0.0430 | |
| GSE29001 | IQGAP2 | 10788 | 203474_at | 0.3302 | 0.3846 | |
| GSE38129 | IQGAP2 | 10788 | 203474_at | -0.3865 | 0.3019 | |
| GSE45670 | IQGAP2 | 10788 | 203474_at | -1.0994 | 0.0109 | |
| GSE53622 | IQGAP2 | 10788 | 63005 | -0.1990 | 0.0378 | |
| GSE53624 | IQGAP2 | 10788 | 63005 | -0.2206 | 0.0018 | |
| GSE63941 | IQGAP2 | 10788 | 203474_at | 0.6010 | 0.5748 | |
| GSE77861 | IQGAP2 | 10788 | 203474_at | 0.1416 | 0.4993 | |
| GSE97050 | IQGAP2 | 10788 | A_33_P3216372 | -0.0542 | 0.8602 | |
| SRP007169 | IQGAP2 | 10788 | RNAseq | 1.3958 | 0.0284 | |
| SRP008496 | IQGAP2 | 10788 | RNAseq | 0.9748 | 0.0165 | |
| SRP064894 | IQGAP2 | 10788 | RNAseq | 0.0507 | 0.8864 | |
| SRP133303 | IQGAP2 | 10788 | RNAseq | -0.3708 | 0.1444 | |
| SRP159526 | IQGAP2 | 10788 | RNAseq | 0.2947 | 0.4926 | |
| SRP193095 | IQGAP2 | 10788 | RNAseq | -1.1596 | 0.0299 | |
| SRP219564 | IQGAP2 | 10788 | RNAseq | 0.0937 | 0.8702 | |
| TCGA | IQGAP2 | 10788 | RNAseq | -1.1473 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by IQGAP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IQGAP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IQGAP2 | 10788 | 1 | 13 | 16 | |
| GSE20123 | IQGAP2 | 10788 | 1 | 13 | 16 | |
| GSE43470 | IQGAP2 | 10788 | 1 | 13 | 29 | |
| GSE46452 | IQGAP2 | 10788 | 0 | 28 | 31 | |
| GSE47630 | IQGAP2 | 10788 | 1 | 19 | 20 | |
| GSE54993 | IQGAP2 | 10788 | 8 | 1 | 61 | |
| GSE54994 | IQGAP2 | 10788 | 1 | 19 | 33 | |
| GSE60625 | IQGAP2 | 10788 | 0 | 0 | 11 | |
| GSE74703 | IQGAP2 | 10788 | 1 | 9 | 26 | |
| GSE74704 | IQGAP2 | 10788 | 1 | 6 | 13 | |
| TCGA | IQGAP2 | 10788 | 5 | 49 | 42 |
Total number of gains: 20; Total number of losses: 170; Total Number of normals: 298.
Somatic mutations of IQGAP2:
Generating mutation plots.
Highly correlated genes for IQGAP2:
Showing top 20/520 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IQGAP2 | BICC1 | 0.772141 | 5 | 0 | 5 |
| IQGAP2 | IFFO1 | 0.70011 | 5 | 0 | 5 |
| IQGAP2 | IGDCC4 | 0.69119 | 3 | 0 | 3 |
| IQGAP2 | TOR1AIP1 | 0.689843 | 4 | 0 | 4 |
| IQGAP2 | FBN1 | 0.666068 | 7 | 0 | 7 |
| IQGAP2 | ZNF521 | 0.660228 | 3 | 0 | 3 |
| IQGAP2 | ARMC9 | 0.647651 | 3 | 0 | 3 |
| IQGAP2 | DAPK1 | 0.645587 | 6 | 0 | 4 |
| IQGAP2 | VCL | 0.641187 | 4 | 0 | 3 |
| IQGAP2 | SOX17 | 0.637715 | 5 | 0 | 4 |
| IQGAP2 | SYT11 | 0.637579 | 7 | 0 | 6 |
| IQGAP2 | AQP1 | 0.637438 | 4 | 0 | 4 |
| IQGAP2 | CD151 | 0.636768 | 5 | 0 | 4 |
| IQGAP2 | ARHGEF10 | 0.635768 | 6 | 0 | 5 |
| IQGAP2 | OSR1 | 0.635426 | 3 | 0 | 3 |
| IQGAP2 | SAP30 | 0.634496 | 7 | 0 | 6 |
| IQGAP2 | GLT8D2 | 0.633743 | 5 | 0 | 5 |
| IQGAP2 | EGFLAM | 0.633549 | 3 | 0 | 3 |
| IQGAP2 | CCDC92 | 0.631101 | 6 | 0 | 5 |
| IQGAP2 | AKAP12 | 0.629838 | 8 | 0 | 7 |
For details and further investigation, click here
